One of the greatest challenges of 21st century is Antibiotic Resistance(AR). Unless urgent measures are taken it could take epidemic proportions and lead to a situation where even common infections could become fatal due to ineffectiveness of antibiotics and unavailibility of alternative therapies.go through this to have a basic understanding 1antibiotic resistance can spread via food and food chain also , for example sprouts and chicken meat- ar 

Antibiotics save people’s lives...and make bacteria stronger and more likely to kill us.  What is the best practice to balance these conflicting issues? In this problem-based learning module, the students will be evaluating real-life medical situations in conjunction with actual staff at those institutions and offering action plans to be ‘implemented’ there.  In order to accomplish this, the science unit will be interlocking with social studies and a language arts unit that will have them identifying target audiences and sculpting a way to present their findings.  This unit has the potential to be a full problem-based unit as well as highly interdisciplinary--it’s connected to full units in social studies and language arts which stand alone but can be fully integrated if desired.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antimicrobial resistance is a looming threat to global health. As a result, the livestock industry is moving away from using antibiotics in feed to enhance growth. But this shift may have led to increased rates of systemic infections and reduced production efficiency. Alternatives for antibiotic growth promotants (AGPs) are needed, but the mechanism behind the efficiency of AGPs is largely unknown. So, a recent study systematically evaluated the composition and function of the chicken gut microbial community in response to AGPs. The impact of AGPs was dependent on the birds' age and diet as well as the intestinal sampling location. Overall, AGPs had a limited impact on the abundances of specific microbial groups but did shift which groups were influential and exclude others. The chicken gut microbiome functionally responded to AGPs by changing the expression of multiple pathways, including by increasing expression of cell wall formation and antimicrobial resistance mechanism genes..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antibiotic resistance is a growing threat to human and animal health, and this problem is accelerated by the transfer of antibiotic resistance genes (ARGs) between individual bacteria. ARGs tend to accumulate in the gut microbes of animals, and they reflect the resistome, or collection of ARGs, of the environment. Thus, one way to monitor the resistome of an environment could be sampling the gut microbiomes of animals. To that end, researchers examined the gut resistomes of two domesticated honeybee species, _Apis cerana_ and _Apis mellifera_. The resistome corresponded most strongly with the honeybee host species, rather than geographic region. The more heavily managed species, _A. mellifera_, carried the most ARGs and had the heaviest load of transferrable ARGs. However, transferrable ARGs were common in the microbiomes from both honeybee species..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antibiotics are critical treatments for bacterial infections, but antibiotic resistance is a growing problem. Wastewater treatment plants may foster resistance development, since sewage contains both human pathogens and antibiotics or their metabolite. The activated sludge (AS) stage commonly used to treat sewage at these plants is especially microbe-rich and may encourage transfer of antibiotic resistance genes (ARGs) through reproduction (vertical transfer) or movement of mobile genetic elements (horizontal transfer). To learn more, a recent study profiled ARGs and their neighboring genes at five wastewater treatment plants on three continents. Overall, ARG abundance was lower in AS than in incoming sewage (IN). In addition, ARGs tended to colocalize with plasmids and other mobile genetic elements to a greater extent in IN than AS, indicating decreased horizontal transfer potential..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antibiotic resistance is a growing problem worldwide—and in outer space. Spaceflight can promote biofilm formation and antimicrobial resistance development, and astronauts are especially vulnerable to infection due to the unique demands of spaceflight. To support future space travel, it is critical to understand exactly how spaceflight affects microbial diversity and virulence. To learn more, researchers recently used a machine learning algorithm to analyze sequencing data from the Microbial Tracking (MT)-1 mission, which sampled microbes at eight locations on the International Space Station during three flights. The model predicted the presence of hundreds of antibiotic resistance genes (ARGs) in the 226 bacterial strains isolated from the flights, including strains of the potentially very pathogenic bacterium Enterobacter bugandensis and the food poisoning-related bacterium Bacillus cereus..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Resistance to antibiotics is a growing global threat to human and animal health. Much of the current research into antibiotic resistance has focused on the human gut, but significantly less of it has examined rivers, which are akin to a terrestrial ‘gut.’ To close this gap, researchers examined the antibiotic resistance genes and their hosts in the 3rd longest river in the world, the Yangtze. They identified 1853 species of antibiotic-resistant bacteria that collectively carried 31 types of antibiotic resistance genes. Human pathogenic bacteria carried a disproportionately large share of the resistance genes. Specifically, human pathogens accounted for 5.9% of the host population found in the river sediment, but they carried 46% of the resistance genes there. In the water column, human pathogens carried 64% of the resistance genes while representing only 13.4% of the host population. The dominant antibiotic resistance genes differed from those found in the human gut, anthropogenic systems, or lakes..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antimicrobial resistance (AMR) is an increasingly serious threat to global public health. New resistance mechanisms reduce our ability to treat common infectious diseases. Although microorganisms possessing AMR genes are thought to have emerged from natural habitats, better understanding is needed. A new study sought to examine the consequences of introducing antimicrobials into natural environments. Using lichen – a model for well-defined micro-ecosystems consisting of hundreds of microbial species – researchers evaluated changes in microbial communities following exposure to different antimicrobials. They found that the native lichen microbiome comprises highly diverse and low-abundance intrinsic antimicrobial resistance genes (ARGs) to cope with antimicrobial pressure. Antimicrobial-specific shifts occurred in the structure and function of the microbiome following 10 days of exposure to antimicrobials..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In the explorable explanation players can learn how antibiotic resistance happens. They can interact with bacteria in this simulation to learn how when living things reproduce, there is a small amount of variance in their offspring. This allows organisms to respond to changes in their environment over several generations. Applied to bacteria, when they treated with antibiotics, only the strongest survive and multiply, creating an increasing resilient population.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Our microbiomes are in continuous exchange with the microorganisms living in our indoor environments. In hospitals, this interaction may play a critical role in hospital-acquired infections and the rise of antibiotic-resistant bacteria. However, the bacterial colonization dynamics in newly opened hospitals are poorly understood. In a recent study, researchers used a longitudinal metagenomic approach to characterize this process in a newly occupied hospital ward. Sequencing data showed that the taxonomic succession was site-specific and led to stable community structures after only a few weeks. This fast colonization process was characterized by a significant increase in the bacterial biomass and its alpha-diversity. The bacterial composition of the environment could also be linked to exchanges with patient microbiota. They did not detect a rise in pathogenic bacteria during the 30-week study, but the number of antibiotic resistance genes found on the hospital floor increased over time..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.

By the end of this section, you will be able to:Identify bacterial diseases that caused historically important plagues and epidemicsDescribe the link between biofilms and foodborne diseasesExplain how overuse of antibiotic may be creating “super bugs”Explain the importance of MRSA with respect to the problems of antibiotic resistance

By the end of this section, you will be able to:Describe gel electrophoresisExplain molecular and reproductive cloningDescribe uses of biotechnology in medicine and agriculture

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The drug colistin is considered the “last resort” treatment for infections caused by multidrug-resistant Gram-negative bacteria. However, bacterial resistance to colistin is becoming increasingly prevalent, posing a public health threat. To help determine how to address this problem, researchers recently examined a highly colistin- resistant strain of Stenotrophomonas maltophilia. a Gram-negative opportunistic pathogen. The researchers identified a colistin-degrading protease (Cdp) in the strain and confirmed its role in resistance. In coculture experiments with the colistin-susceptible bacterium Pseudomonas aeruginosa, S. maltophilia inactivated colistin via Cdp and thereby protected P. aeruginosa from the antibiotic. This suggests that Cdp-mediated resistance might substantially limit colistin’s efficacy against polymicrobial infections, such as cystic fibrosis, even if some of the microbes present are sensitive to colistin..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antibiotic resistance is increasingly prevalent, with costs to the economy and to human health. Globally, antibiotic usage in livestock is expected to increase by 66% by 2030, and antibiotics used in animals are clinically relevant to humans. Better understanding the effects of different antibiotics and manure management practices will help to decrease the potential for antibiotic resistance. In a recent study, researchers examined the effects of different manure composting techniques in dairy and beef cattle treated with different antibiotic regimens. They found that the total antibiotic resistance gene (ARG) expression, or “resistome,” changed with the progression of composting with time. The relative abundance of ARGs decreased over time in all conditions, except when the compost was externally heated, but in contrast to the overall trend, some ARGs, including Sul1, intI1, beta lactam, and plasmid-associated genes, increased in all finished composts..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antibiotic resistance is a global threat to public health, causing an estimated 700,000 deaths each year. Soil is an important reservoir of antibiotic resistance genes (ARGs), but the potential risk of ARGs in different ecosystems and the effect of land use changes are unknown. In a recent study, researchers investigated ARG types and amounts in three native soil ecosystems: Alaskan tundra, US Midwestern prairie, and Amazon Rainforest. They found high ARG diversity and abundance in all three ecosystems. A total of 10 regulatory and 55 non-regulatory ARGs were identified that were shared by all 26 metagenomes in the three ecosystems. No significant differences were observed in ARG diversity or abundance between native prairie and agricultural soil, while conversion of Amazon rainforest to pasture increased ARG abundance..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Multidrug-resistant bacteria are a threat to both human and animal health worldwide. Bacteria often gain resistance to drugs by collecting antibiotic resistance genes (ARGs) from other bacteria. One potential hotbed for this exchange is wastewater treatment plants (WWTPs), where environmental bacteria co-mingle with human/animal-associated bacteria. Unfortunately, little is known about the epidemiology of multidrug-resistant bacteria in WWTPs. To close this gap, researchers isolated 82 multidrug-resistant bacterial strains from WWTPs and compared their genomes to bacterial genomes found in public databases. Most multidrug-resistant bacteria were not closely related to human/animal-associated bacteria, and those that were closely related had distinct plasmid profiles compared to relatives. Plasmids, as opposed to chromosomes, were also the main carriers of ARGs..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.