Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from the Caenorhabditis Intervention Testing Program in assessing longevity variation across 22 Caenorhabditis strains spanning 3 species, using multiple replicates collected across three independent laboratories. Reproducibility between test sites is high, whereas individual trial reproducibility is relatively low. Of ten pro-longevity chemicals tested, six significantly extend lifespan in at least one strain. Three reported dietary restriction mimetics are mainly effective across C. elegans strains, indicating species and strain-specific responses. In contrast, the amyloid dye ThioflavinT is both potent and robust across the strains. Our results highlight promising pharmacological leads and demonstrate the importance of assessing lifespans of discrete cohorts across repeat studies to capture biological variation in the search for reproducible ageing interventions.

This Wiki has been set up to help assist with learning FANUC's HandlingTool Operations and Programming. While the intention is to help the Erie Community College students of the Mechatronics program, it is freely available to anyone wishing to learn about the use of FANUC robots.

This sequence introduces students to medical microbiology, infectious diseases, and antimicrobial therapy, and focuses on pathogenesis and clinical manifestations of various infectious diseases.

Introducción al español comercial

Word Count: 15161

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This is a simple visual explanation of installing a browser extension on Google Chrome.

Short Description:
This course was created specifically for the study of music, but the contents can be adapted for internships in most curricula.

Word Count: 3464

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This book is designed to guide students on the autism spectrum through a course which develops their interpersonal, academic, and professional skills. It was designed for autistic students at the College of DuPage.

This resource will be updated as needed. For the most recent version, visit: https://cod.pressbooks.pub/interpersonalskillsautism/

The activity asks students to make observations about what occurs when two effervescent antacid tablets are placed into a beaker of water. The Students work together in groups. There are three parts to the activity. In the first part, the tablets are dropped into tap water and student groups (2-4 students) must complete a series of question sheets (one per group) that guide them through thinking about the event. In the second part, a presentation on chemical equilibrium for the carbonate system is given. The starting point is the answers received in the first part. Basic chemical reactions for the carbonate system are presented including equilibrium expressions for each reaction and discussion about open and closed systems. At the end of class, a handout is given to the students. In the third part, three beakers (acidic, neutral and basic solutions, but not indicated) are placed together and two tablets are placed into each beaker. Students are split into two groups (8-12 students) and are asked to describe why the reactions are different. Discussion follows collection of student responses in each part. Once the chemical reactions and equilibrium expressions are presented, they are involved and referenced in all discussions.

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Data Carpentry lesson to learn how to work with Amazon AWS cloud computing and how to transfer data between your local computer and cloud resources. The cloud is a fancy name for the huge network of computers that host your favorite websites, stream movies, and shop online, but you can also harness all of that computing power for running analyses that would take days, weeks or even years on your local computer. In this lesson, you’ll learn about renting cloud services that fit your analytic needs, and how to interact with one of those services (AWS) via the command line.

This textbook introduces readers to the idea of cooperation and mutualism. Cooperatives and mutuals are participatory organizations in which members participate in control and governance, receive economic benefits through patronage refunds or net income, and become owners through equity. These mutual-benefit organizations exist alongside non-profit organizations and investor-benefit organizations through the global economy.

Data Carpentry lesson to understand data structures and common storage and transfer formats for spatial data. The goal of this lesson is to provide an introduction to core geospatial data concepts. It is intended for learners who have no prior experience working with geospatial data, and as a pre-requisite for the R for Raster and Vector Data lesson . This lesson can be taught in approximately 75 minutes and covers the following topics: Introduction to raster and vector data format and attributes Examples of data types commonly stored in raster vs vector format Introduction to categorical vs continuous raster data and multi-layer rasters Introduction to the file types and R packages used in the remainder of this workshop Introduction to coordinate reference systems and the PROJ4 format Overview of commonly used programs and applications for working with geospatial data The Introduction to R for Geospatial Data lesson provides an introduction to the R programming language while the R for Raster and Vector Data lesson provides a more in-depth introduction to visualization (focusing on geospatial data), and working with data structures unique to geospatial data. The R for Raster and Vector Data lesson assumes that learners are already familiar with both geospatial data concepts and the core concepts of the R language.

Pesticide self-poisoning is among the leading cause of suicide worldwide. This presentation provides us with an insight to the risk factors for pesticide self-poisoning, the global burden, prevention and treatment of self-harm with pesticides. The session use Sri Lanka as a case. The presentation is of relevance for researchers as well as for public health practitioners. It exemplifies how the different levels of intervention have to work very closely to make an impact.

This class provides a space for medical students and MD/PhD students, as well as HASTS (History, Anthropology, Science, Technology, and Society) PhD students to discuss social and ethical issues in the biosciences and biotechnologies as they are being developed. Discussions are with course faculty and with leading figures in developing technologies such as George Daley or George Church in stem cell or genomics research, Bruce Walker or Pardis Sabeti in setting up laboratories in Africa, Paul Farmer and Partners in Health colleagues in building local support systems and first world quality care in Haiti, Peru, and Rwanda, and Amy Farber in building patient-centered therapeutic-outcome research for critical but “orphan” diseases. Goals include stimulating students to think about applying their learning in Boston to countries around the world, including using the experiences they have had in their home countries or research experience abroad. Goals also include a mix of patient-doctor care perspectives from medical anthropology, and moving upstream in the research chain to questions of how to move discoveries from basic research through the pipelines into clinical and bedside care.

This course provides an introduction to nuclear science and its engineering applications. It describes basic nuclear models, radioactivity, nuclear reactions, and kinematics; covers the interaction of ionizing radiation with matter, with an emphasis on radiation detection, radiation shielding, and radiation effects on human health; and presents energy systems based on fission and fusion nuclear reactions, as well as industrial and medical applications of nuclear science.

This course provides an introduction to nuclear science and its engineering applications. It describes basic nuclear models, radioactivity, nuclear reactions, and kinematics; covers the interaction of ionizing radiation with matter, with an emphasis on radiation detection, radiation shielding, and radiation effects on human health; and presents energy systems based on fission and fusion nuclear reactions, as well as industrial and medical applications of nuclear science.

Short Description:
We often make judgments about good and bad, right and wrong. Philosophical ethics is the critical examination of these and other concepts central to how we evaluate our own and each others' behavior and choices. This text examines some of the main threads of discussion on these topics that have developed over the last couple of millenia, mostly within the Western cultural tradition. Join the conversation about this and the other books in the Introduction to Philosophy textbook series. Cover art by Heather Salazar; cover design by Jonathan Lashley.

Long Description:
We often make judgments about good and bad, right and wrong. Philosophical ethics is the critical examination of these and other concepts central to how we evaluate our own and each others’ behavior and choices.

This text examines some of the main threads of discussion on these topics that have developed over the last couple of millenia, mostly within the Western cultural tradition. It considers basic questions about moral and ethical judgment: Is there such a thing as something that is really right or really wrong independent of time, place and perspective? What is the relationship between religion and ethics? How can we reconcile self-interest and ethics? Is it ever acceptable to harm one person in order to help others? What do recent discussions in evolutionary biology or have to say about human moral systems? What is the relation between gender and ethics? The authors invite you to participate in their exploration of these and many other questions in philosophical ethics.

If you are adopting or adapting this book for a course, please let us know on our adoption form for the Introduction to Philosophy open textbook series.

Word Count: 46624

ISBN: 978-1-989014-08-0

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Short Description:
We often make judgments about good and bad, right and wrong. Philosophical ethics is the critical examination of these and other concepts central to how we evaluate our own and each others' behavior and choices. This text examines some of the main threads of discussion on these topics that have developed over the last couple of millenia, mostly within the Western cultural tradition. Cover art by Heather Salazar; cover design by Jonathan Lashley. Join the conversation about this and the other books in the Introduction to Philosophy textbook series.

Long Description:
We often make judgments about good and bad, right and wrong. Philosophical ethics is the critical examination of these and other concepts central to how we evaluate our own and each others’ behavior and choices.

This text examines some of the main threads of discussion on these topics that have developed over the last couple of millenia, mostly within the Western cultural tradition. It considers basic questions about moral and ethical judgment: Is there such a thing as something that is really right or really wrong independent of time, place and perspective? What is the relationship between religion and ethics? How can we reconcile self-interest and ethics? Is it ever acceptable to harm one person in order to help others? What do recent discussions in evolutionary biology or have to say about human moral systems? What is the relation between gender and ethics? The authors invite you to participate in their exploration of these and many other questions in philosophical ethics.

If you are adopting or adapting this book for a course, please let us know on our adoption form for the Introduction to Philosophy open textbook series.

Word Count: 46922

ISBN: 978-1-989014-08-0

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

This course serves as an introduction to the current research questions in phonological theory. Topics include metrical and prosodic structure, features and their phonetic basis in speech, acquisition and parsing, phonological domains, morphology, and language change and reconstruction. Activities include problem solving, squibs, and data collection.