The MIT Case Studies in Social and Ethical Responsibilities of Computing (SERC) aims to advance new efforts within and beyond MIT’s Stephen A. Schwarzman College of Computing. The specially commissioned and peer-reviewed cases are brief and intended to be effective for undergraduate instruction across a range of classes and fields of study. The series editors expect the cases will also be of interest for computing professionals, policy specialists, and general readers. All cases will be made freely available via open-access publishing, with author retained copyright, through Creative Commons licensing.
The Series Editors interpret “social and ethical responsibilities of computing” broadly. Some cases focus closely on particular technologies, others on trends across technological platforms. Still others examine social, historical, philosophical, legal, and cultural facets that are essential for thinking critically about present-day efforts in computing and data sciences.

Word Count: 15192

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Short Description:
This book goes over a wide range of cataloging schemata, tools, and norms. It presents a concise but thorough view of the basics of library cataloging practice.

Word Count: 24530

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Summary: Cavitation is the transition of a fluid into vapour due to local reduction of pressure which is generated by high local flow velocities. The transition of a fluid into vapour also occurs during cooking of water by an increase of the local temperature. The term cavitation is generally reserved for conditions in which the temperature of the bulk fluid is not changed. Although cavitation can occur in many situations this course focuses on ship hydrodynamics and ship propellers. The course is divided into five main groups: physics, types and effects of cavitation as well as calculations and test facilities and techniques. Some of these topics are illustrated with the use of videos. (Study goals:) 1. Reproduce the main lines in a selection of the latest developments in the field of propulsion and resistance hydrodynamics, where the current selection of propulsion and resistance topics includes unsteady hydrodynamics of the flow over a foil, cavitation forms, problems and tools for analysis and design, propulsion systems in a service environment and ship drag reduction by air lubrication. 2. Analyse a hydrodynamic problem in the propulsion and resistance area, into well defined sub problems that can be analysed with state of the art knowledge and tools 3. Select the appropriate theory or tool (either numerical or experimental) for an analysis of the identified problem. 4. Reproduce and present to an audience, the main lines in a contemporary publication from the field of Propulsion and Resistance hydrodynamics. 5. Understand, interpret and react to questions from the audience and the lecturer and in doing so, stimulate the scientific debate.

Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students (2021) is an undergraduate medical-level resource for foundational knowledge across the disciplines of genetics, cell biology and biochemistry. This USMLE-aligned text is designed for a first-year undergraduate medical course that is delivered typically before students start to explore systems physiology and pathophysiology. The text is meant to provide the essential information from these content areas in a concise format that would allow learner preparation to engage in an active classroom. Clinical correlates and additional application of content is intended to be provided in the classroom experience. The text assumes that the students will have completed medical school prerequisites (including the MCAT) in which they will have been introduced to the most fundamental concepts of biology and chemistry that are essential to understand the content presented here. This resource should be assistive to the learner later in medical school and for exam preparation given the material is presented in a succinct manner, with a focus on high-yield concepts.

The 276-page text was created specifically for use by pre-clinical students at Virginia Tech Carilion School of Medicine and was based on faculty experience and peer review to guide development and hone important topics.

Available Formats
978-1-949373-42-4 (PDF)
978-1-949373-43-1 (ePub) [coming soon]
978-1-949373-41-7 (Pressbooks) https://pressbooks.lib.vt.edu/cellbio
Also available via LibreTexts: https://med.libretexts.org/@go/page/37584

How to Adopt this Book
Instructors reviewing, adopting, or adapting parts or the whole of the text are requested to register their interest at: https://bit.ly/interest-preclinical.

Instructors and subject matter experts interested in and sharing their original course materials relevant to pre-clinical education are requested to join the instructor portal at https://www.oercommons.org/groups/pre-clinical-resources/10133.

Features of this Book
1. Detailed learning objectives are provided at the beginning of each subsection
2. High resolution, color contrasting figures illustrate concepts, relationships, and processes throughout
3. Summary tables display detailed information
4. End of chapter lists provide additional sources of information
5. Accessibility features including structured heads and alternative-text provide access for readers accessing the work via a screen-reader

Table of Contents
1. Biochemistry basics
2. Basic laboratory measurements
3. Fed and fasted state
4. Fuel for now
5. Fuel for later
6. Lipoprotein metabolism and cholesterol synthesis
7. Pentose phosphate pathway (PPP), purine and pyrimidine metabolism
8. Amino acid metabolism and heritable disorders of degradation
9. Disorders of monosaccharide metabolism and other metabolic conditions
10. Genes, genomes, and DNA
11. Transcription and translation
12. Gene regulation and the cell cycle
13. Human genetics
14. Linkage studies, pedigrees, and population genetics
15. Cellular signaling
16. Plasma membrane
17. Cytoplasmic membranes
18. Cytoskeleton
19. Extracellular matrix

Suggested Citation
LeClair, Renée J., (2021). Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students, Blacksburg, VA: Virginia Tech Publishing. https://doi.org/10.21061/cellbio. Licensed with CC BY NC-SA 4.0.

About the Author
Renée J. LeClair is an Associate Professor in the Department of Basic Science Education at the Virginia Tech Carilion School of Medicine, where her role is to engage activities that support the departmental mission of developing an integrated medical experience using evidence-based delivery grounded in the science of learning. She received a Ph.D. at Rice University and completed a postdoctoral fellowship at the Maine Medical Center Research Institute in vascular biology. She became involved in medical education, curricular renovation, and implementation of innovative teaching methods during her first faculty appointment, at the University of New England, College of Osteopathic Medicine. In 2013, she moved to a new medical school, University of South Carolina, School of Medicine, Greenville. The opportunities afforded by joining a new program and serving as the Chair of the Curriculum committee provided a blank slate for creative curricular development and close involvement with the accreditation process. During her tenure she developed and directed a team-taught student-centered undergraduate medical course that integrated the scientific and clinical sciences to assess all six-core competencies of medical education.

Accessibility Note
The University Libraries at Virginia Tech and Virginia Tech Publishing are committed to making its publications accessible in accordance with the Americans with Disabilities Act of 1990. The HTML (Pressbooks) and ePub versions of this book utilize header structures and include alternative text which allow for machine-readability.

Please report any errors at https://bit.ly/feedback-preclinical

Short Description:
Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students, is an undergraduate medical-level resource for foundational knowledge across the disciplines of genetics, cell biology and biochemistry. This text is designed for a course in first year undergraduate medical course that is delivered typically before students start to explore systems physiology and pathophysiology. The text is meant to provide the essential information from these content areas in a concise format that would allow learner preparation to engage in an active classroom. Clinical correlates and additional application of content is intended to be provided in the classroom experience. The text assumes that the students will have completed medical school prerequisites (including the MCAT) in which they will have been introduced to the most fundamental concepts of biology and chemistry that are essential to understand the content presented here. This resource should be assistive to the learner later in medical school and for exam preparation given the material is presented in a succinct manner, with a focus on high-yield concepts.NewParaAdditional versions of this book are freely available at: https://doi.org/10.21061/cellbio and https://med.libretexts.org/@go/page/37584.NewParaInstructors reviewing, adopting, or adapting parts or the whole of the text are requested to register their interest at: https://bit.ly/interest-preclinical. Instructors and subject matter experts interested in sharing original supplemental materials are invited to join https://www.oercommons.org/groups/pre-clinical-resources/10133.

Word Count: 63120

ISBN: 978-1-957213-05-7

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine.

In this unit, students look at the components of cells and their functions and discover the controversy behind stem cell research. The first lesson focuses on the difference between prokaryotic and eukaryotic cells. In the second lesson, students learn about the basics of cellular respiration. They also learn about the application of cellular respiration to engineering and bioremediation. The third lesson continues students' education on cells in the human body and how (and why) engineers are involved in the research of stem cell behavior.

Short Description:
This book describes the simplified architecture of an IoT network from the core functional perspective and then presents step-by-step procedures to establish a connection between the IoT device and platform. It practically shows how to connect a cellular IoT module to the Microsoft Azure IoT Hub using the LTE-M technology.

Word Count: 11073

ISBN: 978-1-990132-03-2

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

In this course we will explore how altered metabolism drives cancer progression. Students will learn (1) how to read, discuss, and critically evaluate scientific findings in the primary research literature, (2) how scientists experimentally approach fundamental issues in biology and medicine, (3) how recent findings have challenged the traditional “textbook” understanding of metabolism and given us new insight into cancer, and (4) how a local pharmaceutical company is developing therapeutics to target cancer metabolism in an effort to revolutionize cancer therapy.

This quick tour provides a brief introduction to the Cellular Microscopy Phenotype Ontology (CMPO). It covers the scientific principles that led to the creation of this ontology and how it can be used.

By the end of the course you will be able to:
Describe the role of CMPO
Search and browse the ontology and use it to annotate data

This course includes:

Surveying the molecular and cellular mechanisms of neuronal communication.
Coversion channels in excitable membrane, synaptic transmission, and synaptic plasticity.
Correlation of the properties of ion channels and synaptic transmission with their physiological function such as learning and memory.
Discussion of the organizational principles for the formation of functional neural networks at synaptic and cellular levels.

This course reviews the processing and structure of cellular materials as they are created from polymers, metals, ceramics, glasses, and composites, develops models for the mechanical behavior of cellular solids, and shows how the unique properties of honeycombs and foams are exploited in applications such as lightweight structural panels, energy absorption devices and thermal insulation. The applications of cellular solids in medicine include increased fracture risk due to trabecular bone loss in patients with osteoporosis, the development of metal foam coatings for orthopaedic implants, and designing porous scaffolds for tissue engineering that mimic the extracellular matrix. Modelling of cellular materials applied to natural materials and biomimicking is explored. Students taking the graduate version of the class are required to complete additional assignments.

Life as an emergent property of networks of chemical reactions involving proteins and nucleic acids. Mathematical theories of metabolism, gene regulation, signal transduction, chemotaxis, excitability, motility, mitosis, development, and immunity. Applications to directed molecular evolution, DNA computing, and metabolic and genetic engineering.

This course covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation, including molecular structure and assembly of MHC molecules, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. The course is structured as a series of lectures and tutorials in which clinical cases are discussed with faculty tutors.
Lecturers
Frederick W. Alt, Marcus Altfeld, Paul Anderson, Jon C. Aster, Hugh Auchincloss, Steven P. Balk, Samuel M. Behar, Richard S. Blumberg, Francisco Bonilla, Bobby Cherayil, Benjamin Davis, David Hafler, Nir Harcohen, Bruce Horwitz, David M. Lee, Andrew Lichtman, Diane Mathis, Richard Mitchell, Hidde Ploegh, Emmett Schmidt, Arlene Sharpe, Megan Sykes, Shannon Turley, Dale T. Umetsu, Ulrich von Andrian, Bruce Walker, Kai Wucherpfennig, Ramnik Xavier, Sarah Henrickson

Students first discover what they want from their education, then build a plan to get there. This content takes students through the steps to successfully navigate their journey in higher education. Topics include planning for success, choosing a career path, setting and attaining goals, understanding financial management, developing critical thinking skills, making healthy choices, using effective communication, managing time, developing learning strategies, developing meaningful relationships. Content is available in PDF and Open Document formats and is licensed CC BY. Learning Objectives also are provided. Full course offering available at https://www.cengage.com/c/opennow-college-success-1e-opennow-cengage

Students first discover what they want from their education, then build a plan to get there. This content takes students through the steps to successfully navigate their journey in higher education. Topics include planning for success, choosing a career path, setting and attaining goals, understanding financial management, developing critical thinking skills, making healthy choices, using effective communication, managing time, developing learning strategies, developing meaningful relationships. Content is available in PDF and Open Document formats and is licensed CC BY. Learning Objectives also are provided. Full course offering available at https://www.cengage.com/c/opennow-college-success-1e-opennow-cengage

Students first discover what they want from their education, then build a plan to get there. This content takes students through the steps to successfully navigate their journey in higher education. Topics include planning for success, choosing a career path, setting and attaining goals, understanding financial management, developing critical thinking skills, making healthy choices, using effective communication, managing time, developing learning strategies, developing meaningful relationships. Content is available in PDF and Open Document formats and is licensed CC BY. Learning Objectives also are provided.

This activity engages learners in exploring the impact of climate change on arctic sea ice in the Bering Sea. They graph and analyze sea ice extent data, conduct a lab on thermal expansion of water, and then observe how a scientist collects long-term data on a bird population.

This quick tour provides a brief introduction to ChEBI, the EBI's Chemical Entities of Biological Interest database, which focuses on 'small' chemical compounds.

By the end of the course you will be able to:
explain what the ChEBI Database is and how you can use it to access chemical compounds of interest
demonstrate where to find out more about ChEBI