This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Bariatric surgeries like gastric bypass are often used for weight loss, but they can also help protect patients from fatal heart attacks, possibly by altering the levels of gut-derived metabolic hormones like GLP-1, leptin, ghrelin, and insulin, which are known to affect heart tissue, or by acting on heart tissue directly. Researchers recently investigated the mechanisms by performing three common bariatric surgeries on non-obese, non-diabetic rats. Ten weeks later, the researchers subjected the rats to simulated heart attacks by restricting and reestablishing their cardiac blood flow. Both Roux-en-Y gastric bypass and sleeve gastrectomy, but not ileal transposition surgery, reduced the size of the damaged area in the heart and the no-reflow area to which blood flow couldn’t be restored. Gastric bypass and sleeve gastrectomy also increased GLP-1 and leptin levels, while sleeve gastrectomy reduced ghrelin levels. In contrast, none of the surgeries affected insulin levels..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"New research suggests that a low-calorie diet might help reverse symptoms of type 2 diabetes in men with obesity. The findings of the study add to a growing body of evidence indicating that diabetes is a reversible condition. Authors of the study looked at 18 men in South Africa who were over the age of 35, had class III obesity, and were on insulin treatment for diabetes. The participants were randomized to one of two groups: one followed a commercially available low-fat, low-calorie diet consisting of vegetables and a vegetable-soup-based meal plan; while the control group received a calorie-restricted meal plan. All participants were encouraged to engage in physical activity according to their abilities and to visit a counseling psychologist at least once a month. Over the course of 6 months, the team tracked the men’s levels of blood glucose and glycated hemoglobin, or HbA1c—using those measures to establish diabetes status..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"New findings from the ACTIONI-O study suggest that when it comes to tackling weight loss, people with obesity and healthcare professionals don’t always see eye to eye. Reported misconceptions about the factors contributing to obesity and about patient attitudes suggest much room for improving communication and education. In what’s considered the largest study of its type, researchers surveyed more than 14500 people with obesity and more than 2700 healthcare professionals treating patients with obesity in 11 countries. Surveys designed foreach group asked about perceived attitudes, behaviors, and barriers to effective obesity care. For example, patients were asked whether they consider their weight loss completely their responsibility. While clinicians were asked, among other things, to rank criteria they consider in determining whether to spark a discussion with a patient about obesity, such as patient weight, BMI, or mental state..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Many people exercise and take medicine in order to delay or treat type 2 diabetes. However in most cases these interventions in one’s lifestyle fails and the person regain weight and retain their increasing blood glucose levels. Controlling one’s appetite seems to be the key, which is one of the aspects we’ll discuss in this presentation. Furthermore we’ll discuss how gastric bypass surgery helps people with diabetes type 2 controlling their appetite and make their diabetes disappear. Finally we’ll discuss how hormones such as GLP-1 can help diabetics’ control their appetite, and lose weight.

Narrator: Richard Steed.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Losing weight through lifestyle interventions alone can be challenging. Unfortunately, the options for effective drug treatment are limited. And those that are available require frequent, daily dosing. Now, a new treatment option tested among patients with diabetes could be a solution for those with obesity but not diabetes. Shown to significantly reduce body weight vs. placebo, efpeglenatide is one of the latest of an entire class of diabetes-targeted drugs observed to have beneficial effects beyond glycemic control. Efpeglenatide is a long-lasting glucagon-like peptide-1 receptor agonist, or GLP-1 RA. The drug is currently being developed to improve glycemic control in patients with type 2 diabetes as a once-weekly subcutaneous administration. But like other GLP-1 RAs, efpeglenatide also helps patients lose weight..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"When weight loss attempts fail, people sometimes turn to surgery. Roux-en-Y gastric bypass is a last-resort treatment that alters gut architecture to cause substantial and sustained weight loss. The surgery alters the intestinal microbiota in the patient, which affects nutrient absorption. Unfortunately, it can be difficult to separate the effects from the surgery from those of the weight loss it causes. In a recent study, researchers used a rat model of gastric bypass to measure the changes in the resident gut microbes. They compared rats after surgery to weight-matched partners that didn’t receive surgery. 16S rRNA gene sequencing and metaproteomics revealed that the overall diversity of microbes decreased following surgery. Interestingly, changes varied by location, and the proportion of certain bacteria increased while others decreased. Metabolism-related changes were also seen in the gut microbes, including changes in amino acid and bile acid metabolism..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Healthy lifestyle conversations are challenging for healthcare professionals General practitioners are short on time, and nurses don’t want to offend patients New research has identified four strategies that promote healthy living conversations (1) Select the right environment – a private area is ideal for a one-on-one conversation (2) Focus on patient needs, not desired outcomes (3) Talk about healthy practices during routine visits (4) Build a rapport with patients to encourage broader health discussions These strategies make it easier for any healthcare professional to deliver healthy lifestyle interventions But more information is needed on patient perspectives about lifestyle conversations Keyworth et al. (2019). Healthcare professionals' barriers and enablers to providing opportunistic behaviour change interventions during routine medical consultations..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Despite the availability of effective and safe glucose-lowering agents, many patients with type 2 diabetes do not achieve glycemic targets. This finding suggests that when it comes to deciding on treatment options, efficacy and safety are only part of the equation; patients’ preferences, needs, and values should also guide decision-making. In this vein, researchers explored the attitudes of patients with inadequately controlled type 2 diabetes towards semaglutide. Semaglutide is an injectable, once-weekly glucagon-like peptide-1 receptor agonist, or GLP-1 RA. Growing research has shown semaglutide to be safe and effective for controlling glucose levels and to induce weight loss in people with type 2 diabetes..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"One promising way to fight obesity and its complications is to keep fat tissue in the body from expanding But as simple as that sounds, researchers aren’t yet sure where to start While the antioxidant-regulating protein Nrf2 is known to play a role in the development of fat tissue activating or de-activating Nrf2 appears to have the same fat-reducing effect Now, researchers could have a better handle on Nrf2’s role Through genetic and protein analyses, one team has discovered that Nrf2 works in concert with the receptor PDGFRα PDGFRα is critical for the development of certain organs and tissues, including body fat The team found that, in the absence of the adaptor protein Nck1, PDGFRα activation and Nrf2 expression are increased Activating the PDGFRα-Nrf2 pathway in mice impaired bone marrow cells’ ability to turn into fat These findings mirror those obtained by the same team for cells gathered from white fat tissue in mice Though it’s not yet clear how the results will carry o.."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This slide presentation is designed to help students to identify red flags of fad dieting as well as ways to maintain a healthy weight. The worksheet is designed to assess students on the objectives. The information in the presentation is primarily derived from kidshealth.org. Please make a copy of the slides and the worksheet document, then feel free to use as is or remix for your classroom. 

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new clinical trial has shown promising results for those trying to shed excess pounds: researchers have zeroed in on a combination of herbal extracts that can significantly increase weight loss under the right circumstances. The news could mean better health for the more than 1 billion people who are overweight or obese worldwide. Traditional pharmaceutical and surgical options for weight management are expensive and often associated with adverse effects. The herbal formulation – composed of extracts from three common culinary spices used in Indian cooking – was developed as a high-quality natural alternative. The combination tackles excess body weight through a multi-layered approach, by both preventing fat cells from maturing and boosting existing fat break down. To determine the safety and efficacy of the extracts, researchers performed a randomized, double-blind, placebo-controlled clinical trial with healthy overweight adults..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.