This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"It’s a feared moment for every scientist: the discovery that years of painstaking research has led to results that can't be repeated. Many think that poorly characterized antibodies have contributed to this reproducibility crisis more than any other laboratory tool. A new study published in Molecular Cell supports this hypothesis, at least in the context of chromatin immunoprecipitation. Although accurate ChIP interpretation depends on near-perfect antibody specificity, the report shows that many of these reagents are far less capable than their advertising suggests, which calls into question several widely accepted paradigms on genomic regulation. The study focused on histone post-translational modifications; specifically all three methylation states of lysine 4 on histone H3. Through ChIP experiments, H3K4 methylation has been strongly linked to transcriptional control..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Consuming high amounts of red meat is commonly linked to an increased risk of developing cancer, especially colorectal cancer. At the same time, antibodies against Neu5Gc , a carbohydrate derived from red meat, have been observed to worsen cancer in “human-like” mice. While these antibodies and red meat consumption are each believed to increase cancer risk, it remains unknown how diet affects the antibodies. Now, research suggests that consuming Neu5Gc from red meat and dairy can modulate the amounts and properties of anti-Neu5Gc antibodies in humans, providing clues to how the carbohydrate might be linked to cancer. The team behind the study calculated daily intake of Neu5Gc for more than 19,000 subjects aged 18 years or older. These participants provided regular logs of food consumed over 24-hour periods as part of the NutriNet-Santé study, which was designed to investigate relationships between nutrition and health status..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

These materials provide resources for those wanting to assist students with their reading comprehension and vocabulary. See section 1, titled "Overview" for additional information. The Overview (section 1) also contains a common course cartridge with the assessments for these learning materials including quizzes, discussions, and writing assignments. 

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Molecular signaling pathways are crucial for cellular function and communication. In order to work properly, the pathways must be sensitive, adaptable, and tunable to specific stimuli and situations. These essential qualities are made possible by intrinsically disordered proteins (IDPs). IDPs can’t fold into stable, defined structures on their own, but many IDPs can gain at least some structure when they bind with specific partners. These and other interactions change the IDPs’ conformations to enable specific and reversible binding, giving the signaling pathways the sensitivity and flexibility they need to function correctly. Algorithms and other computational tools can help identify IDPs and predict their functions. So far, such tools have revealed that IDPs are pervasive in all kingdoms of life. In addition, they’ve shown that IDPs help relay signals from diverse stimuli, such as ions, lipids, proteins, chemicals, and environmental cues in every category of cell signaling pathway and at every step..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Researchers from Sun-Bio Medical Device Company have designed a new drug that delivers a one-two punch to lung cancer cells. Shown to be potent against human tumor cells grafted onto nude mice, the drug is a promising candidate for treating lung cancer in humans. Despite advances in cancer diagnosis and treatment, lung cancer remains the deadliest form of the disease. Surgery and chemotherapy are two go-to methods for treatment. Unfortunately, neither is 100% effective. That has many researchers turning to more precise, molecular-level targeting strategies—most notably by using antibodies. Researchers can design antibodies to lock onto and disrupt receptors that keep cancer cells alive and replicating. And not just one type at a time. So-called bispecific antibodies seek out two targets at once and have proven therapeutically more effective than their single-target counterparts..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"With the COVID-19 pandemic causing a global health crisis, accurate diagnosis is critical. Diagnosing acute disease relies on RT-PCR tests measuring the presence of SARS-CoV-2 in the sampled material but in patients with suspected COVID-19 with a negative RT-PCR result, measuring anti-viral antibodies can help clinicians identify infected individuals. Antibody testing can also determine if someone was previously infected and help to measure the prevalence of the virus in a community. A new study characterizes an assay measuring total antibodies – combined IgA, IgM, and IgG isotypes – against SARS-CoV-2. The assay, ECLIA, specifically measures antibodies against the S1 subunit of the viral spike, which carries the virus’s receptor binding domain. Researchers in Liechtenstein evaluated ECLIA in a population with 125 cases of confirmed SARS-CoV-2 infection and 1159 individuals without evidence of COVID-19. The results showed a test sensitivity of 97.6%, while the specificity was 99.8%..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.