A mini series of choose your own adventure cases for students to explore blood bank workflow and decision making. Topics covered:Hemolytic Disease of the NewbornABO DiscrepancyCrossmatchingAuto Antibodies
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"With the COVID-19 pandemic causing a global health crisis, accurate diagnosis is critical. Diagnosing acute disease relies on RT-PCR tests measuring the presence of SARS-CoV-2 in the sampled material but in patients with suspected COVID-19 with a negative RT-PCR result, measuring anti-viral antibodies can help clinicians identify infected individuals. Antibody testing can also determine if someone was previously infected and help to measure the prevalence of the virus in a community. A new study characterizes an assay measuring total antibodies – combined IgA, IgM, and IgG isotypes – against SARS-CoV-2. The assay, ECLIA, specifically measures antibodies against the S1 subunit of the viral spike, which carries the virus’s receptor binding domain. Researchers in Liechtenstein evaluated ECLIA in a population with 125 cases of confirmed SARS-CoV-2 infection and 1159 individuals without evidence of COVID-19. The results showed a test sensitivity of 97.6%, while the specificity was 99.8%..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.