The lethal poison Ricin (best known as a weapon of bioterrorism), Diphtheria toxin (the causative agent of a highly contagious bacterial disease), and the widely used antibiotic tetracycline have one thing in common: They specifically target the cell’s translational apparatus and disrupt protein synthesis.
In this course, we will explore the mechanisms of action of toxins and antibiotics, their roles in everyday medicine, and the emergence and spread of drug resistance. We will also discuss the identification of new drug targets and how we can manipulate the protein synthesis machinery to provide powerful tools for protein engineering and potential new treatments for patients with devastating diseases, such as cystic fibrosis and muscular dystrophy.
This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.

By the end of this section, you will be able to:Describe the structure of nucleic acids and define the two types of nucleic acidsExplain the structure and role of DNAExplain the structure and roles of RNA

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Most current knowledge about gut microbiomes has been obtained from studies on mammals, while the microbiomes of fish, the most diverse group of vertebrates (~33,000 species), are less well understood. Specifically, the major influencing factors and unique features of fish gut microbiomes remain unclear. To bridge this knowledge gap, a recent study analyzed the gut contents of 227 fish representing 85 different freshwater fish (FWF) and saltwater fish (SWF) species. rRNA sequencing revealed that Proteobacteria and Firmicutes were the two most abundant phyla, indicating a different composition from the typical vertebrate microbiome, which is composed mainly of Firmicutes and Bacteroidetes. Habitat (freshwater versus saltwater) more strongly influenced the host microbiome than host taxonomy or trophic level and the microbiome taxonomic and functional profiles were better indicators of a fish’s habitat than of its taxonomy..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.