In this presentation, we will discuss how bacterial pathogen adapt to the …
In this presentation, we will discuss how bacterial pathogen adapt to the human host environment during long-term chronic infections. In continuation of this, we will discuss how the opportunistic pathogen - Pseudomonas aeruginosa - evolves during adaptation to the airways of cystic fibrosis patients.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"The drug colistin is considered the “last resort” treatment for infections caused by multidrug-resistant Gram-negative bacteria. However, bacterial resistance to colistin is becoming increasingly prevalent, posing a public health threat. To help determine how to address this problem, researchers recently examined a highly colistin- resistant strain of Stenotrophomonas maltophilia. a Gram-negative opportunistic pathogen. The researchers identified a colistin-degrading protease (Cdp) in the strain and confirmed its role in resistance. In coculture experiments with the colistin-susceptible bacterium Pseudomonas aeruginosa, S. maltophilia inactivated colistin via Cdp and thereby protected P. aeruginosa from the antibiotic. This suggests that Cdp-mediated resistance might substantially limit colistin’s efficacy against polymicrobial infections, such as cystic fibrosis, even if some of the microbes present are sensitive to colistin..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
No restrictions on your remixing, redistributing, or making derivative works. Give credit to the author, as required.
Your remixing, redistributing, or making derivatives works comes with some restrictions, including how it is shared.
Your redistributing comes with some restrictions. Do not remix or make derivative works.
Most restrictive license type. Prohibits most uses, sharing, and any changes.
Copyrighted materials, available under Fair Use and the TEACH Act for US-based educators, or other custom arrangements. Go to the resource provider to see their individual restrictions.
