This course focuses on computational and experimental analysis of biological systems across …
This course focuses on computational and experimental analysis of biological systems across a hierarchy of scales, including genetic, molecular, cellular, and cell population levels. The two central themes of the course are modeling of complex dynamic systems and protein design and engineering. Topics include gene sequence analysis, molecular modeling, metabolic and gene regulation networks, signal transduction pathways and cell populations in tissues. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.
The eleventh episode of "The Other Fifty Weeks: An Open Education Podcast", …
The eleventh episode of "The Other Fifty Weeks: An Open Education Podcast", discussing the recognition of prior learning and open education with Marc Singer.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"The tyrosine kinase p56 Lck is critical for T-cell development and activation. Lck initiates signaling events downstream of the T-cell receptor (TCR) by phosphorylating ITAM motifs located within CD3 chains, which in turn recruits the kinase Zap-70 to the activated TCR/CD3 complex. But while the regulation of its enzymatic activity is mostly attributed to two tyrosine residues, Y394 and Y505, Lck has an additional highly conserved tyrosine, Y192, whose function in the regulation of Lck activity is not fully understood. A recent study examined the role of this residue in primary T cells and T cell lines. Using knock-in mice expressing a phosphomimetic mutant of Lck (LckY192E), researchers found that Lck Y192E bound poorly to CD45 and showed hyperphosphorylation at Y505, similar to previous data in Jurkat cell lines. However, in vitro, Lck Y192E had normal enzymatic activity in both human and mouse T cells, suggesting that this residue acts independently of the interaction with CD45..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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