This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Autophagy is an important cellular recycling process that degrades misfolded proteins and damaged organelles. In typical (“canonical”) autophagy, membranes derived from the endoplasmic reticulum surround damaged materials that need to be degraded, and the proteins Atg5 and Atg7 help form specialized digestion compartments (autophagosomes), but another type of autophagy, called alternative autophagy, was recently discovered. In alternative autophagy, the membranes that envelop the damaged materials are derived from the trans-Golgi membrane, and Atg5 and Atg7 do not participate in autophagosome formation. Alternative autophagy seems to be activated primarily under conditions of cell stress, and it plays roles in many diseases, such as heart disease, neurodegenerative disease, cancer, inflammatory bowel disease, and bacterial infection..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In small groups, students experiment and observe the similarities and differences between human-made objects and objects from nature. They compare the function and structure of hollow bones with drinking straws, bird beaks, tool pliers, bat wings and airplane wings. Observations are recorded in a compare & contrast chart, and then shared in a classroom discussion, along with follow up assessment activities such as journal writing and Venn diagrams.

The subject of this course is the historical process by which the meaning of “technology” has been constructed. Although the word itself is traceable to the ancient Greek root teckhne (meaning art), it did not enter the English language until the 17th century, and did not acquire its current meaning until after World War I. The aim of the course, then, is to explore various sectors of industrializing 19th and 20th century Western society and culture with a view to explaining and assessing the emergence of technology as a pivotal word (and concept) in contemporary (especially Anglo-American) thought and expression.
Note: In the interests of freshness and topicality we regard the STS.464 syllabus as sufficiently flexible to permit some — mostly minor — variations from year to year. One example of a different STS.464 syllabus can be found in STS.464 Technology and the Literary Imagination, Spring 2008.

This is an advanced course on modeling, design, integration and best practices for use of machine elements such as bearings, springs, gears, cams and mechanisms. Modeling and analysis of these elements is based upon extensive application of physics, mathematics and core mechanical engineering principles (solid mechanics, fluid mechanics, manufacturing, estimation, computer simulation, etc.). These principles are reinforced via (1) hands-on laboratory experiences wherein students conduct experiments and disassemble machines and (2) a substantial design project wherein students model, design, fabricate and characterize a mechanical system that is relevant to a real world application. Students master the materials via problems sets that are directly related to, and coordinated with, the deliverables of their project. Student assessment is based upon mastery of the course materials and the student’s ability to synthesize, model and fabricate a mechanical device subject to engineering constraints (e.g. cost and time/schedule).

This is a continuation of Freshman Organic Chemistry I (CHEM 125a), the introductory course on current theories of structure and mechanism in organic chemistry for students with excellent preparation in chemistry and physics. This semester treats simple and complex reaction mechanisms, spectroscopy, organic synthesis, and some molecules of nature.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Colon cancer is the third most common and the second deadliest cancer worldwide. There are several known risk factors, which include gallbladder removal, or cholecystectomy, but the causal link between the two has not yet been confirmed. The gallbladder regulates bile acid metabolism, and its removal may lead to an overload of secondary bile acids. Researchers recently found that gallbladder removal in a colitis-associated mouse model promoted colon cancer development. Further, gallbladder removal elevated plasma levels of the secondary bile acid deoxycholic acid (DCA). In cultured colon cancer cells, DCA administration promoted cellular proliferation and migration and altered the expression of over 200 genes. Some of the upregulated genes were correlated with the important signaling pathway Wnt and cell cycle-associated pathways. DCA treatment also reduced expression of the receptor FXR, which subsequently increased levels of β-Catenin and c-Myc in both cultured cells and mice..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Pyroptosis is a self-destruction sequence initiated by cells when infected by pathogens such as bacteria. This programmed cell death helps clear the body of infection, but the molecular mechanism controlling that process has remained a mystery. Now, new research points to the molecules mTORC1 and STAT3 as important participants in pyroptosis in human immune cells. Researchers examined how pyroptosis is initiated in macrophages by S. aureus, the bacteria that cause “staph” infections. Experiments showed that using rapamycin to inhibit mTORC1, a protein that regulates conventional forms of cell death, led to pyroptosis in macrophages. causing the cells to swell with characteristically large bubbles. Further experiments revealed that mTORC1 works in conjunction with STAT3, another cell death protein. Blocking STAT3, using the inhibitor Stattic, also led to pyroptosis. The findings indicate that the mTORC1/STAT3 axis is critical to pyroptosis in human macrophages..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Postpartum systemic oxidative stress is common in dairy cows and can lead to health complications and production loss. While the gut microbiota can influence host health and stress, its role in dairy cow postpartum oxidative stress was unclear until a recent study found a strong link between the fecal microbiota and postpartum oxidative stress in dairy cows. Compared to low oxidative stress (LOS) cows, those with high oxidative stress (HOS) had altered bacterial community composition, including 16 species from 9 genera that were negatively correlated with oxidative stress. There were also changes in the microbiota’s functional behavior and related metabolites, and the findings suggested that changes in glutathione synthesis played a causative role in oxidative stress. Specifically, HOS cows had reduced microbial metabolism of amino acids involved in glutathione synthesis..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"In cancer, tumor cells secrete chemicals that suppress immune function by upregulating the expression of immune “brakes”. Immunotherapy with checkpoint inhibitors can release these brakes to effectively treat certain types of cancer. However, other types of cancer are resistant to checkpoint inhibitors, so alternate treatments are needed. In mouse models, infection with the malaria parasite Plasmodium can activate immune defense against cancer. Similarly, global human epidemiological data indicate that malaria occurrence is inversely associated with cancer mortality. In mice, Plasmodium induces proinflammatory molecule production, immune cell activation, and subsequent systemic immune responses while simultaneously upregulating the expression of brake molecules through a feedback mechanism of the immune system to prevent unchecked damage by these immune responses..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This intermediate organic chemistry course focuses on the methods used to identify the structure of organic molecules, advanced principles of organic stereochemistry, organic reaction mechanisms, and methods used for the synthesis of organic compounds. Additional special topics include illustrating the role of organic chemistry in biology, medicine, and industry.

This intermediate organic chemistry course focuses on the methods used to identify the structure of organic molecules, advanced principles of organic stereochemistry, organic reaction mechanisms, and methods used for the synthesis of organic compounds. Additional special topics include illustrating the role of organic chemistry in biology, medicine, and industry.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Esophageal cancers are common globally but are difficult to treat and have a poor prognosis. Esophageal squamous cell carcinoma (ESCC) is especially dangerous and has poorly understood molecular mechanisms. A recent study took a comprehensive look at the kappa opioid receptor (KOR), a protein that has been shown to influence the progression of other cancers. First, researchers examined existing patient datasets and found that ESCC tumors had reduced KOR expression and that lower expression of KOR was correlated with reduced patient survival. In the lab, they found that reducing KOR expression in cultured ESCC cells led to increased proliferation, invasion, and metastasis. When looking for potential mechanisms, they found that down-regulation of KOR activated the PDK1-AKT signaling pathway. It also led to invasion-related changes in cells, including invadopodia formation and cytoskeletal rearrangement. Reducing expression of KOR in mice led to increased metastasis and phosphorylation of the AKT enzyme..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In this activity, learners build a simple mechanism that regulates the "escape" of energy released by a falling weight by portioning it into discrete amounts. Escapements are found in mechanical clocks, such as those driven by a pendulum or a spring. Learners will build the wrapping form of escapement said to be used in a fifteenth-century German clock.

Our linked subjects are (1) the historical process by which the meaning of technology has been constructed, and (2) the concurrent transformation of the environment. To explain the emergence of technology as a pivotal word (and concept) in contemporary public discourse, we will examine responses — chiefly political and literary — to the development of the mechanic arts, and to the linked social, cultural, and ecological transformation of 19th- and 20th-century American society, culture, and landscape.
Note: In the interests of freshness and topicality we regard the STS.464 syllabus as sufficiently flexible to permit some — mostly minor — variations from year to year. One example of a different STS.464 syllabus can be found in STS.464 Cultural History of Technology, Spring 2005.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Accumulating evidence suggests that psilocybin – the primary psychedelic compound found in so-called magic mushrooms – can be used to safely treat a range of psychiatric conditions. Prior studies have shown that just one or two doses of psilocybin can have a rapid and lasting positive impact on mental health, but the associated brain mechanisms aren’t well understood. Now, researchers based in the United Kingdom have used functional magnetic resonance imaging to map the brain activity of nineteen patients with treatment-resistant major depression who were given psilocybin. The results shed light on how the compound changes human brain function. The patients were dosed with the drug as part of an open-label clinical trial. Before and one day after treatment, the researchers used fMRI to look at cerebral blood flow and brain functional connectivity – a measure of how different regions of the brain interact..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.