This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Alirocumab, a drug that inhibits PCSK9 and helps clear the blood of atherogenic lipids, may be of benefit for individuals with type 2 diabetes who are most at risk of cardiovascular disease. According to the International Diabetes Federation, heart disease is the leading cause of death among people with type 2 diabetes. One factor that might contribute to that grim statistic is the high mixed dyslipidemia prevalence in this population. Mixed dyslipidemia is characterized by elevated triglycerides, and hence high triglyceride-rich lipoprotein, or remnant cholesterol, and high cholesterol levels; and low serum levels of high-density lipoprotein cholesterol, or HDL-C. Despite treatment with statins and other lipid-lowering therapies targeting atherogenic lipoproteins, management of mixed dyslipidemia remains challenging, especially among individuals with diabetes..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This course examines the growing importance of medicine in culture, economics and politics. It uses an historical approach to examine the changing patterns of disease, the causes of morbidity and mortality, the evolution of medical theory and practice, the development of hospitals and the medical profession, the rise of the biomedical research industry, and the ethics of health care in America.

Building on concepts taught in the associated lesson, students learn about bioelectricity, electrical circuits and biology as they use deductive and analytical thinking skills in connection with an engineering education. Students interact with a rudimentary electrocardiograph circuit (made by the teacher) and examine the simplicity of the device. They get to see their own cardiac signals and test the device themselves. During the second part of the activity, a series of worksheets, students examine different EKG print-outs and look for irregularities, as is done for heart disease detection.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Coronary heart disease is a serious condition, and its prognosis is largely determined by the degree of myocardial ischemia/reperfusion (MI/R) injury. MI/R injury occurs when blood returns to cardiac tissues and is partly a function of calcium overload and endoplasmic reticulum (ER) stress. There is growing evidence that estrogen is protective against MI/R injury and a recent study examined the potential mechanisms of this protective effect in rats and cultured cells. Reducing estrogen levels by removing both ovaries exacerbated MI/R injury and reduced levels of SERCA2a, a critical calcium ion pump, but SERCA2a could be increased to nearly normal levels by estrogen supplementation (17β-estradiol). Both supplemental estrogen and exogenous SERCA2a overexpression decreased signs of ER stress and alleviated myocardial damage. Conversely, reducing SERCA2a expression exacerbated ER stress and myocardial damage, and adding estrogen after that reduction could not protect against the damage or ER stress..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Congenital heart defects affect approximately 1% of all babies born each year and account for almost 20% of all newborn deaths. Early diagnosis while still in the womb can greatly improve an affected baby’s chance of survival. Unfortunately, diagnosis relies exclusively on ultrasound imaging, where accurate readings aren’t guaranteed. Researchers in Japan are tackling this problem by enlisting the help of artificial intelligence. More importantly, they’re helping the doctors entrusted with patient care to understand how AI programs spot heart defects. Advancements in artificial intelligence have improved how congenital heart defects are diagnosed. Ultrasound videos of fetal hearts beating normally and others with structural defects can be studied with AI, which can then determine whether the fetal hearts in new videos are abnormal or not..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Psychology is designed to meet scope and sequence requirements for the single-semester introduction to psychology course. The book offers a comprehensive treatment of core concepts, grounded in both classic studies and current and emerging research. The text also includes coverage of the DSM-5 in examinations of psychological disorders. Psychology incorporates discussions that reflect the diversity within the discipline, as well as the diversity of cultures and communities across the globe.Senior Contributing AuthorsRose M. Spielman, Formerly of Quinnipiac UniversityContributing AuthorsKathryn Dumper, Bainbridge State CollegeWilliam Jenkins, Mercer UniversityArlene Lacombe, Saint Joseph's UniversityMarilyn Lovett, Livingstone CollegeMarion Perlmutter, University of Michigan

By the end of this section, you will be able to:Explain the nature of psychophysiological disordersDescribe the immune system and how stress impacts its functioningDescribe how stress and emotional factors can lead to the development and exacerbation of cardiovascular disorders, asthma, and tension headaches

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A healthy heart is one that stays in shape—literally. Remodeling of the heart’s structure is both a cause and an effect of heart disease. One molecule that could help fortify the heart against harmful reshaping is STING. STING is a signaling molecule that triggers a fleet of protective chemicals during infection, but recent studies suggest STING could also play a role in heart injury. To explore this role, researchers monitored STING in mouse models of heart remodeling. Mice experiencing heart remodeling showed elevated levels of STING. To isolate the effects of STING, certain mice were genetically altered to overexpress the molecule. Compared with unmodified mice, these high-STING mice showed smaller changes in heart size and better overall heart function. Cell experiments revealed that STING could provide these protective effects by combating autophagy. Autophagy is the process of degrading and recycling parts of the cell and is the driver of heart remodeling..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In this lesson the students will learn how the heart functions. Students will be introduced to the concept of action potential generation. The lesson will explain how action potential generation causes the electrical current that causes muscle contraction in the heart. Students will be introduced to the basic electrical signal generated by the heart; P, QRS, and T waves. The lesson will approach the heart from an engineering standpoint and encourage students to design ways to improve heart function. Students will also learn the basic steps of the engineering design process.

Episode 1, part 1: Interview with Sir Michael Marmot, Professor of Epidemiology and Public Health at University College London about the current state of Global Health, with special focus on Health Equity. The first episode consists of two parts.
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The Swedish Global Health Podcast - A Podcast about Global Health and Sustainable Development is aimed at anyone interested in knowing more about this exciting topic! It is co-produced by the Swedish Society of Medicine's Committee for Global Health and the Swedish Society of Medicine's student and junior doctor section.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Cell death is a hallmark of various abnormalities of the heart, including heart failure, heart attack, and ischemia. While the long-term effects of cell death in the heart have been described, the cellular processes that occur immediately after cell death remain poorly understood. Now, by tracking the movement of calcium ions, researchers are gaining a better idea of what happens right after individual heart cells die. Calcium ions regulate vital cell functions in mammals and therefore serve as a valuable signal of cellular activity and intercell connections. When zapping and killing a single heart muscle cell with a laser, researchers found that different types of surrounding cells responded differently. Nearby myocytes showed a slow and sustained uptick in calcium “sparks,” while distant myocytes were weakly or not affected. This activity was accompanied by mechanical damage in myocytes. Fibroblasts, however, showed rapid shock waves of calcium ion activity..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Asia has 365 million elderly people, and this population is expected to reach 520 million by 2030 Asian countries also had the highest rates of dementia in the 2015 World Alzheimer Report Because the risks of dementia and hypertension - which are related - increase with age, Asia is facing a troubling trend in its aging population The HOPE Asia Network conducted a much-needed review of hypertension and dementia in Asia They found that Asians had low awareness of hypertension as a major risk factor for brain damage and compared to developed countries, Asian countries had poorer hypertension management The HOPE Network emphasized the importance of controlling blood pressure variability to preserve cognitive functions by reducing vascular dementia risk and global stroke burden and suggested that Asia must focus on detecting hypertension and lowering blood pressure in midlife to protect against later-life cognitive decline in its growing elderly population Turana et al..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.