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Biology
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CC BY
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Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.

Subject:
Biology
Life Science
Material Type:
Full Course
Provider:
Rice University
Provider Set:
OpenStax College
Date Added:
08/22/2012
Biology, Animal Structure and Function, Animal Reproduction and Development, Human Pregnancy and Birth
Conditional Remix & Share Permitted
CC BY-NC
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By the end of this section, you will be able to:Explain fetal development during the three trimesters of gestationDescribe labor and deliveryCompare the efficacy and duration of various types of contraceptionDiscuss causes of infertility and the therapeutic options available

Subject:
Applied Science
Biology
Life Science
Material Type:
Module
Date Added:
07/10/2017
GDF-8 promotes placenta formation by upregulating MMP2 via Snail
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"During pregnancy, the placenta acts as a critical bridge between mother and child, providing oxygen and nutrients to the developing baby. One important process in placenta formation is “invasion” of the mother’s blood supply by placental cells called extravillous trophoblasts (EVTs). This process is promoted by the enzyme MMP2, whose expression is upregulated by the protein GDF-8, but the exact mechanism is unclear. To learn more, researchers recently examined GDF-8, MMP2, and cell invasion in human EVTs in vitro. They found that treatment with GDF-8 indeed stimulated MMP2 expression in the cells. This effect was blocked by an inhibitor of TGF-β type I receptors, indicating that the TGF-β pathway was involved. Further investigation revealed that the TGF-β signaling proteins Snail and Slug were also upregulated by GDF-8. However, silencing Snail and Slug expression individually showed that only Snail was required for GDF-8-mediated MMP2 stimulation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/08/2023