This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Insulin resistance in neurons is linked to neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease. The regulation of neuronal insulin signaling by phosphatases isn’t fully understood. To learn more, researchers recently investigated the role of the protein phosphatase PP1 in neuronal insulin signaling and resistance. They found that the PP1 isoform PP1γ, but not PP1α, participated in insulin signaling in mouse and human neuroblastoma cell lines. PP1γ dephosphorylated AKT2, thereby limiting AS160 phosphorylation, GLUT4 translocation, and glucose uptake. It also regulated GSK3β phosphorylation through AKT2, while it regulated GSK3α phosphorylation through IKK and MLK3. Through its effects on these two GSK3 isoforms, PP1γ fine-tuned the development of Aβ plaques and neurofibrillary tangles these are hallmarks of Alzheimer’s disease. Specifically, PP1γ increased neurofibrillary tangle formation but suppressed amyloid β plaque formation in neuronal cells..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 05/01/2023
