This training course is an introduction to the use of the AFNI …
This training course is an introduction to the use of the AFNI software suites for the analysis of functional MRI (fMRI) data. It is not intended as an introduction to how fMRI works but is aimed at people who are already doing fMRI data analysis, or those who will be in the near future. AFNI (Analysis of Functional NeuroImages) is a leading software suite of C, Python, and R programs and shell scripts, primarily developed for the analysis and display of anatomical and fMRI data. It is freely available for research purposes. This event was organized by the Center for Brains, Minds, and Machines (CBMM) Trainee Leadership Council. CBMM is a multi-institutional NSF Science and Technology Center headquartered at MIT that is dedicated to developing a computationally based understanding of human intelligence and establishing an engineering practice based on that understanding. CBMM brings together computer scientists, cognitive scientists, and neuroscientists to create a new field—the science and engineering of intelligence.
Many clinical trials conducted by academic organizations are not published, or are …
Many clinical trials conducted by academic organizations are not published, or are not published completely. Following the US Food and Drug Administration Amendments Act of 2007, “The Final Rule” (compliance date April 18, 2017) and a National Institutes of Health policy clarified and expanded trial registration and results reporting requirements. We sought to identify policies, procedures, and resources to support trial registration and reporting at academic organizations. Methods We conducted an online survey from November 21, 2016 to March 1, 2017, before organizations were expected to comply with The Final Rule. We included active Protocol Registration and Results System (PRS) accounts classified by ClinicalTrials.gov as a “University/Organization” in the USA. PRS administrators manage information on ClinicalTrials.gov. We invited one PRS administrator to complete the survey for each organization account, which was the unit of analysis. Results Eligible organization accounts (N = 783) included 47,701 records (e.g., studies) in August 2016. Participating organizations (366/783; 47%) included 40,351/47,701 (85%) records. Compared with other organizations, Clinical and Translational Science Award (CTSA) holders, cancer centers, and large organizations were more likely to participate. A minority of accounts have a registration (156/366; 43%) or results reporting policy (129/366; 35%). Of those with policies, 15/156 (11%) and 49/156 (35%) reported that trials must be registered before institutional review board approval is granted or before beginning enrollment, respectively. Few organizations use computer software to monitor compliance (68/366; 19%). One organization had penalized an investigator for non-compliance. Among the 287/366 (78%) accounts reporting that they allocate staff to fulfill ClinicalTrials.gov registration and reporting requirements, the median number of full-time equivalent staff is 0.08 (interquartile range = 0.02–0.25). Because of non-response and social desirability, this could be a “best case” scenario. Conclusions Before the compliance date for The Final Rule, some academic organizations had policies and resources that facilitate clinical trial registration and reporting. Most organizations appear to be unprepared to meet the new requirements. Organizations could enact the following: adopt policies that require trial registration and reporting, allocate resources (e.g., staff, software) to support registration and reporting, and ensure there are consequences for investigators who do not follow standards for clinical research.
Intern Prescot Nelson at Succinct Psychology (Psychcinct), under the guidance of professor …
Intern Prescot Nelson at Succinct Psychology (Psychcinct), under the guidance of professor Daniel Reynolds, created the entire course series for the Psych2e Openstax textbook. We are allowing everyone to share and embed this resource.
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