This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Losing weight through lifestyle interventions alone can be challenging. Unfortunately, the options for effective drug treatment are limited. And those that are available require frequent, daily dosing. Now, a new treatment option tested among patients with diabetes could be a solution for those with obesity but not diabetes. Shown to significantly reduce body weight vs. placebo, efpeglenatide is one of the latest of an entire class of diabetes-targeted drugs observed to have beneficial effects beyond glycemic control. Efpeglenatide is a long-lasting glucagon-like peptide-1 receptor agonist, or GLP-1 RA. The drug is currently being developed to improve glycemic control in patients with type 2 diabetes as a once-weekly subcutaneous administration. But like other GLP-1 RAs, efpeglenatide also helps patients lose weight..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Statins are the first-line treatment for hypercholesterolemia in patients at high risk for cardiovascular mortality. But some patients require additional LDL cholesterol lowering to reach risk-stratified LDL-cholesterol levels or to further reduce cardiovascular risk. Clinical trials have demonstrated that the PCSK9 inhibitor evolocumab effectively lowers LDL cholesterol and is well tolerated. A new analysis of data from a subset of these trials extends these findings by evaluating LDL cholesterol lowering in patients receiving different evolocumab dosage regimens. Researchers performed a pooled analysis of data from four randomized 12-week phase 3 clinical trials comparing evolocumab to placebo or ezetimibe. Two subcutaneous evolocumab dosage regimens were examined: 140 mg every two weeks, and 420 mg monthly. Patients received evolocumab either as monotherapy or with background lipidlowering therapies, consisting of a statin alone or with ezetimibe..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The gut microbiome – comprising the microbes that reside inside our digestive systems – produces many metabolites that affect human physiology. The composition and diversity of gut microbes has been associated with diseases as diverse as GI disorders, diabetes, cardiovascular disease, depression, and rheumatoid arthritis. To better understand the relationship between diet and gut microbiota, a recent study used a cross-sectional approach. By examining fecal microbiota from the Cooperative Health Research in the Region of Augsburg study, including 1,992 participants, researchers applied latent Dirichlet allocation (LDA) to identify 20 microbial subgroups within the population. They found that 8 of 20 subgroups were associated with dietary habits, while 9 of 20 were associated with the prevalence of metabolic diseases and risk factors..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Diseases like epilepsy and diabetes are linked to inflammation and oxidative stress which can be further complicated by persistent high blood glucose levels Drug-based treatments can help, but issues of tolerance, effectiveness, and compliance can complicate treatment The ketogenic diet (KD) reduces blood glucose and insulin, helping individuals to manage their condition But adherence to a strict KD can be difficult A recent study at the University of South Florida identified a promising possible alternative to KD adherence Using rodent models of epilepsy and glucose intolerance as well as non-disease models Researchers evaluated blood glucose levels after administration of exogenous ketone supplements Animals given exogenous ketones had lower blood glucose levels, both when resting and after exercise This treatment was effective for all of the disease models evaluated, and it also helped reduce blood glucose in rodents without pathology at different age ranges Further preclinical and clin.."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

A five-page illustrated handout for Medical Office and Laboratory Assistants that explains:
- What a Glucose Tolerance Test (GTT) is
- Why monitoring diabetes is important
- What equipment is necessary for a proper GTT
- How to prepare the patient for a GTT
- How to conduct the GTT
- When blood and urine should be collected
- What could interfere with the test results
- Possible complications from the test
- When to alert the doctor and nurse
- What the test results mean
- How to report the test results

Learning about medical vocabulary Lesson OverviewIn this lesson, students will learn about basic medical vocabulary. The focus of this lesson is to discover the previous knowledge of the students about medical vocabulary and help them expanding it thought the activities proposed. Lesson PreparationRead the lesson and explore the resource libraryAs the class is develop, pay attention and try to find students who need support. These students can be assigned a partner.Give the students more sources to acquire medical vocabulary.                    

This sequence explores the elements of innate and acquired immune defense mecahnisms, the cells involved, their development and maturation, and biomolecular cellular communication mechanisms required to successfully fight off infection.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Despite the availability of effective and safe glucose-lowering agents, many patients with type 2 diabetes do not achieve glycemic targets. This finding suggests that when it comes to deciding on treatment options, efficacy and safety are only part of the equation; patients’ preferences, needs, and values should also guide decision-making. In this vein, researchers explored the attitudes of patients with inadequately controlled type 2 diabetes towards semaglutide. Semaglutide is an injectable, once-weekly glucagon-like peptide-1 receptor agonist, or GLP-1 RA. Growing research has shown semaglutide to be safe and effective for controlling glucose levels and to induce weight loss in people with type 2 diabetes..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new report in Diabetes, Obesity and Metabolism suggests that insulin glargine 300 U/mL provides glycaemic control equivalent to that of insulin glargine 100 U/mL with less hypoglycaemia across a wide range of HbA1c levels in people with type 2 diabetes. Hypoglycaemia is a key factor limiting optimal glycaemic control in diabetes. In treating diabetes, glargine 300 has more stable and prolonged pharmacokinetic and pharmacodynamic profiles than glargine 100. Previous analysis of data from the EDITION 1, 2 and 3 clinical trials showed that this translated into less hypoglycaemia and comparable glycaemic control with glargine 300 relative to glargine 100. However, the analysis was unable to assess whether this reduced risk was limited to individuals with a particular HbA1c level, or whether it was achieved irrespective of the degree of glycaemic control attained..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Diabetes and chronic kidney disease are common comorbid conditions, with reports suggesting that chronic kidney disease affects up to half of all patients with type 2 diabetes. Renal impairment complicates the management of diabetes because it increases the risk of heart disease and excessively low blood glucose levels called hypoglycemia. These risks limit the options for glucose-lowering treatment. Insulin remains a viable treatment option for people with diabetes and chronic kidney disease. However, there is limited data from large studies that compare how different insulins impact treatment outcomes in this patient population. A recent patient-level meta-analysis of the phase III EDITION trials helps bridge this data gap by investigating the impact of renal function on the safety and efficacy of insulin glargine 100 versus the newer insulin glargine 300..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

The purpose of this lesson is to expand the student´s knowledge about diabetes.
The world experience an epidemic of type 2 diabetes, especially in low and middle-income countries. Diabetes is no longer a disease of high-income countries and urban cities but impact upon rural populations and the poorest segments of the population.
Participants: Professor Venkat Narayan.

In recent decades, it has been recognized that maternal health and fetal development plays a critical role in developing diabetes and at the same time, diabetes is an important but often unrecognized contributor to maternal morbidity and mortality. This presentation talks about the links between diabetes and maternal, and child health. Furthermore, it is explored why an intergenerational perspective on diabetes prevention is needed.

A patient discusses diabetes and how he manages his carbohydrate intake in this video segment from TV 411.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"In diabetic nephropathy (DN), a common complication of diabetes, the structure and function of the kidneys deteriorate. One early sign of DN is proteinuria, or protein excretion in urine. Although the mechanism of DN-related proteinuria isn’t clear, rearrangement of the cellular skeleton, or cytoskeleton, might contribute. A recent study explored this theory by examining the role of the cytoskeletal protein MAP4 in DN proteinuria. In urine from patients with diabetes as well as kidney tissues from diabetic mice, the content of phosphate-modified (phosphorylated) MAP4 was elevated. In mice, inducing MAP4 phosphorylation promoted the development of DN-like proteinuria with aging and caused podocytes, specialized kidney cells that prevent proteins from entering urine, to lose their epithelial characteristics and die. In addition, mice with induced MAP4 phosphorylation were much more susceptible to diabetes than normal mice..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This course presents a challenging multi-dimensional perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, and infectious diseases. Students create analytical models to derive estimates for historically variant population risk factors and physiological rate parameters, and conduct analyses of familial data to separately estimate inherited and environmental risks. The course evaluates the basic population genetics of dominant, recessive and non-deleterious inherited risk factors.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"For people with diabetes, the dangers of high blood sugar are long established. Now, scientists have uncovered additional components in the blood that can worsen the disease. In a new article in the Journal of Physiology, researchers report that microparticles shed from cells under diabetic conditions have unique inflammatory properties that may help explain the multiple organ vascular dysfunction that’s common to the disease. Microparticles have been increasingly recognized as important biomarkers in various health conditions. But most prior reports have relied on in vitro studies to evaluate particle function. Because in vitro experiments can’t fully replicate physiological conditions, defining exactly how microparticles affect disease progression has been tricky. This prompted researchers to look at the link between microparticles and diabetes-induced vascular dysfunction in vivo, in the microvessels of streptozotocin-induced diabetic rats..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

 The course seeks to familiarize the learners with the possibilities involved in the management of diabetes and hypertension. This course is to make medical knowledge simpler and accessible for common people. This will help reduce anxiety about the diseases. Reduction in the incidence of threatening complications like cerebral stroke, heart attack, kidney failure, blindness,  diabetic foot and amputations is the goal we need to achieve. The health-aware person, a learner of this course, can be a patient itself, a relative, a neighbor, or anyone from society. Some basic education and a will to help the patient is all that is required. 

 The course seeks to familiarize the learners with the possibilities involved in the management of diabetes and hypertension. This course is to make medical knowledge simpler and accessible for common people. This will help reduce anxiety about the diseases. Reduction in the incidence of threatening complications like cerebral stroke, heart attack, kidney failure, blindness,  diabetic foot and amputations is the goal we need to achieve. The health-aware person, a learner of this course, can be a patient itself, a relative, a neighbor, or anyone from society. Some basic education and a will to help the patient is all that is required. 

 The course seeks to familiarize the learners with the possibilities involved in the management of diabetes and hypertension. This course is to make medical knowledge simpler and accessible for common people. This will help reduce anxiety about the diseases. Reduction in the incidence of threatening complications like cerebral stroke, heart attack, kidney failure, blindness,  diabetic foot and amputations is the goal we need to achieve. The health-aware person, a learner of this course, can be a patient itself, a relative, a neighbor, or anyone from society. Some basic education and a will to help the patient is all that is required. 

 The course seeks to familiarize the learners with the possibilities involved in the management of diabetes and hypertension. This course is to make medical knowledge simpler and accessible for common people. This will help reduce anxiety about the diseases. Reduction in the incidence of threatening complications like cerebral stroke, heart attack, kidney failure, blindness,  diabetic foot and amputations is the goal we need to achieve. The health-aware person, a learner of this course, can be a patient itself, a relative, a neighbor, or anyone from society. Some basic education and a will to help the patient is all that is required.