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Viral infection of hematopoietic stem cells
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Hematopoietic stem cells (HSCs) are critical for maintaining healthy blood and immune cell populations. They’re also valuable resources and targets for medical treatments, such as HSC transplantation and gene therapy. However, these blood cell precursors are susceptible to viral infection, which can cause blood disorders and limit the efficacy of HSC-based therapies. In fact, viral infection is a leading cause of complications and death among HSC transplant recipients. For example, latent cytomegalovirus can become reactivated after transplantation leading to immunosuppression, pneumonia, encephalitis, and graft failure. HSC transplantation also reduces the numbers of T cells that are specifically cytotoxic toward the mononucleosis- inducing Epstein–Barr virus. Furthermore, recipients of HSC transplants are more susceptible to infection by SARS-CoV-2, the cause of the COVID-19 pandemic..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/15/2023
Virus capture facilitates a sensitive viral diagnosis for pathogens including SARS-CoV-2
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"When new viruses emerge, early detection is critical, but the detection of pathogens in clinical and environmental samples using high-throughput sequencing is often hampered by large amounts of background material. Enormous sequencing depth can be necessary to gain sufficient information to identify a certain pathogen. Now, a study demonstrates a new method to improve the sensitivity of viral diagnosis. Combining high-throughput sequencing with in-solution virus capture, researchers compiled a virus genome dataset for the design of a RNA-baits panel. The panel, called VirBaits, consists of about 178,000 RNA-baits based on over 18,000 complete viral genomes, targeting 35 epizootic and zoonotic viruses, including SARS-CoV-2. In a test of complex samples, viruses with both DNA and RNA genomes were enriched by anywhere from 10-fold to 10,000-fold, with enriched viruses having at least 72% overall identity shared with the viruses in the bait set..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
02/26/2021
Voices from the Heart of Gotham: Guttman Community College
Conditional Remix & Share Permitted
CC BY-NC-SA
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As producers of knowledge with a particular focus on social (in)justice, racial, gendered and transnational journeys, Guttman Community College scholar-activists have constructed a new digital canon that offers New Yorkers the opportunity to contribute testimonies of tumultuous times. Curated by Dr. Samuel Finesurrey, Guttman undergraduates Elsy Rosario, Tigida Fadiga, Luz Hidalgo, Phisarys Sidemion, and Sadaf Majeed and digitized by Guttman staff members Joanna Wisniewski, Ivan Mora, and Kristina Jiana Quiles, this collection democratizes the production of knowledge by empowering community college students, largely deriving from immigrant households, to shape the narratives told about their communities and their generation. Organized into five themes, with testimonies gathered in six languages, this archive documents a diverse set of New York experiences. Funded by the American Council of Learned Societies and the Mellon Foundation, this exhibition helps us rethink struggles and movements of the past and present, to unearth the human networks that carry all New Yorkers in difficult times.

Subject:
History
Material Type:
Data Set
Primary Source
Author:
Samuel Finesurrey
Date Added:
01/10/2022
Wearing shoes indoors might be linked to COVID-19 mortality rate
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new preprint reports one factor that might contribute to the deadliness of the COVID-19 pandemic: wearing shoes indoors. Researchers compared COVID-19 death rates between countries that follow the cultural practice of removing shoes indoors and those that do not and observed a distinct pattern. Those where removing shoes is customary showed a lower death rate on average. Interestingly, no significant differences were observed when countries were compared according to the number of COVID-19 cases. It could be that the lack of reliable, universal testing may obscure the true prevalence of the disease. More work is still needed to discount a number of confounding factors, such as differences in preventive measures enacted by different countries, but the correlation suggests that removing shoes indoors might help curb the devastation wrought by the COVID-19 pandemic..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
06/23/2020
Wellness and Care in Writing Center Work
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CC BY-NC-ND
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For writing center and writing program scholars, administrators, and practitioners hungry for changing how we labor and how we teach writing, this book details several interventions, pedagogies, and programmatic approaches that place wellness, vulnerability, and anti-racist community care at the forefront of our work. For practitioners outside of the United States, I hope that this book generates meaningful conversations about wellness challenges and care opportunities and leads to interventions that are culturally-specific and site-specific. Of course, as I have detailed in my other work on wellness and labor, the pandemic has given new urgency to these conversations and has upped their stakes. This book, then, is an artifact of a pre-pandemic world. While subsequent revisions have woven in pandemic-specific reflections and information, we are still sorting through the wreckage of a harrowing year. In years to come, I hope that we will look back on this period of uncertainty and fear, and process how the pandemic reshaped us: our work, our tutoring and teaching practices, our attitudes about our institutions, our profession, our programmatic goals. I also hope we examine what the pandemic failed to reshape and the many aspects of the academy that the pandemic adversely shaped.

Subject:
Education
Higher Education
Material Type:
Textbook
Provider:
Shippensburg University Open Press
Author:
Benjamin Villarreal
Christina Lundberg
Claire Helakoski
Elise Dixon
Genie Nicole Giaimo
Kacy Walz
Kristi Murray Costello
Lauren Brentnell
Miranda Mattingly
Rachel Robinson
Sarah Brown
Yanar Hashlamon
Date Added:
04/15/2021
<p>Herd immunity is not a realistic exit strategy during a COVID-19 outbreak</p>
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The world is combating an ongoing COVID-19 pandemic1-4. Health-care systems, society and the economy are impacted in an unprecedented way. It is unclear how many people have contracted the causative coronavirus (SARS-CoV-2) unknowingly. Therefore, reported COVID-19 cases do not reflect the true scale of outbreak5-9. Natural herd immunity has been suggested as a potential exit strategy during COVID-19 outbreaks, which may arise when 50-67% of a community has been infected10. Here we present the prevalence and distribution of antibodies to SARS-CoV-2 in a healthy adult population of a highly affected country using a novel immunoassay, indicating that one month into the outbreak (i) the seroprevalence in the Netherlands is 2.7% with substantial regional variation, (ii) the hardest-hit areas show a seroprevalence of up to 9..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
06/20/2023