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DEBATE-statistical analysis plans for observational studies
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Background All clinical research benefits from transparency and validity. Transparency and validity of studies may increase by prospective registration of protocols and by publication of statistical analysis plans (SAPs) before data have been accessed to discern data-driven analyses from pre-planned analyses. Main message Like clinical trials, recommendations for SAPs for observational studies increase the transparency and validity of findings. We appraised the applicability of recently developed guidelines for the content of SAPs for clinical trials to SAPs for observational studies. Of the 32 items recommended for a SAP for a clinical trial, 30 items (94%) were identically applicable to a SAP for our observational study. Power estimations and adjustments for multiplicity are equally important in observational studies and clinical trials as both types of studies usually address multiple hypotheses. Only two clinical trial items (6%) regarding issues of randomisation and definition of adherence to the intervention did not seem applicable to observational studies. We suggest to include one new item specifically applicable to observational studies to be addressed in a SAP, describing how adjustment for possible confounders will be handled in the analyses. Conclusion With only few amendments, the guidelines for SAP of a clinical trial can be applied to a SAP for an observational study. We suggest SAPs should be equally required for observational studies and clinical trials to increase their transparency and validity.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Reading
Provider:
BMC Medical Research Methodology
Author:
Bart Hiemstra
Christian Gluud
Frederik Keus
Iwan C. C. van der Horst
Jørn Wetterslev
Date Added:
08/07/2020
DECOMPOSITION OF STARCH LAB
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Chemical reactions play an important role in our digestive system. This activity will allow you to observe one of those reactions, known as a decomposition reaction.  Decomposition is a reaction that breaks down a complex substance into simpler substances. You will be using the enzyme amylase to break down a starch into a simple sugar. This lab will simulate what is happening in your mouth when your saliva (which contains the enzyme amylase) begins to break down the complex carbohydrate starch.

Subject:
Health, Medicine and Nursing
Material Type:
Activity/Lab
Author:
Teresa Walters
Date Added:
06/18/2023
DIFFUSION OF WATER WITH GUMMY BEARS
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To investigate the movement of water into and out of a polymer.  Gummy Bears are made of gelatin and sugar.  Gelatin is a polymer that forms large three-dimensional matrices which give structural support to jellies and jams, and a lot of other things you use every day. This process will simulate what happens in your body cells.

Subject:
Health, Medicine and Nursing
Material Type:
Activity/Lab
Author:
Teresa Walters
Date Added:
06/18/2023
DISEÑO DE FÁRMACOS (2016)
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CC BY-NC-ND
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Hay muchas formas diferentes de administrar medicamentos al organismo para una finalidad específica y determinada. Hasta la fecha se han identificado unas 500 estructuras moleculares que actúan como objetivos de los fármacos.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lecture
Provider:
Lindau Nobel Laureate Meetings
Provider Set:
Mini Lectures
Date Added:
04/13/2018
D-Lab: Medical Technologies for the Developing World
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D-Lab Health provides a multidisciplinary approach to global health technology design via guest lectures and a major project based on fieldwork. We will explore the current state of global health challenges and learn how to design medical technologies that address those problems. Students may travel to Nicaragua during spring break to work with health professionals, using medical technology design kits to gain field experience for their device challenge. As a final class deliverable, you will create a product design solution to address challenges observed in the field. The resulting designs are prototyped in the summer for continued evaluation and testing.

Subject:
Applied Science
Economics
Health, Medicine and Nursing
Social Science
Material Type:
Full Course
Provider Set:
MIT OpenCourseWare
Author:
Gomez-Marquez, Jose
Date Added:
02/01/2010
D-Lab: Water, Climate Change, and Health
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CC BY-NC-SA
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D-Lab: Water, Climate Change, and Health is a project-based, experiential, and transdisciplinary course. Together with peers and experts, we will explore the vitally important interface of water, climate change, and health. This course addresses mitigation and adaptation to climate change as it pertains to water and health. Water-borne illness, malnutrition, and vector-borne diseases represent the top three causes of morbidity and mortality in regions of our focus. Students submit a term project, setting the stage for a lifelong commitment to communicating climate science to a broad public.

Subject:
Applied Science
Atmospheric Science
Health, Medicine and Nursing
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Murcott, Susan
Simpson, Juliet
Date Added:
02/01/2019
D-Lab: Water, Sanitation, and Hygiene
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This course focuses on disseminating Water, Sanitation and Hygiene (WASH) or water/environment innovations in developing countries and underserved communities worldwide. It emphasizes core WASH and water/environment principles, culture-specific solutions, tools for start-ups, appropriate and sustainable technologies, behavior change, social marketing, building partnerships, and the theory and practice of innovation diffusion.

Subject:
Applied Science
Atmospheric Science
Economics
Engineering
Environmental Science
Health, Medicine and Nursing
Physical Science
Social Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Hsu, Libby
Murcott, Susan
Date Added:
09/01/2019
DNA and the end replication problem
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This activity will help students understand how the enzyme telomerase works to solve the "end replication problem."

Subject:
Anatomy/Physiology
Applied Science
Health, Medicine and Nursing
Life Science
Material Type:
Diagram/Illustration
Interactive
Module
Provider:
Oregon State University
Author:
Open Oregon State
Oregon State University
Date Added:
05/18/2021
DRAFT ONLY Cognitive Neuroscience
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CC BY-NC
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Short Description:
This textbook supports learning about cognitive neuroscience at a third-year undergrad level. It was collaboratively developed by the 2023 cognitive neuroscience (PSYC 384) students of St. Francis Xavier University (among others), and is continuously edited and updated by Dr. Erin Mazerolle.

Word Count: 23872

Included H5P activities: 5

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Textbook
Date Added:
01/26/2024
DRUG TARGETS (2014)
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Drug research has contributed more to the progress of medicine during the past century than any other scientific factor. With lecture snippets of Gerhard Domagk, Gertrude Elion and Brian Kobilka this Mini Lectures introduces to the fundamental research methods of drug targeting.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lecture
Provider:
Lindau Nobel Laureate Meetings
Provider Set:
Mini Lectures
Date Added:
04/13/2018
DRUG TARGETS (GERMAN) (2014)
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CC BY-NC-ND
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Die Angriffspunkte für Medikamente unterschiedlicher Art gestalten sich vielfältig. Mit Vortragsauszügen der Laureaten Gerhard Domagk, Gertrude Elion und Brian Kobilka führt diese Mini Lecture in die zentralen Methoden und Forschungsschwerpunkte des drug targeting ein.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lecture
Provider:
Lindau Nobel Laureate Meetings
Provider Set:
Mini Lectures
Date Added:
04/13/2018
Danyelle Wolf – "Coolness Fades, Achievements Last"
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CC BY-NC
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Three-time USA Boxing National Champion Danyelle Wolf knows that staying clean, working hard, and setting goals early on in life has helped her become the best. After completing the Danyelle Wolf worksheet, encourage students to share their natural highs by having them hashtag #LiveNaturallyHigh on their social media accounts.

How to use our resources:
1) Watch a dynamic video featuring a powerful, personal story
2) Discuss the video in a group using provided discussion guides
3) Engage in deeper learning through fun, interactive activities that reinforce the concepts from the video.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lesson
Unit of Study
Author:
Natural High
Date Added:
09/03/2024
The Dark Side of Mineral Mining
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Students choose one of four short articles to read about mineral mining, including the impacts of mining on the Native American community in the region. Each article highlights a specific example where the Indigenous community's interests are in conflict with the mining company's interests. After reading one of the articles, students post a short reflection to a discussion board, then respond to at least one classmate's reflection.

(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)

Subject:
Applied Science
Biology
Career and Technical Education
Ecology
Environmental Studies
Geology
Health, Medicine and Nursing
Life Science
Physical Science
Material Type:
Homework/Assignment
Provider:
Science Education Resource Center (SERC) at Carleton College
Provider Set:
Teach the Earth
Author:
Karen Helgers
Date Added:
08/23/2022
Darrin Henson – Saying Yes to Life
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CC BY-NC
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World-renowned choreographer Darrin Henson has worked with Michael Jackson, Prince, Britney Spears and many more. His love of dancing gives him more than drugs ever could. After completing the Darrin Henson worksheet, encourage students to share their natural highs by having them hashtag #LiveNaturallyHigh on their social media accounts.

How to use our resources:
1) Watch a dynamic video featuring a powerful, personal story
2) Discuss the video in a group using provided discussion guides
3) Engage in deeper learning through fun, interactive activities that reinforce the concepts from the video.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lesson
Unit of Study
Author:
Natural High
Date Added:
09/17/2024
Dartanyon Crockett – The Fighter Within
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CC BY-NC
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Dartanyon Crockett, paralympic bronze medalist in Judo, rose to success out of a past filled with disappointment and hardship. Legally blind, he struggled in school until he found a Natural High in wrestling and eventually Judo. Dartanyon continues to live a resilient lifestyle and inspires others to thrive no matter what circumstances they find themselves in.

How to use our resources:
1) Watch a dynamic video featuring a powerful, personal story
2) Discuss the video in a group using provided discussion guides
3) Engage in deeper learning through fun, interactive activities that reinforce the concepts from the video.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lesson
Unit of Study
Author:
Natural High
Date Added:
09/03/2024