This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Autophagy is a critical process in healthy human cells that removes excess organelles and substances while generating energy. But in cancer cells, autophagy can either feed growing tumors—literally supplying energy—or suppress them by clearing out cancer-promoting substances. Recently, researchers examined this process in non-small cell lung cancer (NSCLC) and focused on GNIP1, a TRIM family protein. Other TRIM proteins have been associated with autophagy previously, but this is the first autophagy study to examine GNIP1. GNIP1 expression was elevated in tumor cells from NSCLC patients, and clinically, it was associated with poor prognosis and survival time. Induced overexpression of GNIP1 in cultured NSCLC cells increased the cancerous behaviors proliferation and migration. Additional cell culture experiments indicated that GNIP1 did this by enhancing autophagy. Specifically, GNIP1 mediated the breakdown of the VPS34 complex, an autophagy inhibitor..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This course explores how gender shaped the historical experiences and cultural productions in the North American West during the time it was being explored, settled, and imagined. The North American West of the late nineteenth and early twentieth centuries provides a fascinating case study of the shifting meanings of gender, race, citizenship, and power in border societies. As the site of migration, settlement, and displacement, it spawned contests over land, labor disputes, inter-ethnic conflicts and peaceful relations, and many kinds of cultural productions.
The Graduate Consortium in Women’s Studies (GCWS)
This course is part of the Graduate Consortium in Women’s Studies. The GCWS at MIT brings together scholars and teachers at nine degree-granting institutions in the Boston area who are devoted to graduate teaching and research in Women’s Studies and to advancing interdisciplinary Women’s Studies scholarship. Learn more about the GCWS.

This course uses theories of gender to explore sociopolitical, ethical and theological perspectives on immigration policy, with a focus on the U.S. The course begins with an overview of global developments in the feminization of migration and ethical and policy dilemmas that are specific to the current era.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Glioblastomas are deadly, malignant brain tumors. Even with current treatment methods, the median life expectancy after diagnosis is only 15 months. This extreme treatment resistance is primarily due to changes in the tumor microenvironment (TME). Glioblastomas sometimes recruit normal cells to aid growth, and neural progenitor cells (NPCs) have been observed migrating toward glioblastomas. Understanding the interaction between tumor and non-tumor cells in the TME is critical to developing new treatments. Recently, researchers examined the effects of extracellular vesicles (EVs) from glioblastoma cell lines on the cell lines themselves and mouse NPCs (mNPCs). In both glioblastoma cell lines and mNPCs, glioblastoma-derived EVs promoted proliferation and migration. Using a combination of proteomic profiling and laboratory assays, researchers examined the potential mechanisms of this effect and identified the PI3K-Akt-mTOR pathway as a key mediator..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Tracing the evolution of international interactions, this course examines the dimensions of globalization in terms of scale and scope. It is divided into three parts; together they are intended to provide theoretical, empirical, and policy perspectives on source and consequences of globalization, focusing on emergent structures and processes, and on the implications of flows of goods and services across national boundaries – with special attention to the issue of migration, on the assumption that people matter and matter a lot. An important concern addressed pertains to the dilemmas of international policies that are shaped by the macro-level consequences of micro-level behavior. 17.411 fulfills undergraduate public policy requirement in the major and minor. Graduate students are expected to explore the subject in greater depth through reading and individual research.

Tracing the evolution of international interactions, this course examines the dimensions of globalization in terms of scale and scope. It is divided into three parts; together they are intended to provide theoretical, empirical, and policy perspectives on source and consequences of globalization, focusing on emergent structures and processes, and on the implications of flows of goods and services across national boundaries – with special attention to the issue of migration, on the assumption that people matter and matter a lot. An important concern addressed pertains to the dilemmas of international policies that are shaped by the macro-level consequences of micro-level behavior. 17.411 fulfills undergraduate public policy requirement in the major and minor. Graduate students are expected to explore the subject in greater depth through reading and individual research.

In this writing-based unit, students will reflect on how global issues influence their lives through the lens of migration. Students will make personal connections to migration by exploring its impact on themselves and their families through research and interviews, resulting in a feature article on the theme of “My Personal Story of Migration.” This will encourage a “citizen of the world” mindset while developing positive identity awareness.

This collection uses primary sources to explore John Steinbeck's novel, The Grapes of Wrath. Digital Public Library of America Primary Source Sets are designed to help students develop their critical thinking skills and draw diverse material from libraries, archives, and museums across the United States. Each set includes an overview, ten to fifteen primary sources, links to related resources, and a teaching guide. These sets were created and reviewed by the teachers on the DPLA's Education Advisory Committee.

The theme of this guide is the education and investigation of whale adaptations to natural and man-made migration obstacles.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The protein HHEX plays multiple roles in development, gene expression, and cancer suppression. For example, it can inhibit breast cancer and prostate cancer cell migration and invasion, which are important processes for cancer spread, but whether and how HHEX affects lung cancer cell motility remain unknown. To learn more, a new study investigated HHEX’s functions in human non-small cell lung cancer cells and control cells. According to an analysis of published datasets, HHEX expression was reduced in lung cancer cells, and low HHEX expression was associated with reduced overall survival in patients. In lung cancer cell lines, silencing HHEX accelerated wound gap closure and increased protrusion formation, indicating increased migration ability, while HHEX overexpression had the opposite effects..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Residing in the stomachs of over half the human population, the bacterium Helicobacter pylori, also known as H pylori, has become a major cause of digestive complications, ranging from peptic ulcers to stomach cancer. But despite this link, scientists still aren’t sure how these disorders arise after infection. Now, researchers have homed in on a single protein produced by H pylori that seems to rev up the immune system, causing a state of inflammation that may pave the way for cancer growth or other types of gut breakdown. The protein, HP1454, is naturally released from H pylori -- both actively by living cells and passively as cells die. The scientists found that when special immune cells known as T cells encounter this secreted HP1454, they kick into action, mounting an inflammatory response. This relationship was particularly strong in people with stomach cancer..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This article discusses the physical and behavioral adaptations that allow birds to survive in cold climates such as the polar regions.

Human Geography: An open textbook for Advanced Placement is aligned to the 2015  College Board course articulation for AP Human Geography. The purpose of  AP Human Geography is to introduce students to the systematic study of patterns and processes that have shaped human understanding, use, and alteration of Earth's surface. Students employ spatial concepts and landscape analysis to examine human social organization and its environmental consequences. They also learn about the methods and tools geographers use in their science and practice.

Final video in a series from 23andMe and Khan Academy that introduces human prehistory, this video describes how when people started crossing oceans, genetic and cultural differences between people from different continents began fading.

Second in a series of videos from Khan Academy and 23andMe, this video introduces human prehistory, this video describes how our human ancestors spread throughout Africa and then into other regions such as Australia and Europe. How did they reach Australia so early on? What happened when our ancestors encountered Neanderthals?

Third in a series of videos from Khan Academy and 23andMe that introduces human prehistory, this video describes how early humans continued to defy the odds and populated the Americas during the last ice age.

Fourth in a series of videos from Khan Academy and 23andMe that introduces human prehistory, this video describes how agriculture changed human societies and genetics throughout the world.

Almost everywhere on the world, international migration is a hot topic. Most of the time the debate about migration is fierce and charged with prejudices and fears. At the political level, this has far-reaching consequences, ranging from electoral victories of populist right-wing parties to the increasing isolation policy of Europe and the United States. But what exactly is migration? What are its causes? And what are problems and opportunities?

This session will expand the student´s knowledge about human health and quality of life in the context of global and local ecology. Examples will be provided on how environmental management and development influence human health. The session provide an overview of the disease burden attributable to the environment, and much of this burden is placed across different geographical regions of the world. Examples will be presented on the impacts of poor quality water, insufficient access to water, lack of appropriate sanitation and poor personal hygiene. Other examples of environmental health factors included relate to reduced forest cover, unsustainable agricultural production systems, climate change, and poor management of natural resources that significantly influence livelihood, food security and migration patterns.

The video introduces health challenges for the very varied group of migrants. A large part voluntarily migrated, but non-voluntary groups include refugees, IDPs, Stateless and trafficked persons. Internal migrants are both due to conflicts and disasters and general urbanisation. The different groups have very varied health issues, and also very varied protective frameworks – whether international conventions or national laws and services - and may not be able or willing to seek health care.