This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Neuroblastoma is a childhood tumor that forms in the neural crest during early development. While treatment has remained elusive, scientists do know that a partially deleted chromosome 11 contributes to one of the most aggressive forms of neuroblastoma. Here, researchers now say, lies an important gene whose absence gives rise to runaway tumor cell growth. That gene is discs large homolog 2, or DLG2. DLG2 and other genes in its family play important roles in cell structure and growth. DLG2 gene transfection experiments slowed the growth of neuroblastoma cells, whereas silencing DLG2 promoted neuroblastoma growth. A closer look revealed that low DLG2 expression fast-tracks cells through the growth phase of the cell cycle, bypassing a critical checkpoint designed to catch faulty DNA. A review of real-world patient data showed that low DLG2 expression is in fact correlated with poor survival in patients with neuroblastoma..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Microbiomes are more than just prokaryotes and viruses; they also contain important eukaryotes, including fungi and protists. However, eukaryotes are difficult to study using ‘shotgun’ metagenomics, as their signal is often overwhelmed by the prokaryotes. Some methods use eukaryote-specific marker genes, but they can’t detect eukaryotes that aren’t in the reference marker gene set, and such methods are not compatible with web-based tools for downstream analysis. But CORRAL (Clustering Of Related Reference ALignments) is designed to close those gaps. CORRAL identifies eukaryotes in metagenomic data based on alignments to eukaryote-specific marker genes and Markov clustering. It can detect microbial eukaryotes that are not included in the marker gene reference set. The process is even automated and can be carried out at scale. A recent paper demonstrates CORRAL’s sensitivity and accuracy with simulated datasets, mock community standards, and human microbiome datasets..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Barrangou and a team of researchers at Danisco first experimentally demonstrated the technique of CRISPR (Clusters of Regularly Interspaced Short Palindromic Repeats). To fight off the infecting bacteriophages, the bacterial immume systems (CRISPR-Cas9) specifically target genomic sequences. Cas9 is an enzyme that cuts DNA which is associated with the specialized stretches of CRISPR DNA.
This figure clearly depicts how the bacterium protects itself from the infecting viruses (bacteriophages).

The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. The assigned readings will provide concrete examples of the experimental approaches and logic used to establish these findings. Some examples of topics include genome and systems biology, transcription, and gene expression.

Instructions on how to extract DNA from students cheek cells. Includes follow-up questions.

Overview of DNA transcription, translation, and replication during mitosis and meiosis. Learn about chromosomes, chromatids, and chromatin.

The topic of this video module is how to classify animals based on how closely related they are. The main learning objective is that students will learn how to make phylogenetic trees based on both physical characteristics and on DNA sequence. Students will also learn why the objective and quantitative nature of DNA sequencing is preferable when it come to classifying animals based on how closely related they are. Knowledge prerequisites to this lesson include that students have some understanding of what DNA is and that they have a familiarity with the base-pairing rules and with writing a DNA sequence.

This genomics education lesson plan was formulated and tested on some year 6 students with the help of their teacher Michelle Pardini at the Hong Kong ICS School. Using the example of the ongoing citizen science Bahinia Genome project from Hong Kong it hopes to serve as a model to inspire and inform other national genome projects, and aid the development of crucial genomic literacy and skills across the globe. Inspiring and training a new generation of scientists to use these tools to tackle the biggest threats to mankind: climate change, disease, and food security. It is released under a CC-BY SA 4.0 license, and utilised the following slide deck and final quiz. Promoting open science, all of the data and resources produced from the project is immediately put into the public domain. Please feel free to utilise, adapt and build upon any of these as you wish. The open licence makes these open education resources usable just with attribution and posting of modified resources under a similar manner. Contact BauhiniaGenome if you have any questions or feedback.Bauhinia Genome overviewFor a slidedeck for the lesson plan laid out here you can use the set in slideshare here.

The course focuses on casting contemporary problems in systems biology and functional genomics in computational terms and providing appropriate tools and methods to solve them. Topics include genome structure and function, transcriptional regulation, and stem cell biology in particular; measurement technologies such as microarrays (expression, protein-DNA interactions, chromatin structure); statistical data analysis, predictive and causal inference, and experiment design. The emphasis is on coupling problem structures (biological questions) with appropriate computational approaches.

This is information to be used for a General Biology I (or Introduction to Biology) course for non-science majors.

This series of instructional videos was created by Camosun College for a Canadian edition of the OpenStax "Concepts of Biology" open textbook as part of the BC Open Textbook Project. The lectures are taught by Charles Molnar, a Biology instructor at Camosun College. The videos are accompanied by transcripts.

This lesson plan engages students in constructing a simple DNA model using everyday objects like licorice, gummy candies, and toothpicks. By creating a hands-on representation of the DNA double helix, students will learn about the basic structure and function of DNA, including the concepts of base pairing and genetic coding. The activity fosters creativity, and problem-solving skills while making complex biological concepts accessible and fun.  

Learn about DNA (deoxyribonucleic acid). Overview of DNA bases, complementary base pairing, and the structure of the double helix.

Students reinforce their knowledge that DNA is the genetic material for all living things by modeling it using toothpicks and gumdrops that represent the four biochemicals (adenine, thiamine, guanine, and cytosine) that pair with each other in a specific pattern, making a double helix. They investigate specific DNA sequences that code for certain physical characteristics such as eye and hair color. Student teams trade DNA "strands" and de-code the genetic sequences to determine the physical characteristics (phenotype) displayed by the strands (genotype) from other groups. Students extend their knowledge to learn about DNA fingerprinting and recognizing DNA alterations that may result in genetic disorders.

Students perform DNA forensics using food coloring to enhance their understanding of DNA fingerprinting, restriction enzymes, genotyping and DNA gel electrophoresis. They place small drops of different food coloring ("water-based paint") on strips of filter paper and then place one paper strip end in water. As water travels along the paper strips, students observe the pigments that compose the paint decompose into their color components. This is an example of the chromatography concept applied to DNA forensics, with the pigments in the paint that define the color being analogous to DNA fragments of different lengths.

 DNA Model Grade Level: 10thSubject: ALS:AnimalsDuration: 100 minutesDOK Level:4SAMR Level: Substitution Indiana Standard: ALSA-2.23 Explain the importance of DNA and differentiate the following terms, genome, gene, chromatin, chromosome, and chromatids.Objective: Students will be able to design and construct a DNA model with 100% accuracy.Essential Question: What is DNA?Procedure: Have students write down everything they know about DNAShow the video DNA Chalk Talk Present the lecture DNA BasicsDivide the students into pairsExplain the expectations of the DNA modelBrainstorming sheetWritten out planParagraph explaining the model and relating it the real DNA. The paragraph also needs to explain why the pieces of the model were used.Allow the students the rest of the time to create a brainstorming sheet and plan for building the next class timeAllow one class period for building and presentingProduct or Assessment: Students will be evaluated on their models and written paragraph. 

This short lesson is a modeling exercise to understand the structure of DNA and its relationship to nanoscale.

Many biotechnology applications rely on the DNA replication process.  Through this lesson, students will better understand the DNA replication process and connect it to other biotechnology processes.