Students are presented with an engineering challenge that asks them to develop a material and model that can be used to test the properties of aortic valves without using real specimens. Developing material that is similar to human heart valves makes testing easier for biomedical engineers because they can test new devices or ideas on the model valve instead of real heart valves, which can be difficult to obtain for research. To meet the challenge, students are presented with a variety of background information, are asked to research the topic to learn more specific information pertaining to the challenge, and design and build a (prototype) product. After students test their products and make modifications as needed, they convey background and product information in the form of portfolios and presentations to the potential buyer.

Students learn how forces affect the human skeletal system through fractures and why certain bones are more likely to break than others depending on their design and use in the body. They learn how engineers and doctors collaborate to design effective treatments with consideration for the location, fracture severity and patient age, as well as the use of biocompatible materials. Learning the lesson content prepares students for the associated activity in which they test small animal bones to failure and then design treatment repair plans.

This course reviews the key genomic technologies and computational approaches that are driving advances in prognostics, diagnostics, and treatment. Throughout the semester, emphasis will return to issues surrounding the context of genomics in medicine including: what does a physician need to know? what sorts of questions will s/he likely encounter from patients? how should s/he respond? Lecturers will guide the student through real world patient-doctor interactions. Outcome considerations and socioeconomic implications of personalized medicine are also discussed. The first part of the course introduces key basic concepts of molecular biology, computational biology, and genomics. Continuing in the informatics applications portion of the course, lecturers begin each lecture block with a scenario, in order to set the stage and engage the student by showing: why is this important to know? how will the information presented be brought to bear on medical practice? The final section presents the ethical, legal, and social issues surrounding genomic medicine. A vision of how genomic medicine relates to preventative care and public health is presented in a discussion forum with the students where the following questions are explored: what is your level of preparedness now? what challenges must be met by the healthcare industry to get to where it needs to be?

Lecturers
Dr. Atul J. Butte
Dr. Steven A. Greenberg
Dr. Alvin Thong-Juak Kho
Dr. Peter Park
Dr. Marco F. Ramoni
Dr. Alberto A. Riva
Dr. Zoltan Szallasi
Dr. Jeffrey Mark Drazen
Dr. Todd Golub
Dr. Joel Hirschhorn
Dr. Greg Tucker-Kellogg
Dr. Scott Weiss

Students are challenged to think as biomedical engineers and brainstorm ways to administer medication to a patient who is unable to swallow. They learn about the advantages and disadvantages of current drug delivery methods—oral, injection, topical, inhalation and suppository—and pharmaceutical design considerations, including toxicity, efficacy, size, solubility/bioavailability and drug release duration. They apply their prior knowledge about human anatomy, the circulatory system, polymers, crystals and stoichiometry to real-world biomedical applications. A Microsoft® PowerPoint® presentation and worksheets are provided. This lesson prepares students for the associated activity in which they create and test large-size drug encapsulation prototypes to provide the desired delayed release and duration timing.

Students learn about the heart and its role at the center of the human cardiovascular system. In the associated activity, students play out a scenario in which they are biomedical engineers asked to design artificial hearts. They learn about the path of blood flow through the heart and use that knowledge to evaluate designs of artificial hearts on the market.

Students operate mock 3D bioprinters in order to print tissue constructs of bone, muscle and skin for a fictitious trauma patient, Bill. The model bioprinters are made from ordinary materials— cardboard, dowels, wood, spools, duct tape, zip ties and glue (constructed by the teacher or the students)—and use squeeze bags of icing to lay down tissue layers. Student groups apply what they learned about biological tissue composition and tissue engineering in the associated lesson to design and fabricate model replacement tissues. They tangibly learn about the technical aspects and challenges of 3D bioprinting technology, as well as great detail about the complex cellular composition of tissues. At activity end, teams present their prototype designs to the class.

A main concern of shoe engineers is creating shoes that provide the right amount of arch support to prevent (or fix) common gait misalignments that lead to injury. During this activity, students look at their own footprints and determine whether they have either of the two most prominent gait misalignments: overpronation (collapsing arches) or supination (high arches). Knowing the shape of a person's foot, and their natural arch movement is necessary to design shoes to fix these gain alignments.

In this lesson on the brain's neural networks, students investigate the structure and function of the neuron. They discover ways in which engineers apply this knowledge to the development of devices that can activate neurons. After a review of the nervous system specifically its organs, tissue, and specialized cells, called neurons students learn about the parts of the neuron. They explore the cell body, dendrites, axon and axon terminal, and learn how these structures enable neurons to send messages. They learn about the connections between engineering and other fields of study, and the importance of research, as they complete the lesson tasks.

Students are introduced to a challenge question. Towards answering the question, they generate ideas for what they need to know about medicines and how they move through our bodies, watch a few short videos to gain multiple perspectives, and then learn lecture material to obtain a basic understanding of how antibiotics kill bacteria in the human body. They learn why different forms of medicine (pill, liquid or shot) get into the blood stream at different speeds.

Student teams design and conduct quality-control experiments to test the reliability of several ultraviolet protection factors. Students use UV-detecting beads in their experimental designs to test the effectiveness of various types of sunscreens and sunblock. For example, they might examine zinc oxide nanoparticles versus traditional organic sun protection factors. UV intensity is quantitatively measured by UVA and UVB Vernier sensors, and students record and graph their results. By designing and conducting this experiment, students compare various substances, while learning about quality control.

Students continue the research begun in the associated lesson as if they were biomedical engineers working for a pharmaceutical company. Groups each perform a simple chemical reaction (to precipitate solid calcium out of solution) to observe what may occur when Osteopontin levels drop in the body. With this additional research, students determine potential health complications that might arise from a new drug that could reduce inflammatory pain in many patients, improving their quality of life. The goal of this activity is to illustrate biomedical engineering as medical problem solving, as well as emphasize the importance of maintaining normal body chemistry.

Students conduct their own research to discover and understand the methods designed by engineers and used by scientists to analyze or validate the molecular structure of DNA, proteins and enzymes, as well as basic information about gel electrophoresis and DNA identification. In this computer-based activity, students investigate particular molecular imaging technologies, such as x-ray, atomic force microscopy, transmission electron microscopy, and create short PowerPoint presentations that address key points. The presentations include their own explanations of the difference between molecular imaging and gel electrophoresis.

Acting as if they are biomedical engineers, students design and print 3D prototypes of pressure sensors that measure the pressure of the eyes of people diagnosed with glaucoma. After completing the tasks within the associated lesson, students conduct research on pressure gauges, apply their understanding of radio-frequency identification (RFID) technology and its components, iterate their designs to make improvements, and use 3D software to design and print 3D prototypes. After successful 3D printing, teams present their models to their peers. If a 3D printer is not available, use alternate fabrication materials such as modeling clay, or end the activity once the designs are complete.

This presentation discusses how the political instability has an impact on health care services. It focuses upon a period in Uganda where the government health facilities were neglected resulting in the lack of adequate health care provision and access to medicines. Following the instability in the country, the development and management of its health care services was highly dependent on funding from external donors and significant international influence on national services, including health care programs.
Participants: Professor Susan Whyte.

Students learn about the current applications and limitations of 3D bioprinting, as well as its amazing future potential. This lesson, and its fun associated activity, provides a unique way to review and explore concepts such as differing cell functions, multicellular organism complexity, and engineering design steps. As introduced through a PowerPoint® presentation, students learn about three different types of bioprinters, with a focus on the extrusion model. Then they learn the basics of tissue engineering and the steps to design printed tissues. This background information prepares students to conduct the associated activity in which they use mock-3D bioprinters composed of a desktop setup that uses bags of icing to “bioprint” replacement skin, bone and muscle for a fictitious trauma patient, Bill. A pre/post-quiz is also provided.

Using ordinary household materials, student “biomedical engineering” teams design prototype models that demonstrate semipermeability under the hypothetical scenario that they are creating a teaching tool for medical students. Working within material constraints, each model consists of two layers of a medium separated by material acting as the membrane. The competing groups must each demonstrate how water (or another substance) passes through the first layer of the medium, through the membrane, and into the second layer of the medium. After a few test/evaluate/redesign cycles, teams present their best prototypes to the rest of the class. Then student teams collaborate as a class to create one optimal design that reflects what they learned from the group design successes and failures. A pre/post-quiz, worksheet and rubric are provided.

Students learn how crystallization and inhibition occur by examining calcium oxalate crystals with and without inhibitors that are capable of altering crystallization. Kidney stones are composed of calcium oxalate crystals, and engineers and doctors experiment with these crystals to determine how growth is affected when a potential drug is introduced. Students play the role of engineers by trying to determine which inhibitor would be the best for blocking crystallization.

Students work as biomedical engineers to find liquid solutions that can clear away polyvinyl acetate polymer "blood clots" in model arteries (made of clear, flexible tubing). Teams create samples of the "blood clot" polymer with different concentrations to discover the concentration of the model clot and then test a variety of liquids to determine which most effectively breaks down the model blood clot. Students learn the importance of the testing phase in the engineering design process, because they are only given one chance to present the team's solution and apply it to the model blood clot.

Students learn the function of the liver and how biomedical engineers can use liver regeneration to help people. Students test the effects of toxic chemicals on a beef liver by adding hydrogen peroxide to various liver and salt solutions. They observe, record and graph their results.

Students are given an engineering challenge: A nearby hospital has just installed a new magnetic resonance imaging facility that has the capacity to make 3D images of the brain and other body parts by exposing patients to a strong magnetic field. The hospital wishes for its entire staff to have a clear understanding of the risks involved in working near a strong magnetic field and a basic understanding of why those risks occur. Your task is to develop a presentation or pamphlet explaining the risks, the physics behind those risks, and the safety precautions to be taken by all staff members. This 10-lesson/4-activity unit was designed to provide hands-on activities to teach end-of-year electricity and magnetism topics to a first-year accelerated or AP physics class. Students learn about and then apply the following science concepts to solve the challenge: magnetic force, magnetic moments and torque, the Biot-Savart law, Ampere's law and Faraday's law. This module is built around the Legacy Cycle, a format that incorporates findings from educational research on how people best learn.