This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The tick-borne parasite Theileria annulata can cause life-threatening illness in cows. Buparvaquone is the only available drug treatment, but the incidence of buparvaquone (BPQ) resistance is increasing so alternative therapies are needed. To help, researchers recently tested the efficacy of the anti-malaria drug artemisinin and its derivatives against T. annulata infection. Artemisinin itself wasn’t effective, but all of its derivatives were able to selectively kill parasite-infected cells. Artesunate (ARS) and dihydroartemisinin (DHART) were especially potent and either drug could act synergistically with BPQ, enhancing the parasite-killing effects of the individual compounds. Investigation of the mechanism revealed that ARS and DHART caused oxidative stress and DNA damage in the infected cells which activated the protein p53 and the caspase-dependent cell death pathway..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Although the information on this page is based around the anatomy of the canine hindlimb, it is essentially the anatomy of the arteries in domestic species. Any major differences will be discussed on their respective pages

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies, and 40% of cases are related to mutation of the oncogene KRAS. However, no KRAS-targeting drugs are currently available for cancer treatment, and patients with KRAS mutations are insensitive to anti-EGFR therapy, which is often used for CRC. To improve treatment options, a new study tested the combined effects of the drugs artesunate and WNT974 on KRAS-mutant CRC. In vitro, the combination synergistically reduced CRC growth and decreased KRAS protein levels and activity, while inducing KRAS degradation via the ubiquitin–proteasome pathway, thereby reducing the oncogene’s influence. Specifically, the induced KRAS degradation was mediated by upregulation of ANAPC2, as well as upregulation of β-TrCP and GSK-3β. In addition, the combination treatment suppressed the PI3K/Akt/mTOR pathway, which is downstream of KRAS and supports tumor growth..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Despite their known benefits, chemotherapy and other cancer treatments can take a toll on patients. Side effects such as hair loss, nausea, immune system suppression, fatigue, cognitive impairment, and infertility are common. The reason is that many cancer-fighting treatments target cells that quickly reproduce, which is true of cancer cells but also of other, healthy cells in the body, including blood cells and those lining the gastrointestinal tract. Is it possible to target only cancerous tissues with therapeutic drugs so that healthy organs remain unaffected? Researchers at the RIKEN Cluster for Pioneering Research in Japan are engineering molecules to do just that. The team showed that artificially designed gold-based enzymes (or metalloenzymes) can be used to guide drug delivery through a technique called selective cell tagging therapy. These metalloenzymes are studded with sugar molecules that can bind to specific proteins called lectins displayed on the surface of cancer cells..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Artificial intelligence is transforming our way of life. Able to spot patterns invisible to the human eye, algorithms are learning how to make our lives easier, safer, and more fun. That power is not lost on materials researchers. During the next decade, artificial intelligence or AI-driven research could fundamentally transform how new and better materials are developed. What’s more, it might even revamp how materials research itself is carried out, enabling promising new materials and processes to be developed more quickly. Machine learning methods come in a variety of flavors, with some requiring more guidance, or “supervision,” from researchers. But, generally, a machine-learning algorithm designed to discover and understand the behavior of materials looks for patterns connecting the composition, structure, and properties of known materials..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This unit explores the various ways information and ideas about climate change are presented through a variety of media. This includes the evaluation of social media posts, research into climate change issues, and an exploration of contemporary art and artists. This was designed and taught in an honors 9th grade English Language Arts Classroom by Dr. Tavia Quaid in response to student interest in climate change and to reinforce key information literacy skills.

This unit explores the various ways information and ideas about climate change are presented through a variety of media. This includes the evaluation of social media posts, research into climate change issues, and an exploration of contemporary art and artists. 

The visual narratives and abstractions of this preeminent African American artist explore the places where he lived and worked: the rural South, Pittsburgh, Harlem, and the Caribbean. Bearden's central themes: religion, jazz and blues, history, literature, and the realities of black life he endured throughout his remarkable career in watercolors, oils, and especially collages and photomontages from the 1940s through the 1980s.

A puzzling caricature, probably dealing with Reconstruction under Andrew Johnson's administration. The work is quite crudely drawn. An acrobat, with mustache and sideburns and wearing a jester's cap, holds in each hand a mask, one grinning and one frowning. His legs stretch from the head of Pennsylvania congressman Thaddeus Stevens, who holds a paper labeled "Committee of 15" and is seated on a black man, who crawls on all fours, to the head of an unidentified man (probably Johnson) who holds the U.S. Constitution. The latter's back is turned to the viewer and several geese, some alive and some dead, appear at his feet. Stevens, an abolitionist, was one of the most prominent members of the Joint Committee on Reconstruction, composed of fifteen members of Congress. The fool remarks, "As yet, I have found no difficulty in standing upon my own platform."|Entered according to Act of Congress June 8th 1866.|Title appears as it is written on the item.|Weitenkampf, p. 153.|Forms part of: American cartoon print filing series (Library of Congress)|Published in: American political prints, 1766-1876 / Bernard F. Reilly. Boston : G.K. Hall, 1991, entry 1866-3.

Este é um E-book contendo diálogos de dois personagens num passeio pelo rio Sergipe em Aracaju/SE, de Tototó. Nesse passeio os dois personagens dialogam sobre o que percebem do ambiente no percurso, como os efluentes que são despejados no rio bem como, a beleza da paisagem. O passeio se inicia no terminal dos Tototós e finaliza no Largo da Gente Sergipana e nesse local os personagens conversam sobre a importância cultural do monumento e fazem algumas observações no que concerne às questões socioambientais.

This online database of our Asian Ethnographic collection includes artifacts that were found throughout the continent of Asia, from Russia to Indonesia, from Turkey to Japan. The database allows you to see all artifacts for a country by clicking on a map or list of country names, search by object type, culture, and keyword, find out what items are currently on display and learn about recently acquired artifacts. There are two ways to search the collection as a picture-only gallery, or as a catalog that describes each artifact's provenance (country, locale, culture), materials, dimensions, and year of acquisition.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Mosquito-borne illness kills more than 700,000 people per year. Often these pathogens reside in the mosquito gut, where they may be impacted by their diet and gut microbiome. But there are gaps in the research into these impacts. Specifically, most studies into mosquito sugar metabolism focused on blood diets, but only female mosquitos drink blood, while both sexes eat plant sugars like nectar and sap. Similarly, most mosquito microbiome research focused on bacteria, largely missing the potential role of gut fungi, or the mycobiome. To narrow these gaps, researchers examined fructose metabolism in Asian tiger mosquitoes using 13C-metabolomics and stable isotope probing. While female and male mosquitos had distinct metabolic pathways, the active fungal groups in both sexes after fructose ingestion had a mix of competitive and synergistic interactions. There was also evidence of cross-feeding interactions, where one microbial species produces metabolites that other microbes use..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

The artist conveys some of the profound disappointment and anger among Henry Clay's many supporters at the nomination of Zachary Taylor at the June 1848 Whig convention in Philadelphia. The convention's act was seen as a betrayal of the elder Whig statesman. In a scene based on act 3, scene 1 of Shakespeare's "Julius Caesar," the artist portrays Clay's opponents as treacherous conspirators stalking the unsuspecting statesman. Clay is pictured seated in the library of his estate at Ashland in Kentucky, reading the New York "Tribune," whose editor Horace Greeley was a Clay stalwart. Ten men with raised daggers prepare to attack him from behind. These include various Whig powers Daniel Webster, editor James Watson Webb, former New York mayor William V. Brady, Pennsylvania congressman David Wilmot, Kentucky senator and former Clay ally John J. Crittenden, and New York state party boss Thurlow Weed. Webster: "How many times shall Caesar bleed in sport" Webb: "Liberty! Freedom! Tyranny is dead!!!" Wilmot: "Go to the Pulpit Brutus" Brady: "And you too Cassius" Crittenden: "Stand fast together, lest some friend of Caesar's Should Chance" Weed: "By the necessity of my Nature, Your Enemy".|Drawn by "W.J.C."|Entered . . . 1848 by H.R. Robinson.|Published by H.R. Robinson 31 Park Row, (Opposite the Park Fountain) N. York.|Title appears as it is written on the item.|Lorant, p. 188.|Weitenkampf, p. 93.|Forms part of: American cartoon print filing series (Library of Congress)|Published in: American political prints, 1766-1876 / Bernard F. Reilly. Boston : G.K. Hall, 1991, entry 1848-22.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Microbial metagenomes are like a blueprint of all the functions performed by a microbial community. Some microbes can't be grown in the lab, so metagenomics is important for investigating otherwise-unknown microbial "dark matter". Short-read sequencing provides large amounts of data, but it's hard to assemble into complete genomes. A recent study combined short-read data with nanopore long-read data using Iterative Hybrid Assembly (IHA). The researchers reconstructed 49 metagenome-assembled genomes (MAGs), including some with very low coverage. In total, 34 MAGs did not belong to any known genus, representing unknown microbe groups. The IHA method revealed more of the genes present than a short-read-only approach and showed that the anammox genome of genus Ca. Brocadia contains two identical hydrazine synthase genes. The current method is best for enriched microbial communities and will be extended to high-complexity samples in the future..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This easy-to-understand video animation describes drought and explains the different categories of drought used by the drought monitor. It discusses the effects of and contributions to drought, what the implications of the different drought levels are, and puts the drought maps into context to understand how the impacts vary geographically (e.g. drought in Nevada vs Kansas - one could affect tourism, the other agriculture). It also touches on how the development of maps/drought severity is determined and how it might vary geographically. The animation provides a basic overview of statistics and percentiles and the concept of '100 year events.'

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Research is increasingly showing the impact of the microbiome -- the diverse microbial communities living within the gut -- on human health. But, _when_ and _how_ is the microbiome established? Two opposing hypotheses have been put forward. For over a century, the prevailing thought has been that the human fetal environment is sterile and that microbes are acquired during and after birth. If this view is correct, the microbiome of infants born via C-section should differ from those born vaginally. Recent studies using molecular techniques, however, suggest that bacterial communities may be present in the placenta, amniotic fluid, and the baby’s first stool. They posit that the acquisition of the gut microbiome, therefore, begins _in utero_. If this is the case, delivery method should have less of an effect on early microbiome assembly..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Consuming high amounts of red meat is commonly linked to an increased risk of developing cancer, especially colorectal cancer. At the same time, antibodies against Neu5Gc , a carbohydrate derived from red meat, have been observed to worsen cancer in “human-like” mice. While these antibodies and red meat consumption are each believed to increase cancer risk, it remains unknown how diet affects the antibodies. Now, research suggests that consuming Neu5Gc from red meat and dairy can modulate the amounts and properties of anti-Neu5Gc antibodies in humans, providing clues to how the carbohydrate might be linked to cancer. The team behind the study calculated daily intake of Neu5Gc for more than 19,000 subjects aged 18 years or older. These participants provided regular logs of food consumed over 24-hour periods as part of the NutriNet-Santé study, which was designed to investigate relationships between nutrition and health status..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"SARS-CoV-2 is the notorious virus responsible for the COVID-19 pandemic. Like other viruses, it coexists with a multitude of other microorganisms that could influence our susceptibility to infection. Thus, identifying associations between bacteria and SARS-CoV-2 could lend critical insight for the development of strategies for COVID-19 prevention and treatment. To meet this need, researchers recently characterized the microbial communities associated with COVID-19 patients, health care providers, and indoor surfaces in the hospital environment using 16S rRNA sequencing. They found SARS-CoV-2 RNA on 16% of the surfaces in COVID-19 patient rooms, with the highest prevalence in floor samples and lower prevalence on bed rails. SARS-CoV-2-positive samples had higher bacterial diversity than SARS-CoV-2-negative samples. Interestingly, bacteria in the genus Rothia were commonly found in the samples containing SARS-CoV-2, suggesting the existence of an association between these microorganisms..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"In the human gut, a subpopulation of the microbiome belonging to Archaea produces methane through fermentation. Increased methane production is associated with gastrointestinal discomfort and disorders, and 20% of the healthy Western population exhales high methane levels, indicating high gut methane production. However, the mechanisms and health effects are unclear. To learn more, a recent study analysed 100 healthy young adults who were divided into high methane emitters and low methane emitters according to breath analysis. 16S rRNA sequencing revealed that the microbiomes of high and low emitters had different diversity levels and different compositions. Notably, the relative abundance of the archaeon Methanobrevibacter smithii was 1000-fold higher in high emitters than in low emitters, and M. smithii in the high emitters co-occurred with dietary fiber-degrading bacteria, including Ruminococcaceae and Christensenellaceae..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.