This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Renal cancer affects over 400,000 people each year, and new treatment options are needed. A new study unraveled a paradox taking place in the immune systems of cancer patients. Myeloid-derived suppressor cells (MDSCs), driven by tumor cells, have the ability to suppress the immune responses of T cells, preventing T-cell recognition of tumor cells and allowing immune escape. However, mice and humans with renal tumors do not experience systemic immunosuppression. Researchers used mice to examine renal cancer-derived exosomes (RDEs), extracellular vesicles derived from tumor cells. They found that the proportion and activity of MDSCs in the spleen and bone marrow changed after internalization of RDEs. RDE-stimulated MDSCs inhibited T cell proliferation and cytotoxicity, and these effects were antigen-specific and driven by the molecule HSP70 in RDEs and TLR2 on MDSCs, explaining the targeted immunosuppression of the renal cancer-specific immune response..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"The rapid spread of antimicrobial resistance (AMR) is a growing public health and environmental problem, except, presumably, in remote regions like Antarctica. Antarctica is considered the most pristine continent because of its minimal human activity confined to specific research stations, so it’s an ideal location to study the early mechanisms of AMR acquisition. Existing evidence suggests that although human gut bacteria have colonized native wildlife around research stations, AMR in birds and seals is minimal. However, the research so far has been limited, and the standards and methods used have varied widely. In addition, much of the continent remains unsampled, making a comprehensive AMR assessment impossible. Implementation of continent-wide standards for AMR reporting would help future studies produce meaningful and comparable results that can be used to understand AMR acquisition in other regions of the globe..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Antimicrobials are commonly used in agriculture and are important for animal health. This use drives most of the antimicrobial use globally and has led to an increase in antimicrobial resistance (AMR), including resistance to antimicrobials that are critical in human medicine. Researchers recently examined the AMR profiles of over 400 pigs, including wild boars, Tibetan pigs, and commercial pigs, under multiple rearing modes. They identified over a thousand potential antimicrobial resistance gene (ARG) sequences that belonged to 69 different drug resistance classes. From this dataset a few patterns emerged. Tetracycline resistance was the most enriched, but aminoglycoside resistance had the most unique ARGs. Farm-reared pigs had higher AMR levels than semi-free-range pigs or wild boars..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Antimicrobial resistance (AMR) is an increasingly serious threat to global public health. New resistance mechanisms reduce our ability to treat common infectious diseases. Although microorganisms possessing AMR genes are thought to have emerged from natural habitats, better understanding is needed. A new study sought to examine the consequences of introducing antimicrobials into natural environments. Using lichen – a model for well-defined micro-ecosystems consisting of hundreds of microbial species – researchers evaluated changes in microbial communities following exposure to different antimicrobials. They found that the native lichen microbiome comprises highly diverse and low-abundance intrinsic antimicrobial resistance genes (ARGs) to cope with antimicrobial pressure. Antimicrobial-specific shifts occurred in the structure and function of the microbiome following 10 days of exposure to antimicrobials..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Polyphenols are micronutrients found in a variety of plant-based foods, including red wine, chocolate, and green tea. Daily consumption of polyphenols offers several health benefits. The polyphenol EGCG, found in green tea, possesses anti-inflammatory properties and has been linked to a reduced risk of inflammatory bowel disease (IBD). But one important factor that’s remained underexplored in studies of EGCG is the effect of the gut microbiome. Now, a new study of gut microbes in mice may pave the way for understanding EGCG's anti-inflammatory effects in the intestine. Researchers first confirmed that feeding EGCG to mice with colitis alleviated symptoms of disease. Experiments then showed that EGCG altered the makeup and function of the intestinal microbial community. The team found that EGCG had the same protective and microbiome-altering effects even when given to mice before they developed colitis..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Radiation is a powerful therapy for fighting cancer. But it can prove toxic to tissues in the bone marrow and gastrointestinal tract, a condition known as acute radiation syndrome. In 2017, researchers discovered that transplanting fecal matter from healthy mice to mice with acute radiation syndrome can alleviate radiation toxicity. To find out how, the researchers analyzed fecal pellets from mice receiving radiation to treat tumors. They discovered elevated levels of indole 3-propionic acid, or IPA, a protective antioxidant produced by microbes in the gut, suggesting that IPA is lost following exposure to radiation. Administering IPA orally to irradiated mice recouped this loss. and produced notable improvements in the spleen and thymus of mice with acute radiation syndrome without accelerating tumor growth. The evidence suggests that administering IPA could be a safe way to prevent acute radiation syndrome during radiotherapy without requiring fecal matter transplantation..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
DNA is composed of two strands of nucleotides held together by hydrogen …
DNA is composed of two strands of nucleotides held together by hydrogen bonding. The strands each run from 5' to 3' and run in antiparallel, or opposite, directions from one another.
Esta guía práctica acompaña la serie de videos Poder estadístico y tamaño …
Esta guía práctica acompaña la serie de videos Poder estadístico y tamaño de muestra en R, de mi canal de YouTube Investigación Abierta, que recomiendo ver antes de leer este documento. Contiene una explicación general del análisis de poder estadístico y cálculo de tamaño de muestra, centrándose en el procedimiento para realizar análisis de poder y tamaños de muestra en jamovi y particularmente en R, usando los paquetes pwr (para diseños sencillos) y Superpower (para diseños factoriales más complejos). La sección dedicada a pwr está ampliamente basada en este video de Daniel S. Quintana (2019).
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Parasitic infections affect nearly 1 in 6 people worldwide. These infections thrive when parasites are able to evade, inhibit, or disrupt host defense mechanisms. One way parasites avoid the immune response is to disguise themselves as dying host cells. Normal host cells undergoing apoptosis expose a molecule called phosphatidylserine (PS) on the plasma membrane as a signal to surrounding cells. This signal is detected by phagocytic immune cells, which engulf the dying cell and reduce inflammation. The system is co-opted by parasites, who use PS as a Trojan horse to enter phagocytic immune cells, infecting the host. This process, known as “apoptotic mimicry, ”takes several forms. Classical apoptotic mimicry - where the PS comes from the challenger - is used by the parasites that cause leishmaniasis, American trypanosomiasis, and toxoplasmosis; while non-classical apoptotic mimicry, which co-opts PS exposed by dying host cells, is used by the parasites that cause malaria and amebiasis..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
In this problem set students are given Rb/Sr and 87Sr/86Sr data for …
In this problem set students are given Rb/Sr and 87Sr/86Sr data for whole rock and mineral samples from three granitic intrusions in the Sierra Nevada. They use these data (in EXCEL) to calculate isochron ages and initial ages for the intrusions and then interpret their results. This problem is intended to teach some spreadsheet skills (linear regressions, graphing) as well as having them think about the use of radiogenic isotopes.
(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Acute hepatopancreatic necrosis disease (AHPND) is an important bacterial disease of shrimp caused by some Vibrio species and has severe negative impacts on shrimp aquaculture globally. Antibiotics are commonly used prophylactically against such diseases but can cause bacterial antibiotic resistance and microbiome impairment. Given the risk of antibiotics to human and environmental health, the application of probiotics is a promising approach, but whether these probiotics affect the shrimp gut microbiome remains unknown. Recently, researchers examined how the shrimp gastrointestinal microbiota responded to the ILI strain, a Vibrio strain that also serves as an effective shrimp probiotic. The ILI strain was effective not only in preventing AHPND and promoting shrimp survival but also in maintaining a healthy gut microbiome..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This lab exercise provides students with activities utilizing vector operations within the …
This lab exercise provides students with activities utilizing vector operations within the context of the atmospheric and oceanic environments.
(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)
7.003 is an experimental biology course. You will spend most of your …
7.003 is an experimental biology course. You will spend most of your time in the teaching laboratory practicing fundamental techniques in molecular biology, genetics, and cell biology, and working with the model organism Saccharomyces cerevisiae (budding yeast). In addition to learning how to accurately and safely perform these techniques, we want to help you understand how and why they work and what scientific questions they can address. The goal is for you to be able to design your own experiments to perform by the end of the semester.
In this jigsaw-method activity on subduction zone volcanism, students apply lessons learned …
In this jigsaw-method activity on subduction zone volcanism, students apply lessons learned from four historic eruptions to the volcanic hazards associated with Mt. Rainier in the Pacific Northwest.
(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)
A series of 6 Excel-based projects on the mathematics of biodiversity for …
A series of 6 Excel-based projects on the mathematics of biodiversity for basic college math classes and developmental math classes. Students learn about the structure of biodiversity, the application of many basic data analysis skills, and the use of Excel for analysis and data presentation.
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