This guide to the Pacific Northwest Collection is for new and seasoned …
This guide to the Pacific Northwest Collection is for new and seasoned researchers. Find links and tips to navigate our collection databases and catalog. Discover exhibits and research ideas.
(This case study was added to OER Commons as one of a …
(This case study was added to OER Commons as one of a batch of over 700. It has relevant information which may include medical imagery, lab results, and history where relevant. A link to the final diagnosis can be found at the end of the case study for review. The first paragraph of the case study -- typically, but not always the clinical presentation -- is provided below.)
The patient is a 33 year old female who presented for a routine clinical evaluation during a twin pregnancy. The patient was asymptomatic otherwise and appeared to be in good health. The patient's gestational age was 22 weeks at clinical presentation. Routine laboratory investigation of the peripheral blood showed an absolute neutrophilia along with the following clinical laboratory values:
(This case study was added to OER Commons as one of a …
(This case study was added to OER Commons as one of a batch of over 700. It has relevant information which may include medical imagery, lab results, and history where relevant. A link to the final diagnosis can be found at the end of the case study for review. The first paragraph of the case study -- typically, but not always the clinical presentation -- is provided below.)
A 37-year-old woman had bilateral blurred vision with hazy vision gradually from periphery to center for two months. There was mixed horizontal and vertical diplopia. Ophthalmologic treatment did not help. We she came to us, an Humphrey visual field test disclosed bilateral temporal hemianopia. CT showed hyperdensity and heterogeneously enhanced sellar lesion with size 2.57 x 1.96 x 3.63 cm and supra-sellar extension. MRI T1 showed sella tumor with isointense signal mixed with the hyperintense part (Fig 1a). MRI T2 scans showed compression of the optic chiasm. With contrast, there was heterogeneous enhancement in the tumor. The clivus showed a heterogenously enhancing lesion was noted on T1 with contrast (Fig 1b).
(This case study was added to OER Commons as one of a …
(This case study was added to OER Commons as one of a batch of over 700. It has relevant information which may include medical imagery, lab results, and history where relevant. A link to the final diagnosis can be found at the end of the case study for review. The first paragraph of the case study -- typically, but not always the clinical presentation -- is provided below.)
A 46-year-old man presented with a 2 week history of bilateral lower extremity numbness and tingling. The patient had a past medical history significant for a right posterior fossa medulloblastoma diagnosed at the age of 24, treated with total resection and craniospinal radiation (5040 cGy to the posterior fossa, 3960 cGy to the whole brain, and 3420 cGy to the spine). Twenty-one years later, at the age of 45, the patient experienced progressive right lower extremity weakness and subsequent MRI showed an expansile intradural extramedullary enhancing 1.3 cm T5 level spinal cord lesion. This lesion was presumed to be recurrent medulloblastoma in the form of drop metastasis, and the patient underwent additional radiation to the tumor and a small surrounding margin (3750 cGy). Several months after treatment, at the age of 46, the patient experienced recurrent symptoms of lower leg weakness. A follow-up MRI revealed a 1.4 cm intradural extramedullary lesion at T7 with associated cord edema. Sagittal sequences performed after the administration of intravenous gadolinium chelate demonstrated subtle enhancement (Figure 1). In an effort to confirm the diagnosis of recurrent meduloblastoma and rule out radiation necrosis or a second malignancy as well as to help determine future treatment it was determined that histological confirmation was necessary. The patient underwent an uneventful thoracic laminectomy at T6-T7 with subtotal resection of the intradural lesion.
(This case study was added to OER Commons as one of a …
(This case study was added to OER Commons as one of a batch of over 700. It has relevant information which may include medical imagery, lab results, and history where relevant. A link to the final diagnosis can be found at the end of the case study for review. The first paragraph of the case study -- typically, but not always the clinical presentation -- is provided below.)
A 60 year-old man, without relevant medical history, noted a slight and progressive instability of gait for one month, and right hand clumsiness two weeks before admission.
(This case study was added to OER Commons as one of a …
(This case study was added to OER Commons as one of a batch of over 700. It has relevant information which may include medical imagery, lab results, and history where relevant. A link to the final diagnosis can be found at the end of the case study for review. The first paragraph of the case study -- typically, but not always the clinical presentation -- is provided below.)
A 55-year-old woman presented with bilateral hip and rib pain. A chest radiograph revealed multiple bilateral rib fractures with callus formation. Insufficiency fractures of the right superior and inferior pubic rami and ischium and possibly of the sacrum were noted on hip and pelvic radiographs, and a subsequent MRI showed avascular necrosis of the left femoral head. Laboratory studies demonstrating hypophosphatemia, in combination with the patient's clinical presentation of osteomalacia, prompted further investigation for the underlying cause.
(This case study was added to OER Commons as one of a …
(This case study was added to OER Commons as one of a batch of over 700. It has relevant information which may include medical imagery, lab results, and history where relevant. A link to the final diagnosis can be found at the end of the case study for review. The first paragraph of the case study -- typically, but not always the clinical presentation -- is provided below.)
A 64-year-old diabetic woman presented with progressive cognitive deterioration and gait ataxia. Symptoms appeared one month before admission, without hyperthermia. Clinical examination showed temporo-spatial disorientation, loss in attention, judgment and memory capacities, a gait ataxia with a kinetic cerebellar syndrome and a left side bradykinesia. There was neither pyramidal syndrome nor cranial nerve palsy. General examination was normal. Brain MRI (T1-wi with and without gadolinium, Flair and T2-wi) found a periventricular diffuse leukoencephalopathy (Figure 1A) without gadolinium enhancement (Figure 1B). EEG showed diffused slow waves and epileptic seizures without periodic paroxystic activity. Hematological and biological serum analyses (including LDH, beta2-microglobulinemia, fibrinogen, CRP, electrophoresis and immunoelectrophoresis of the proteins, transaminases, urea, creatinine, lymphocyte immunophenotyping) were normal. All serological investigations (HIV, HSV1 and HSV2, CMV, VZV, EBV, JC virus) remained negative. The CSF presented normal cell count (2 lymphocytes / mm3) and protein level (0,3 g / L), without abnormal cells or intrathecal protein synthesis except a positivity of 14.3.3 protein. The neurological state worsened progressively with dementia, epileptic seizures, extrapyramidal and cerebellar syndromes. The patient died three months after onset of symptoms, and an autopsy restricted to the brain was performed.
(This case study was added to OER Commons as one of a …
(This case study was added to OER Commons as one of a batch of over 700. It has relevant information which may include medical imagery, lab results, and history where relevant. A link to the final diagnosis can be found at the end of the case study for review. The first paragraph of the case study -- typically, but not always the clinical presentation -- is provided below.)
The patient is a preadolescent female who presented with nausea, vomiting, blurred vision, diplopia, gait instability and ataxia. An MRI showed a 22 x 21 x 78 mm enhancing tumor with a necrotic center located at the craniocervical junction expanding the medulla oblongata and the proximal aspect of the spinal cord to the level of T3. Additionally, there was a non-enhancing exophytic component of the tumor abutting the left premedullary cistern (Figure 1). The radiologic impression was an infiltrative, likely astrocytic, craniocervical junction tumor with an exophytic component.
(This case study was added to OER Commons as one of a …
(This case study was added to OER Commons as one of a batch of over 700. It has relevant information which may include medical imagery, lab results, and history where relevant. A link to the final diagnosis can be found at the end of the case study for review. The first paragraph of the case study -- typically, but not always the clinical presentation -- is provided below.)
A 48-year-old man with a history of hypertension, peripheral vascular disease and a 50-pack-year history of smoking, presented with new onset vertigo, tinnitus, diplopia and ataxia in January of 1978. There was no family history of any brain lesions, neurological symptoms or other contributory diseases. CT scan showed a radiolucent defect in the left cerebellar hemisphere with a possible mural nodule. In ensuing months, worsening symptoms were experienced with a corresponding increase in lesion size on re-imaging. Four months later, a left posterior fossa craniotomy was performed and revealed a single cystic lesion containing copious amounts of straw- colored fluid and a single mural nodule in the inferior portion of the cyst. Following resection, he was followed clinically until 1985 at which time follow-up was discontinued. He did well until January of 1993 when he presented with progressively worsening episodic headaches and retro-orbital pressure. In the following months, additional symptoms including slurred speech, left facial droop; upper and lower extremity weakness were documented. Subsequent MRIs of the brain (02/93, 03/93) showed diffuse nodular leptomeningeal enhancement in the posterior fossa. Multiple low intensity lesions coated the cerebellum, and similar lesions were located anterior to the pons, in the suprasellar cistern, at the tip of the temporal lobe, in the right Meckel's cave, and in the third ventricle (Figures 1, 2 and 3). In addition, an MRI of the spine (03/93) showed multiple extra-axial intradural enhancing nodules throughout the length of the thoracic cord, consistent with drop metastases. He was admitted for radiotherapy, receiving 2600 rads in 10 fractions over a 19- day period in March 1993. During this hospitalization, his hematocrit ranged from 53 to 61%, demonstrating polycythemia. Despite therapy, his condition progressively declined, and he succumbed. The family authorized consent for examination of the brain only at autopsy.
(This case study was added to OER Commons as one of a …
(This case study was added to OER Commons as one of a batch of over 700. It has relevant information which may include medical imagery, lab results, and history where relevant. A link to the final diagnosis can be found at the end of the case study for review. The first paragraph of the case study -- typically, but not always the clinical presentation -- is provided below.)
The patient was referred to our hospital for the first time in 2004 as an 8-year-old girl with headaches, nausea, and occasional vomiting. A marginally contrast enhancing mass, completely filling out the fourth ventricle, was detected on brain MRI. Gross total resection was achieved and based on the neuropathological diagnosis the patient underwent radiation and chemotherapy. One year later, progredient contrast enhancement was observed in the right cerebellar hemisphere at the bottom of the fourth ventricle, compatible with progredient residual tumor. These parts were again resected. Further cycles of chemotherapy followed, and the patient recovered well. However, 13 years after the first tumor presentation, the patient started to suffer from headaches and eye movement difficulties. On cranial MRI, a new contrast enhancing mass was found in the posterior fossa. Again, the tumor was resected and referred to histological examination. Shortly thereafter, a myelon-compressing intradural T8-T9 mass was detected and irradiation of the posterior fossa and the thoracic spine was started, when the patient presented with an acute transverse spinal cord syndrome. Resection of this spinal tumor was subsequently performed on an emergency basis. However, based on the rapidly progressive, especially meningeal tumor spread observed on MRI, supportive and palliative care was finally initiated.
Studies the role of the consumer in the economy and addresses problems …
Studies the role of the consumer in the economy and addresses problems of financing individual and family needs, including budgeting, banking relationships, charge accounts, installment buying, insurance, wills, real estate investing, and personal taxes.
Students use a light source, a polystyrene ball, and their bodies to …
Students use a light source, a polystyrene ball, and their bodies to model and explain the causes of eclipses and the phases of the moon, and then to determine the direction of the moon's revolution and the period of its rotation.
(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)
Word Count: 46737 (Note: This resource's metadata has been created automatically by …
Word Count: 46737
(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)
Chemistry 540 - Physical Organic Chemistry covers the principles of chemical bonding, …
Chemistry 540 - Physical Organic Chemistry covers the principles of chemical bonding, mechanisms of organic chemical reactions and stereochemistry. The important types of organic reactions are also discussed, with an emphasis on basic principles. As a part of this course, U-M students collaboratively created and editedWikipedia÷articles. Student contributions can be found below, within the "Wikipedia Articles" section.
The distribution of earthquakes and volcanoes around the world confirmed the theory …
The distribution of earthquakes and volcanoes around the world confirmed the theory of plate tectonics first proposed by Wegener. These phenomena also help categorize plate boundaries into three different types: convergent, divergent, and transform.
This activity is a slight variation on an original activity, Discovering Plate …
This activity is a slight variation on an original activity, Discovering Plate Boundaries, developed by Dale Sawyer at Rice University. I made different maps, including more detail in all of the datasets, and used a different map projection, but otherwise the general progression of the activity is the same. More information about jigsaw activities in general can be found in the Jigsaws module.
The activity occurs in several sections, which can be completed in one or multiple classes. In the first section, students are divided into "specialist" groups, and each group is given a global map with a single dataset: global seismicity, volcanoes, topography, age of the seafloor, and free-air gravity. Each student is also given a map of plate boundaries. Their task in the specialist group is to become familiar with their dataset and develop categories of plate boundaries based only on their dataset. Each group then presents their results to the class.
In the second section, students reorganize into groups with 1-2 of each type of specialist per group. Each new group is given a plate, and they combine their different datasets on that one plate and look for patterns. Again, each plate group presents to the class. The common patterns and connections between the different datasets quickly become apparent, and the final section of the activity involves a short lecture from the instructor about types of plate boundaries and why the common features are generated at those plate boundaries. A follow-up section or class involves using a problem-solving approach to explain the areas that don't "fit" into the typical boundary types - intra-plate volcanism, earthquakes in the Eastern California Shear Zone, etc.
(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)
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