In this seminar you will curate information on the types of mutation that best help you learn the information. A comparison of how harmful different types of mutation can be will generate a deeper understanding of each type. You will explore examples of authentic mutations and choose one to communicate your findings.StandardsBIO.B.2.2.1 Describe how the processes of transcription and translation are similar in all organisms.BIO.B.2.2.2 Describe the role of ribosomes, endoplasmic reticulum, Golgi apparatus, and the nucleus in the production of specific types of proteins.BIO.B.2.3.1 Describe how genetic mutations alter the DNA sequence and may or may not affect phenotype (e.g., silent, nonsense, frame-shift).

In this project, you will explore a real-world problem, and then work through a series of steps to analyze that problem, research ways the problem could be solved, then propose a possible solution to that problem. Often, there are no specific right or wrong solutions, but sometimes one particular solution may be better than others. The key is making sure you fully understand the problem, have researched some possible solutions, and have proposed the solution that you can support with information / evidence.Begin by reading the problem statement in Step 1. Take the time to review all the information provided in the statement, including exploring the websites, videos and / or articles that are linked. Then work on steps 2 through 8 to complete this problem-based learning experience.

A deep dive into how mRNA is translated into proteins with the help of ribosomes and tRNA.

The trp operon is a well-studied operon when it comes to gene regulation. It is involved in the biosynthesis of the amino acid tryptophan.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Undernourishment or undernutrition can be caused by a lack of food or a high energy demand, such as during pregnancy and lactation. Undernutrition in production animals disrupts metabolic homeostasis and causes serious health problems, including maternal metabolic disorders and stillbirth. Many production animals are ruminants, named for their unique digestive organ, the rumen, which houses a diverse anaerobic microbiome. The ruminal microbiome allows the host to break down hard-to-digest plant carbohydrates and produce protein that the host later absorbs. But little is known about the effects of undernutrition on the host-microbiome interaction in ruminants. A recent study investigated changes in the ruminal microbiome and epithelium in undernourished pregnant sheep. During undernutrition, the bacterial genes involved in the digestion of carbohydrates and protein synthesis were downregulated. This meant less energy and protein was available to the host and critical signaling pathways were inhibited..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In this seminar you will create a mental organization scheme to learn the central dogma theory in the steps of synthesizing proteins. Interactive games will help reinforce the process. You will model the process by creating coded (transcribing) secret messages and translating messages.StandardsBIO.B.2.2.1 Describe how the processes of transcription and translation are similar in all organisms.BIO.B.2.2.2 Describe the role of ribosomes, endoplasmic reticulum, Golgi apparatus, and the nucleus in the production of specific types of proteins.BIO.B.2.3.1 Describe how genetic mutations alter the DNA sequence and may or may not affect phenotype (e.g., silent, nonsense, frame-shift).