This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Archaea are single-celled organisms typically associated with extreme living environments. But many types make their home in the human body, including the gut. Unfortunately, what archaea are common and how they contribute to human health remain largely unknown. To gain a better idea, scientists used 16S rRNA gene deep sequencing to analyze fecal samples gathered from 897 East Asian people living in South Korea. Archaea made up nearly 10% of all microbes detected and displayed a surprisingly diverse membership. Most members were methane-producing archaea (green). But salt-loving “haloarchaea” (red) dominated several samples. Based on these variations in microbial community structure, samples could be classified into one of four types – or “enterotypes”. Future studies could help scientists refine these archaea enterotypes and understand their relationship to human health..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Advancements in next-generation sequencing have opened the door to detailed analyses of the human microbiome. This technique has many applications, and pancreatic cancer research is one of them. Pancreatic cancer is a devastating disease with an estimated 5-year survival rate of only 11%. Most cases, over 80%, are not found until the cancer is too advanced to successfully treat, but pancreatic cancer patients show shifts in their oral microbiome, which could be detected years earlier than current methods allow. Pathogenic oral bacteria have also been found within pancreatic tumors, which is another potential link between them. However, these findings barely scratch the surface of how the oral microbiome relates to pancreatic cancer. The oral microbiome is influenced by a combination of host-related and environmental factors, which include genetics, race, ethnicity, smoking, socioeconomics, and age..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Researchers have taken a significant step towards personalizing the treatment of cancer. Using DNA sequencing, they’ve developed a way to scan blood samples for mutations in circulating tumor DNA -- small bits of genetic material that are released as cancer cells die. The genomic reservoir contained in this DNA is representative of nearly all tumors carried by a patient, providing the foundation needed for comprehensive genetic profiling. Such profiling may help clinicians select the most appropriate therapies for a given patient. The genetic mutations giving rise todrivingthat drive cancer development often differ markedly among individuals. Interventions that match a patient’s unique genetic profile offer great promise, but obtaining tumor tissue for genetic testing can be invasive, and risky and sometimes impossible. To bypass these limitations, the researchers established a way to enrichextract, sequence, and analyze circulating tumor DNA..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.