This course explores the problem of intelligence—its nature, how it is produced by the brain and how it could be replicated in machines—using an approach that integrates cognitive science, which studies the mind; neuroscience, which studies the brain; and computer science and artificial intelligence, which study the computations needed to develop intelligent machines. Materials are drawn from the Brains, Minds and Machines Summer Course offered annually at the Marine Biological Laboratory in Woods Hole, MA, taught by faculty affiliated with the Center for Brains, Minds and Machines headquartered at MIT. Elements of the summer course are integrated into the MIT course, 9.523 Aspects of a Computational Theory of Intelligence.
Contributors
This course includes the contributions of many instructors, guest speakers, and a team of iCub researchers. See the complete list of contributors.

What does the brain look like? As engineers, how can we look at neural networks without invasive surgery? In this activity, students design and build neuron models based on observations made while viewing neurons through a microscope. The models are used to explain how each structure of the neuron contributes to the overall function. Students share their models with younger students and explain what a neuron is, its function, and how engineers use their understanding of the neuron to make devices to activate neurons.

This patient education program explains cerebral palsy (CP), the causes and risk factors, symptoms and complications, diagnosis, prevention, and treatment options. It also reviews brain anatomy, particularly that of the motor skills areas. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute.

This course is designed to provide an understanding of how the human brain works in health and disease, and is intended for both the Brain and Cognitive Sciences major and the non-Brain and Cognitive Sciences major. Knowledge of how the human brain works is important for all citizens, and the lessons to be learned have enormous implications for public policy makers and educators.
The course will cover the regional anatomy of the brain and provide an introduction to the cellular function of neurons, synapses and neurotransmitters. Commonly used drugs that alter brain function can be understood through a knowledge of neurotransmitters. Along similar lines, common diseases that illustrate normal brain function will be discussed. Experimental animal studies that reveal how the brain works will be reviewed.
Throughout the seminar we will discuss clinical cases from Dr. Byrne’s experience that illustrate brain function; in addition, articles from the scientific literature will be discussed in each class.

Cognitive Psychology is a psychological science which is interested in various mind and brain related subfields such as cognition, the mental processes that underlie behavior, reasoning and decision making.

Students continue their exploration of the human senses and their engineering counterparts, focusing on the auditory sense. Working in small groups, students design, create and run programs to control the motion of LEGO® TaskBots. By doing this, they increase their understanding of the use and function of sound sensors, gain experience writing robot programs, and reinforce their understanding of the sensory process.

Students learn about complex networks and how to represent them using graphs. They also learn that graph theory is a useful mathematical tool for studying complex networks in diverse applications of science and engineering, such as neural networks in the brain, biochemical reaction networks in cells, communication networks, such as the internet, and social networks. Topics covered include set theory, defining a graph, as well as defining the degree of a node and the degree distribution of a graph.

Students gain a deeper understanding of how sound sensors work through a hands-on design challenge involving LEGO MINDSTORMS(TM) NXT taskbots and sound sensors. Student groups each program a robot computer to use to the sound of hand claps to control the robot's movement. They learn programming skills and logic design in parallel. They experience how robots can take sensor input and use it to make decisions to move and turn, similar to the human sense of hearing. A PowerPoint® presentation and pre/post quizzes are provided.

Host Harry Kreisler welcomes neurobiologist Christof Koch for a discussion of what biology can tell us about consciousness. He discusses the framework for defining the problem which he developed with Nobel Laureate Francis Crick. He reflects on the ongoing revolution in our understanding of the brain and how technology is impacting the transformation of our neuronal correlates of consciousness. He also discusses the implications of his research for our understanding of manŐs place in the universe. (49 min)

Culture, Embodiment, and the Senses will provide an historical and cross-cultural analysis of the politics of sensory experience. The subject will address western philosophical debates about mind, brain, emotion, and the body and the historical value placed upon sight, reason, and rationality, versus smell, taste, and touch as acceptable modes of knowing and knowledge production. We will assess cultural traditions that challenge scientific interpretations of experience arising from western philosophical and physiological models. The class will examine how sensory experience lies beyond the realm of individual physiological or psychological responses and occurs within a culturally elaborated field of social relations. Finally, we will debate how discourse about the senses is a product of particular modes of knowledge production that are themselves contested fields of power relations.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Much research on epilepsy treatment has focused on properly identifying the epileptogenic zone, the area of the brain where a seizure initiates. This zone, previous studies have found, can potentially be recognized by high-frequency activity, or “fast activity,” that occurs in a brain area right after seizure onset. However, this method does not accurately delineate the epileptogenic zone from other normal brain tissues. A new paper published in Human Brain Mapping examines how a different marker, or “fingerprint,” can be used to accurately identify the epileptogenic zone, whether this fingerprint can be seen in different types of brainwaves, and, finally, how the method compares to using fast activity. The study builds on a previous paper published by the authors, in which the fingerprint itself was identified as a specific pattern of brain activity observed in seizure patients..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This presentation provides an overview of the existing treatment available for treatment of obesity. Genetic studies have revealed that the genes contributing to development of obesity is mainly located in the brain, therefore it would be logical to tro to target the brain when pursuing drugs for the treatment of obesity. However it’s not that simple.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The physiological effects of melatonin are far reaching, from acting as an neuroprotective agent to regulating circadian rhythms and sleep cycles. An imbalance of this hormone has even been linked to neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and Huntington’s. The precise molecular mechanism by which melatonin exerts these effects, however, remains a mystery. To shed light on this process, a team of researchers has developed a melatonin-like compound that is unable to penetrate the cell membrane and binds only to cell-surface receptors. Melatonin’s physiological effects on the brain are controlled by the lock-and-key-like properties of this hormone and its receptors. When melatonin binds to its corresponding receptor, a biochemical signal is sent into the cell. But recent data suggests that this interaction may also occur inside the cell, itself. Specifically, on mitochondria within brain cells..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"When someone loses consciousness, one of the main things that happens is a loss of integrated activity across functionally separate brain networks. But there isn’t a single way of measuring this that tracks with the degree of consciousness. That could soon change given the findings of a new article in the journal Anesthesiology. A group of international researchers examined functional magnetic resonance imaging, or fMRI, data and found support for the use of something called the “global brain signal”. The global signal is an average of all gray-matter brain activity across each voxel in a scan, and reflects global coordination at a given time. When there’s high coordination, voxels will all be mostly positive -- or negative -- and the sum will be positive or negative. In contrast, if there’s less coordination, the voxels across the brain won’t match and the values will cancel out..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Students' understanding of how robotic ultrasonic sensors work is reinforced in a design challenge involving LEGO MINDSTORMS(TM) NXT robots and ultrasonic sensors. Student groups program their robots to move freely without bumping into obstacles (toy LEGO people). They practice and learn programming skills and logic design in parallel. They see how robots take input from ultrasonic sensors and use it to make decisions to move, resulting in behavior similar to the human sense of sight but through the use of sound sensors, more like echolocation. Students design-test-redesign-retest to achieve successful programs. A PowerPoint® presentation and pre/post quizzes are provided.

This class is a multidisciplinary introduction to pharmacology, neurotransmitters, drug mechanisms, and brain diseases from addiction to schizophrenia.
From Abilify® to Zyrtec®, the world is full of fascinating drugs. If you are poisoned by sarin nerve gas, you may be able to save your life by huffing some BZ nerve gas. This class will explain that chemical curiosity, along with a host of other interesting tidbits of pharmacology. The structure of the class interleaves basic concepts with specific examples and entertaining tangents, so it is not loaded with boring abstract theory. In the first class you will learn what a neurotransmitter is, and you will immediately apply that knowledge when we discuss the mechanism of caffeine. The class is highly multidisciplinary, including topics such as patent law, medical ethics, history, and the physics of crack pipes.

This class is a multidisciplinary introduction to pharmacology, neurotransmitters, drug mechanisms, and brain diseases from addiction to schizophrenia.
From Abilify® to Zyrtec®, the world is full of fascinating drugs. If you are poisoned by sarin nerve gas, you may be able to save your life by huffing some BZ nerve gas. This class will explain that chemical curiosity, along with a host of other interesting tidbits of pharmacology. The structure of the class interleaves basic concepts with specific examples and entertaining tangents, so it is not loaded with boring abstract theory. In the first class you will learn what a neurotransmitter is, and you will immediately apply that knowledge when we discuss the mechanism of caffeine. The class is highly multidisciplinary, including topics such as patent law, medical ethics, history, and the physics of crack pipes.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Parkinson's disease is a neurodegenerative disease that affects more than 10 million people across the globe. Despite improvements in treating the disease, doctors still have many unanswered questions, including when to start treatment. Now, researchers at the University of Rochester have taken another look at a past clinical trial to begin to answer that key question. Parkinson's occurs when neurons in a part of the brain called the substantia nigra die off. These neurons produce the neurotransmitter dopamine, and with the loss of those neurons, patients develop tremors, have difficulty moving, and show slow movement, among other symptoms. Restoring the dopamine with L-dopa or boosting levels with a dopamine agonist can help. Some studies have suggested that early dopaminergic treatment could protect neurons and slow disease progression. But that evidence isn't yet convincing, and the drugs might also cause uncontrolled, involuntary movements, leaving this an open question in the field..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"We already know that eating good food makes our bodies feel good, but what we eat can also affect our brains. Microbiota that reside in our guts influence behavior through a mechanism called the microbiota-gut-brain axis. Certain foods – including prebiotic, probiotic, and fermented foods – have received attention for their mood-boosting benefits. Now, a new study adds another food to that list. Kefir, a fermented food produced from a combination of live bacteria and yeasts, is known to affect the gut microbiota, but whether it affects the microbiota-brain axis and behavior is unclear. Researchers fed mice two different types of kefir and examined their behavior and their gut microbes. They found that feeding kefir reduced stress-induced hormone signaling and reward-seeking and repetitive behaviors in the mice. Different kefirs affected different types of behaviors and changed the abundance of specific bacterial species in the gut..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Estrogen receptor α, or ERα, is believed to play a central role in controlling inflammation. Research suggests that ERα does that by regulating anti-inflammatory signaling in the microglia, the only immune cells that reside in the brain. Now, a new study confirms ERα’s beneficial role in the brains of mice. The work explored one mechanism believed to prime ERα to fight inflammation, the attachment of a phosphoryl group to a specific amino acid in ERα’s structure -- a process known as “phosphorylation”. To test that mechanism, researchers blocked the phosphorylation of ERα in microglia from mice. That absence, it turned out, compromised the cells’ defenses against inflammation – leaving mice vulnerable to negative effects. For example, some mice with blocked ERα phosphorylation were obese and showed weakened motor skills. Further study could help explain how phosphorylated ERα regulates brain immunity and inflammation in brain diseases..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.