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Drug shows the potential for long-term relief from a type of chronic leukemia
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Researchers from The University of Texas MD Anderson Cancer Center have good news for patients with myelofibrosis, a serious cancer that causes blood cells to grow uncontrollably, leading to severe scarring in bone marrow. In concluding a clinical trial started in 2009, they’ve found a safe and effective long-term treatment option for patients with the disease. Overall, the trial results showed that treatment with ruxolitinib not only reduced some of the more severe symptoms of myelofibrosis but also significantly improved survival. The trial, called COMFORT-I, took place at 89 sites across Australia, Canada, and the USA and looked at about 300 patients with the worst types of myelofibrosis. Because the disease interferes with blood cell production, these patients experience symptoms such as severe weakness and fatigue, anemia and spleen enlargement. They also have shortened survival. In the trial, the patients were randomized to receive either ruxolitinib or a placebo..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
03/22/2021
Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Traumatic brain injury (TBI) is a leading cause of fatality and disability worldwide. Despite immense clinical efforts, treatments for TBI remain limited, and better understanding is needed. While most treatments have targeted neuronal cells, another cell type may also have an important role in TBI. Astrocytes, a subtype of brain-resident glial cells, help to control blood flow and maintain homeostasis in the central nervous system. These important cells have dual roles after TBI which must be better understood to improve treatment. During TBI, mechanical damage to neurons and blood vessels occurs instantly. This is followed by pathological processes - neuroinflammation and cell stress - mediated by astrocytes, among others. The astrocyte response is initiated to protect the central nervous system and promote wound healing but may become maladaptive over time as astrocytes can play bidirectional roles in plasticity and reconstruction after TBI..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
06/23/2020
Duccio's Madonna and Child
Conditional Remix & Share Permitted
CC BY-NC-SA
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This art history video discussion examines Duccio di Buoninsegna, Madonna and Child, tempera and gold on panel, c. 1300 (Metropolitan Museum of Art).

Subject:
Art History
Arts and Humanities
Material Type:
Diagram/Illustration
Lecture
Provider:
Khan Academy
Provider Set:
Smarthistory
Author:
Beth Harris
David Drogin
Date Added:
11/16/2012
Duchamp's Fountain
Conditional Remix & Share Permitted
CC BY-NC-SA
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This art history video discussion looks at Marcel Duchamp's "Fountain" (1917/1964). Porcelain urinal, paint (San Francisco Museum of Modern Art).

Subject:
Art History
Arts and Humanities
Material Type:
Diagram/Illustration
Lecture
Provider:
Khan Academy
Provider Set:
Smarthistory
Author:
Beth Harris
Steven Zucker
Date Added:
12/19/2012
Dunia fi Lubnan: An Online Arabic Interactive Storybook
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CC BY-NC-ND
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“Dunia Fi Lubnan” is an online Arabic interactive storybook developed by Alefb multicultural center for children with support from Qatar Foundation International through a Curriculum Development grant.

The storybook is a fully illustrated interactive story, and includes interactive comprehension quiz questions prompted by "Nahla the bee" in English, playful drills to test reading, writing and comprehension, and cultural games from which the learner can accumulate points to earn a surprise gift from Alefb. The story of Dunia, stretched out over 22 fully illustrated pages, tells a tale about a young girl who tries to overcome her fear of speaking Arabic. Along the way, users are exposed to several interactive self-correcting drills, audio files, cultural authentic documents tackling a wide variety of learning topics based on the themes and lessons within Dunia's story. Animations, sounds, glossaries pages and English translation tools all provide helpful hints and aid the learner in staying engaged. “Dunia Fi Lubnan” is an integrated educational material in that it uses both Modern Standard Arabic, الفصحى and colloquial العامية.

The interactive and multimedia components are designed in part to enhance regular curricula for teaching Arabic as a foreign language to children, teens and even adults, individually or in a classroom setting.

When all of the modules are completed, learners will have acquired new vocabulary, reinforced their reading, writing and comprehension skills, and been exposed to different practices, products and perspectives of the Arabic culture. Learners will be able to write a simple postcard using vocabulary from the following topics: Greetings, Feelings, Activities, Countries and Places, Colors, Food, Things and Family/Friends.

Subject:
Arts and Humanities
Material Type:
Activity/Lab
Assessment
Diagram/Illustration
Homework/Assignment
Interactive
Date Added:
07/13/2014
Duodenum - Anatomy & Physiology
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CC BY-NC-ND
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The duodenum is the proximal part of the small intestine and extends from the pylorus of the stomach to the jejunum. It has descending and ascending portions and both portions have digestive and absorptive functions.

Subject:
Anatomy/Physiology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Anatomy & Physiology
Date Added:
02/05/2015
Durer's Prints
Conditional Remix & Share Permitted
CC BY-NC-SA
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This art history video discussion examines Albrecht Dürer's prints: "Four Horsemen of the Apocalypse" (ca. 1497–98) and "St. Jerome in his Study" (1514).

Subject:
Art History
Arts and Humanities
Material Type:
Diagram/Illustration
Lecture
Provider:
Khan Academy
Provider Set:
Smarthistory
Author:
Beth Harris
David Drogin
Date Added:
11/16/2012
Durer's Self-portrait (1498)
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CC BY-NC-SA
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This art history video discussion examines Albrecht Dürer's "Self-portrait", 1498, oil on panel, 52 x 41 cm (Museo Nacional del Prado, Madrid).

Subject:
Art History
Arts and Humanities
Material Type:
Diagram/Illustration
Lecture
Provider:
Khan Academy
Provider Set:
Smarthistory
Author:
Beth Harris
Steven Zucker
Date Added:
11/16/2012
Durer's The Large Piece of Turf
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CC BY-NC-SA
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This art history video discussion examines Albrecht Durer's "The Large Piece of Turf", 1503, watercolor and gouache on paper, 16-1/8 x 12-5/8 inches / 41 x 32 cm (Graphische Sammlung Albertina, Vienna)

Subject:
Art History
Arts and Humanities
Material Type:
Diagram/Illustration
Lecture
Provider:
Khan Academy
Provider Set:
Smarthistory
Author:
Beth Harris
Steven Zucker
Date Added:
11/16/2012
Dust Bowl Migration
Unrestricted Use
Public Domain
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A selection of Library of Congress primary sources exploring the The Great Depression and World War II (1929-1945). This set also includes a Teacher's Guide with historical context and teaching suggestions.

Subject:
History
U.S. History
Material Type:
Diagram/Illustration
Primary Source
Provider:
Library of Congress
Provider Set:
Primary Source Set
Date Added:
04/25/2006
Dust Bowl Migration
Read the Fine Print
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In 1931, a severe drought hit the Southern and Midwestern plains. As crops died and winds picked up, dust storms began. As the "Dust Bowl" photograph shows, crops literally blew away in "black blizzards" as years of poor farming practices and over-cultivation combined with the lack of rain. By 1934, 75% of the United States was severely affected by this terrible drought.The one-two punch of economic depression and bad weather put many farmers out of business. In the early 1930s, thousands of Dust Bowl refugees ? mainly from Oklahoma, Texas, Colorado, Kansas, and New Mexico ? packed up their families and migrated west, hoping to find work. Entire families migrated together (such as the men shown in "Three generations of Texans now Drought Refugees") in search of a better life. Images such as "Midcontinent ? Family Standing on the Road with Car," "Drought Refugees," and "Untitled, ca. 1935 (Worn-Down Family in Front of Tent)" offer a glimpse into their experience on the road, and show that cars provided many families both transportation and shelter on the road. About 200,000 of the migrants headed for California. The state needed to figure out how to absorb the thousands of destitute people crossing its borders daily. One of their tactics was to document the plight of the refugees. In 1935, photographer Dorothea Lange joined the Rural Rehabilitation Division of the California State Emergency Relief Administration (SERA), a section of the Federal Emergency Relief Administration. She was assigned the job of using her camera to document the growing number of homeless Dust Bowl refugees migrating to California. She worked with Paul S. Taylor, a professor at the University of California, Berkeley, who was researching conditions of rural poverty in order to make recommendations on how to improve the workers' conditions. The work by Taylor and Lange played an important role in helping to raise public awareness of the crisis. The reports they made for the government included both data and striking images that revealed the desperate conditions in which the migrants lived and confirmed the need for government intervention. Stark images such as "Home of Oklahoma Drought Refugees" resonated with the public, and portraits of drought refugees like "Ruby from Arkansas" and others shown in this topic humanized the migrants for more fortunate citizens. In March 1936, Lange took what became one of her most famous images, "Migrant Mother." This image of a 32-year-old woman became an icon for the suffering of ordinary people during Great Depression.

Subject:
Arts and Humanities
Material Type:
Diagram/Illustration
Lesson Plan
Primary Source
Reading
Teaching/Learning Strategy
Provider:
University of California
Provider Set:
Calisphere - California Digital Library
Date Added:
04/25/2013
Dye Your Own Socks!
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CC BY-NC
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Let's dye your own socks!!Using acid dyes to design your socks, learning the principle of three primary colors through this event, also to develop creativity. 

Subject:
Chemistry
Elementary Education
Visual Arts
Material Type:
Activity/Lab
Diagram/Illustration
Game
Interactive
Lesson
Lesson Plan
Author:
textileandclothing FJU
Date Added:
12/12/2022
Dysfunction of the cervical and vaginal epithelium can be induced by G. vaginalis infection
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Microbe-host epithelial cell interactions can promote or diminish the health of an epithelial barrier. The microbes and cells of the cervix and vagina are no exception. For example, high levels of Gardnerella vaginalis can lead to bacterial vaginosis, STDs, and preterm birth, while the presence of Lactobacillus species is usually associated with a healthy reproductive system. The host-microbiome interactions affecting cervicovaginal (CV) epithelial function were studied using CV epithelial cells mixed with G. vaginalis or Lactobacillus crispatus. G. vaginalis, but not L. crispatus, increased CV epithelial cell death. and G. vaginalis mediated an immune response in CV cells, partially through TLR2-dependent signaling pathways. In human CV fluid, cytokine immune profiling showed distinctive clustering of cytokines by Gardnerella spp. abundance and birth outcome..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/14/2023
The E3 ligase TRIM15 promotes NSCLC progression via the Keap1–Nrf2 signaling pathway
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Non-small cell lung cancer (NSCLC) is the deadliest cancer worldwide, killing more than 80% of patients within five years of diagnosis. Aberrant TRIM protein expression is known to play an important role in NSCLC, but the mechanisms aren’t clear. To learn more, a recent study investigated TRIM15 dysregulation in NSCLC. In a tissue microarray, TRIM15 was upregulated in NSCLC versus control tissues, and high TRIM15 expression was associated with a poor prognosis. In vitro, TRIM15 knockdown in NSCLC cells decreased cell proliferation, migration, and invasion, while TRIM15 overexpression exerted the opposite effects, which were dependent on the RING domain with E3 ubiquitin ligase activity. Similar results of TRIM15 silencing and overexpression were obtained in vivo in a subcutaneous xenograft mouse model. Mechanistic experiments revealed that TRIM15 ubiquitinated Keap1, targeting it for degradation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/18/2022
ECG Heart Rate
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CC BY-NC-ND
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Workplace English for the Canadian medical laboratory. Learn how to calculate your patient's heart rate by counting large squares on an electrocardiogram. .P...

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Activity/Lab
Assessment
Case Study
Diagram/Illustration
Homework/Assignment
Lesson
Simulation
Author:
Theresa McCuaig
Date Added:
01/20/2021
ECONS XI
Unrestricted Use
CC BY
Rating
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This is an Economics Grade 11 Course.Content that is taught includes the following:Lesson 1 on different kinds of marketsLesson 2 on Perfect Competition market structureLesson 3 on Monopoly market structureLesson 4 on Monopolistic Competition market structureLesson 5 on Oligopoly market structure

Subject:
Economics
Material Type:
Activity/Lab
Assessment
Diagram/Illustration
Full Course
Homework/Assignment
Lesson
Reading
Simulation
Author:
Hlengiwe SENOSI
Date Added:
06/26/2021
E-E-E-Yah-Yip Go Over with U.S. Marines.
Unrestricted Use
Public Domain
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Poster showing a marine cheering as he raises his rifle and bayonet. Apply at: 530 Willis Ave., Bronx, N.Y. Artist monogram is illegible. Forms part of: Willard and Dorothy Straight Collection.

Subject:
History
U.S. History
Material Type:
Diagram/Illustration
Primary Source
Provider:
Library of Congress
Provider Set:
Library of Congress - World War I Posters
Date Added:
06/18/2013
E-E-E-Yah-Yip Go Over with U.S. Marines.
Unrestricted Use
Public Domain
Rating
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Poster showing a marine cheering as he raises his rifle and bayonet. Banners pasted over original text: Now open for enlistment. 24 East 23rd Street, New York.

Subject:
History
U.S. History
Material Type:
Diagram/Illustration
Primary Source
Provider:
Library of Congress
Provider Set:
Library of Congress - World War I Posters
Date Added:
06/18/2013