This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"G protein-coupled receptor (GPCR) signaling plays an important role in regulating cellular responses to external stimuli. GPCRs are so critical that they are a common pharmaceutical target, with 35% of available drugs targeting the receptors. But despite their importance, the mechanism underlying G protein selectivity for closely related Gαi proteins is unclear. In a recent study, researchers followed up on their previous finding that Gαi protein subunits prefer different lipid domains in the membrane. Using live-cell fluorescence microscopy techniques, they characterized the diffusion of Gαi subunits and the dopamine D2 long receptor isoform (D2R). They found that although Gαi protein subunits are very similar, the Gαi2 subunit displayed faster lateral diffusion than Gαi1. Distinct Gαi heterotrimers localized to different areas of the cell membrane, correlating with the efficiency of D2R-mediated inhibition of cAMP..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"In many cell types, growth factor stimulation triggers the formation of structures called circular dorsal ruffles (CDRs). CDRs are large, rounded ruffles on the upper cell membrane that serve as platforms for PI3K–PIP3–AKT protein signaling and probably play a role in cell growth. CDRs are present in some types of cancer cells, but it’s unclear whether they contribute to cancer development. To find out, researchers recently treated six cancer cell lines and one normal cell line with two growth factors: epidermal growth factor and insulin. Both growth factors induced CDR formation in the Hep3B hepatocellular carcinoma line, but not in normal liver cells, other hepatocellular carcinoma cells, breast cancer cells, or pancreatic cancer cells. Closer analysis confirmed that growth factor receptor proteins were recruited to the CDRs and that the PI3K–PIP3–AKT pathway was activated at the ruffles..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
Cells Grade Level: 10th-12thSubject: ALS AnimalsDuration: 100 minutesDOK Level: 3SAMR Level: RedefinitionIndiana Standard: ALSA-2.10 Compare and contrast animal, plant, and bacterial cells at the biological and chemical levels.Objective: Students will be able to compare and contrast animal, plant, and bacterial cells with 95% accuracy.Essential Question: What are the shared components of cellsProcedure: Ask the students what is the basis of all life?Show them the video Cells Cells - Parts of the Cell RapHand out the plant and animal cell worksheets through google classroomHave the students use the following animation CELLS alive! Interactive Animal and Plant Cells to fill out the worksheetsGroup student into pairsExplain that they will be creating a model that compares plant and animal cellsHandout the Cell Model Sheet through google classroomHave the students create a brainstorming sheetProvide one class period for the students to build and fill out the cell model sheet based on their modelsHave the students complete the memory activity Product or Assessment: The students will be assessed on the cell model sheet Credits:Cells Alive Website, http://www.cellsalive.com/cells/cell_model.htm
In this unit, students look at the components of cells and their …
In this unit, students look at the components of cells and their functions and discover the controversy behind stem cell research. The first lesson focuses on the difference between prokaryotic and eukaryotic cells. In the second lesson, students learn about the basics of cellular respiration. They also learn about the application of cellular respiration to engineering and bioremediation. The third lesson continues students' education on cells in the human body and how (and why) engineers are involved in the research of stem cell behavior.
This is an inquiry activity that uses either pictures of cells or …
This is an inquiry activity that uses either pictures of cells or microscopes and slides to get students thinking about cell structure and function. You could look at prokaryotic vs eukaryotic cells, plant vs animal or different types of cells found in one organism. The objective is to have students begin to make the connection between sructure and function in cells.
This textbook was written for collegiate Cell and Molecular Biology courses and …
This textbook was written for collegiate Cell and Molecular Biology courses and may be appropriate at both an introductory level and also as a resource for more advanced courses.
Yeast can reproduce sexually through a signaling pathway known as the mating …
Yeast can reproduce sexually through a signaling pathway known as the mating factor pathway. In this process, two haploid yeast cells combine to form a diploid cell. Yeast cells secrete a signal molecule called mating factor that attracts them to their mates. Once the mating factor of one yeast binds to the receptor on another yeast, an outgrowth called a "shmoo" forms, which allows the yeast cells to fuse together.
In this course we will explore how altered metabolism drives cancer progression. …
In this course we will explore how altered metabolism drives cancer progression. Students will learn (1) how to read, discuss, and critically evaluate scientific findings in the primary research literature, (2) how scientists experimentally approach fundamental issues in biology and medicine, (3) how recent findings have challenged the traditional “textbook” understanding of metabolism and given us new insight into cancer, and (4) how a local pharmaceutical company is developing therapeutics to target cancer metabolism in an effort to revolutionize cancer therapy.
This course serves as an introduction to the structure and function of …
This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.
This course includes: Surveying the molecular and cellular mechanisms of neuronal communication. …
This course includes:
Surveying the molecular and cellular mechanisms of neuronal communication. Coversion channels in excitable membrane, synaptic transmission, and synaptic plasticity. Correlation of the properties of ion channels and synaptic transmission with their physiological function such as learning and memory. Discussion of the organizational principles for the formation of functional neural networks at synaptic and cellular levels.
You know ‘em, you love ‘em. They’re the powerhouse of the cell: …
You know ‘em, you love ‘em. They’re the powerhouse of the cell: mitochondria. They produce the ATP molecules that we use to do everything from talk to our friends to run a marathon. In this episode of Crash Course Biology, we’re taking a deep dive into cellular respiration, the process that produces the ATP inside of our mitochondria.
Chapters: Getting Energy Mitochondria & ATP Cellular Respiration Glycolysis The Citric Acid Cycle The Electron Transport Chain Review & Credits Credits
Summary Diagram of the four major stages of cellular respiration. Attributions: Figure modified …
Summary Diagram of the four major stages of cellular respiration. Attributions: Figure modified from OpenStax, Carbohydrate Metabolism. OpenStax CNX. Jan 5, 2015 http://cnx.org/contents/9d68abf9-4c2e-4ef7-88d1-c963c5c844b9@4. NADH and FADH2 images modified from BQmUB2012173 [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)].
In this lesson, students learn about the basics of cellular respiration. They …
In this lesson, students learn about the basics of cellular respiration. They also learn about the application of cellular respiration to engineering and bioremediation. And, students are introduced to the process of bioremediation and several examples of how bioremediation is used during the cleanup of environmental contaminants.
This course reviews the processing and structure of cellular materials as they …
This course reviews the processing and structure of cellular materials as they are created from polymers, metals, ceramics, glasses, and composites, develops models for the mechanical behavior of cellular solids, and shows how the unique properties of honeycombs and foams are exploited in applications such as lightweight structural panels, energy absorption devices and thermal insulation. The applications of cellular solids in medicine include increased fracture risk due to trabecular bone loss in patients with osteoporosis, the development of metal foam coatings for orthopaedic implants, and designing porous scaffolds for tissue engineering that mimic the extracellular matrix. Modelling of cellular materials applied to natural materials and biomimicking is explored. Students taking the graduate version of the class are required to complete additional assignments.
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