This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"These tiny sacs within cells are called multivesicular bodies, or MVBs. Once considered nothing more than a part of the cell’s waste disposal and recycling system, MVBs are now understood to play multiple important roles, including promoting tumor progression. MVBs selectively load substances such as lipids, proteins, and nucleic acids, and then fuse with the cell membrane to release their payloads outside the cell in the form of exosomes. In tumors, the key proteins involved in MVB formation, transport, and fusion are abnormally expressed, and evidence suggests that MVBs promote virtually all aspects of cancer progression – from tumor expansion to drug resistance. For example, MVBs direct the cellular degradation needed for cancer cells to form the finger-like projections that help them spread to other organs, and studies show that MVB cargoes can transfer cancer drug resistance from one cell to another..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Alzheimer’s disease is the sixth leading cause of death and one of the most prevalent forms of dementia, affecting over 50 million people worldwide. Unfortunately, the molecular signaling pathways underlying neurodegeneration in Alzheimer’s disease are not clearly understood. A recent study identified a link between two physiological phenomena that are affected in Alzheimer's disease: disrupted calcium signaling, which is associated with memory loss and cognitive dysfunction; and increased iron accumulation, which results in neurotoxicity in the brain. Using genetically modified human cell lines and mice, the researchers studied the mechanistic connections between calcium signaling and iron transport. They found that calcium (Ca²⁺) signaling through CAMKK2 and CAMK4 proteins had direct effects on transferrin protein-mediated iron transport..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Coursework examines important issues facing the youth of today and discusses sexual assault, sexual violence, sex trafficking, and the importance of advocating for self and for others. The coursework is inclusive to all genders/races/ethnicities/abilities and makes the point that sexual violence does not discriminate. This is meant to be an open, discussion-based seminar to ask important questions and learn about safety for yourself and others from sexual violence. Learn about your resources and your rights as an individual to help serve yourself and your community. Students will complete a community project that contributes to student volunteer hours. This is meant to help them immerse into the content they learn within the scope of this course, as well as foster empathy and civic engagement within students to become passionate and upstanding individuals for their communities.