This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"One of the hallmarks of cancer is the reprogramming of the body’s metabolism to support tumor growth. That includes the breakdown of glucose into lactate, a process that normally occurs only under low-oxygen conditions. High levels of lactate are known to boost tumor invasion and suppress attacks by the immune system, and a new study suggests that lactate might also make cancer cells increasingly resistant to chemotherapy drugs. Experiments showed that exposure to the chemotherapy drug etoposide reprogrammed non-small lung cancer cells to generate increasing amounts of lactate. The resulting buildup of lactic acid was identified as the key process conferring drug resistance through the upregulation of multidrug resistance-associated protein 1 (MRP1). MRP1 expression inhibits the toxic effects of chemotherapy drugs like etoposide by increasing their expulsion from cancer cells. Removing lactate with sodium bicarbonate was sufficient to overcome resistance to etoposide..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

StoryWorks develops inclusive and transformative educational theater experiences that provide students with the opportunity to examine our country’s civil rights history. Through content consistent with school curriculum standards, the program engages students in experiential learning and inspires them to ask deeper questions about the historical underpinnings behind contemporary issues. The process creates pathways to civic engagement, creates lasting memories and instills a tangible sense of social belonging. This StoryWorks educational project is built around Beautiful Agitators, a theatrical play about Vera Mae Pigee, a hair stylist and business owner in Clarksdale, Mississippi, and one of the unsung heroes of the civil rights era. Using her beauty parlor as a hub for Delta-based organizing and resistance, Pigee operated her salon by day and then transformed it into a clandestine center for civil rights organization and education in the evenings. Known for her big hats and larger than life personality, Mrs. Pigee led the direct action that registered nearly 6,000 African Americans to vote in the region. Although Pigee was largely left out of the history books, along with many women of the movement, our play Beautiful Agitators and accompanying curriculum revives her legacy, highlighting her methods and tactics. Inspired by the innovative K-12 civil rights education standards developed by the Mississippi Civil Rights Commission. Our commitment is to expand upon the standards by further developing content related to social justice, power relations, environmental justice, diversity, equity, mutual respect, and civic engagement. Beautiful Agitators combines inquiry with higher-order thinking skills of analysis, evaluation and synthesis. Set in a beauty parlor owned and operated by a Black woman in the Mississippi Delta, our curriculum is based on our investigation into primary sources and their relationship to critical moments in the national movement. This foundation of historical context allows for students and educators to find contemporary parallels which further engage learners to reflect upon the legacy of the civil rights movement and the struggles that we, as citizens, continue to grapple with today.View the complete play Beautiful Agitators on the StoryWorks Theater site.Implementation1. Beautiful Agitators Performance Classroom watches a prerecorded, staged reading of the play Beautiful Agitators, which was created and performed by artists from the Mississippi Delta, home of Vera Mae Pigee.2. Lesson Plan Activities Following the eight-lesson plan structure, students will read aloud or act out scenes from the play. This participatory interaction with the text and the historical events promotes a high level of engagement from the students and encourages experiential learning. These activities directly correspond to scenes in the play and to specific content area standards. Teacher leads guided discussions and helps to explain the historical context and theme of each scene. Students/actors have the opportunity to share their experiences having portrayed these historical figures. 

Through the play Beautiful Agitators and accompanying curriculum, students will eplore the life of Vera Mae Pigee and the importance of coalition building to achieve civil rights.