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Animal Behavior
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The introductory topics will cover various approaches to the study of animals and their behavior. Key concepts in studies of animal behavior, emphasizing ethology, are covered in class and in the assigned readings from Scott (2005), supplemented by selections from other books, especially from classics in the field as well as selected videos. Next, key concepts in sociobiology are covered using readings from Alcock (2001), supplemented by selections from additional books and some video presentations.

Subject:
Biology
Life Science
Material Type:
Full Course
Provider Set:
MIT OpenCourseWare
Author:
Schneider, Gerald
Date Added:
09/01/2013
Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor
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Accumulating evidence indicates high risk of bias in preclinical animal research, questioning the scientific validity and reproducibility of published research findings. Systematic reviews found low rates of reporting of measures against risks of bias in the published literature (e.g., randomization, blinding, sample size calculation) and a correlation between low reporting rates and inflated treatment effects. That most animal research undergoes peer review or ethical review would offer the possibility to detect risks of bias at an earlier stage, before the research has been conducted. For example, in Switzerland, animal experiments are licensed based on a detailed description of the study protocol and a harm–benefit analysis. We therefore screened applications for animal experiments submitted to Swiss authorities (n = 1,277) for the rates at which the use of seven basic measures against bias (allocation concealment, blinding, randomization, sample size calculation, inclusion/exclusion criteria, primary outcome variable, and statistical analysis plan) were described and compared them with the reporting rates of the same measures in a representative sub-sample of publications (n = 50) resulting from studies described in these applications. Measures against bias were described at very low rates, ranging on average from 2.4% for statistical analysis plan to 19% for primary outcome variable in applications for animal experiments, and from 0.0% for sample size calculation to 34% for statistical analysis plan in publications from these experiments. Calculating an internal validity score (IVS) based on the proportion of the seven measures against bias, we found a weak positive correlation between the IVS of applications and that of publications (Spearman’s rho = 0.34, p = 0.014), indicating that the rates of description of these measures in applications partly predict their rates of reporting in publications. These results indicate that the authorities licensing animal experiments are lacking important information about experimental conduct that determines the scientific validity of the findings, which may be critical for the weight attributed to the benefit of the research in the harm–benefit analysis. Similar to manuscripts getting accepted for publication despite poor reporting of measures against bias, applications for animal experiments may often be approved based on implicit confidence rather than explicit evidence of scientific rigor. Our findings shed serious doubt on the current authorization procedure for animal experiments, as well as the peer-review process for scientific publications, which in the long run may undermine the credibility of research. Developing existing authorization procedures that are already in place in many countries towards a preregistration system for animal research is one promising way to reform the system. This would not only benefit the scientific validity of findings from animal experiments but also help to avoid unnecessary harm to animals for inconclusive research.

Subject:
Biology
Life Science
Material Type:
Reading
Provider:
PLOS Biology
Author:
Christina Nathues
Hanno Würbel
Lucile Vogt
Thomas S. Reichlin
Date Added:
08/07/2020
Fossil Halls
Read the Fine Print
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The American Museum of Natural History is home to the world's largest collection of vertebrate fossils, totaling nearly one million specimens. This Web site offers visitors a virtual visit to the Museum's famed Fossil Halls. It features seven sections along with a brief introduction, a Teacher's Guide, and information about the Museum's Division of Paleontology.

Subject:
Archaeology
Social Science
Material Type:
Lecture
Reading
Provider:
American Museum of Natural History
Provider Set:
American Museum of Natural History
Date Added:
02/16/2011
Indiana Mammals and Their Environments
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CC BY-NC-ND
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This is a project-based learning lesson about Indiana Mammals and Their Environments. The lesson is about common Indiana animals that the kids see everyday and how humans impact their environments. The goal of the lesson is for the kids to create an environment that meets the needs of all of the animals and the humans without causing any problems, and then present those environments to the class in the form of a claymation project.

Subject:
Life Science
Material Type:
Activity/Lab
Data Set
Interactive
Lesson
Lesson Plan
Date Added:
02/28/2017
Neural Plasticity in Learning and Development
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Roles of neural plasticity in learning and memory and in development of invertebrates and mammals. An in-depth critical analysis of current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Discussion of original papers supplemented by introductory lectures.

Subject:
Biology
Life Science
Material Type:
Full Course
Provider Set:
MIT OpenCourseWare
Author:
Liu, Guosong
Miller, Earl
Quinn, William
Tonegawa, Susumu
Wilson, Matt
Date Added:
02/01/2002