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Uncovering how low-molecular-weight carrageenan triggers an immune response
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Low-molecular-weight carrageenan (Cg) is a seaweed-derived sulfated polysaccharide that has been widely used to stimulate inflammation in preclinical studies. However, exactly how Cg induces inflammation is still unclear. Using cell culture and mouse model experiments, investigators examined the molecular basis of two inflammatory processes triggered by Cg: macrophage activation and cytokine production. Mouse peritoneal macrophage primary cell cultures were stimulated with a form of Cg, κ-Cg. The researchers found that κ-Cg activates peritoneal macrophages to produce pro-inflammatory cytokines such as TNF and IL-1β. While κ-Cg-induced TNF production and secretion depend on TLR4/MyD88 signaling, the production of pro-IL-1β relies on the TLR4/TRIF/SYK/ reactive oxygen species signaling pathway..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
11/11/2020