This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Alpha-1 antitrypsin deficiency (AATD)-mediated liver disease is a form of toxic inflammation associated with the retention of mutant alpha-1 antitrypsin within cells. Patients with this disease typically show fibrosis and cirrhosis of the liver. Unfortunately, the mechanism of AATD-mediated liver disease is not well understood. To gain some insight, researchers recently explored the role of extracellular vesicles in the progression of AATD-mediated liver disease. They isolated vesicles from the plasma of individuals with both AATD and liver disease and compared them with vesicles from healthy individuals in terms of cytokine and chemokine expression as well as miRNA expression. Vesicles from individuals with AATD were shown to activate hepatic stellate cells in vitro, which is believed to be one of the first steps of fibrosis. a process mediated by the NF-κB and JAK/STAT signaling pathways..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 11/12/2020
