This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Exosomes are tiny membrane-bound vesicles that could be cutting-edge tools for cancer diagnosis and treatment. Exosomes are released by nearly every cell type to transport biomolecule cargo between cells and can be found in most body fluids. Among exosome cargos, microRNAs have draw significant attention for their role in the development of various diseases. MicroRNAs are small non-coding RNA molecules that can regulate the expression of protein-encoding genes. Exosomal microRNAs have shown promise as diagnostic biomarkers and as therapeutic targets or even therapeutics themselves. Studies have suggested that the microRNAs in cancer cell exosomes resemble the microRNA pool from their parent cancer cell. Exosomal microRNAs may be of particular use for the detection and treatment of hematologic neoplasms, which include cancers like lymphoma and multiple myeloma. However, there are several barriers than need to be addressed before exosomal microRNAs can be used in clinical settings..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This is a lesson in which students use prior scientific knowledge as well as 21st century skills to create a short video explaining the school's healthy eating policy as well as its scientific underpinnings.  It is designed as a method of group assessment at the end of the topic of food science.

The Online Macromolecular Museum (OMM) is a site for the display and study of macromolecules. Macromolecular structures, as discovered by crystallographic or NMR methods, are scientific objects in much the same sense as fossil bones or dried specimens: they can be archived, studied, and displayed in aesthetically pleasing, educational exhibits. Hence, a museum seems an appropriate designation for the collection of displays that we are assembling. The OMM's exhibits are interactive tutorials on individual molecules in which hypertextual explanations of important biochemical features are linked to illustrative renderings of the molecule at hand.

Why devote a site to detailed visualizations of different macromolecules? In learning about the intricacies of life processes at the molecular level, it is important to understand how natural selection has fashioned the structure and chemistry of macromolecular machines to suit them for particular functions. This understanding is greatly facilitated by the visualization of 3-dimensional structure, when known. So, if static views of molecules (even in stereo) are worth a thousand words, then interactive animations of molecules should be worth much more. Indeed, we have found the types of displays represented here invaluable in gaining an appreciation for the details of key biochemical processes.

As Carl Brandon and John Tooze stated in their classic text, Introduction to Protein Structure:
"Molecular biology began some 40 years ago with the realization that structure was crucial for a proper understanding of function. Paradoxically, the dazzling achievements of molecular genetics and biochemistry led to the eclipse of structural studies. We believe the wheel has now come full circle, and those very achievements have increased the need for structural analysis at the same time that they have provided the means for it."

It is our opinion that structural analysis should extend into the classroom: as students learn about cellular mechanisms it is important that they study the chemistry of the molecular machines involved. These considerations have motivated the construction of the OMM.

The OMM is part of a collaborative effort by faculty and students interested in macromolecular structure-function relationships. The primary authors of some tutorials are students of David Marcey and he serves as author, co-author and site editor, and assumes all responsibility for content. Any criticisms, suggestions, comments, or questions should be sent to him at: marcey@callutheran.edu. All tutorials are copyrighted.

The OMM was started in 1996 for a Molecular Biology class at Kenyon College, where DM was a professor in the Biology Department (1990-1999). The OMM is now developed and housed at California Lutheran University, where DM has been a professor since 1999.

All cells, organs and tissues of a living organism are built of molecules. Some of them are small, made from only a few atoms. There is, however, a special class of molecules that make up and play critical roles in living cells. These molecules can consist of many thousands to millions of atoms. They are referred to as macromolecules (or large biomolecules).

Anchoring Phenomenon: A baby is born and seems perfectly healthy, but after a few days starts to exhibit strange symptoms that could lead to physical impairment or even death. What is causing the problem? Can the baby be saved? Unit Essential Question: How and why do cells make the molecules they need and get rid of the molecules they don’t need? What happens if steps in this process aren’t working?