This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Our genome is a lot like a book. When cells need information critical to their function, they must physically crack the genome open to arrive at the right chapter, or gene sequence. Often, the relevance of details from chapter one isn’t clear until chapter ten. Similarly, non-coding sequences often control the expression of genes far away in linear genomic distance but relatively close in three-dimensional space. Now, a new method of probing these regions could help scientists gain more information from much less starting material—and, in the process, help us learn more about the book of life. The technique is called HiCAR, short for Hi-C on Accessible Regulatory DNA. HiCAR builds off the Hi-C method, which uses high-throughput sequencing to detect how different regions of genomic DNA interact with each other. Specifically, HiCAR targets the regions of chromatin that are open and accessible to proteins with information about gene regulation..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Anatomy/Physiology
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 01/31/2023
