Overview of how the Pennsylvania Common Core Standards for Mathematics are driving changes in classrooms and schools, and where resources can be found to support the implementation of those changes.

Pennsylvania Assessment Anchors and Eligible Content eBook to assist educators in preparing student for the Keystone Exams.

What To Do Before, During, & After Testing. Accommodations Guidelines produced by the Pennsylvania Department of Education.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"CCL2 is a small cell-signaling protein that recruits immune cells to sites of inflammation. CCR2 is CCL2’s receptor. Together, CCL2 and CCR2 create an inflammatory and immune-suppressive microenvironment, which promotes tumor growth and progression and induces resistance to anticancer drugs. A recent review highlights research on the therapeutic potential of targeting this so-called “CCL2-CCR axis”. Circulating levels of CCL2 are particularly elevated in individuals with obesity. Studies on men with prostate cancer suggest that inhibiting CCL2 signaling can significantly inhibit tumor growth and invasion. More work is needed to differentiate natural CCL2 levels in patients from tumor-derived CCL2 involved in the formation and spread of tumors, which could lead to new ways of attacking cancer and cancer resistance..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Breast cancer is the most commonly diagnosed form of cancer, and it is also one of the most deadly. People who take progesterone for hormone replacement therapy or contraceptive purposes may be particularly at risk. A new study showed that disruption of the intricate balance between two cell signaling cascades may be at least partly to blame. Progesterone is thought to trigger cellular responses by binding to either classic nuclear receptors or non- classic membrane receptors. Researchers showed that the genes CCM1-3 (which form the CCM signaling complex) mediate the crosstalk between the signaling pathways associated with these two receptor types. The signaling network involving progesterone, the CCM complex, and membrane and nuclear receptors relies on an intricate feedback system to maintain homeostasis, indicating that excess progesterone can throw it out of balance..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Gastrointestinal stromal tumors (GISTs) are the most common malignant tumors in a type of gut tissue called mesenchyme. They’re caused by mutations that activate receptor tyrosine kinase (RTK) enzymes, and treatment with RTK inhibitors is initially successful, but over half of patients develop resistance, indicating a need for better treatments. Researchers recently investigated whether the drug THZ1, an inhibitor of the protein CDK7 that’s effective in other cancers, could help. They first confirmed that CDK7, which helps regulate the cell life cycle and gene transcription, was overexpressed in high-risk human GISTs. They also found that CDK7 overexpression predicted a poor outcome. However, low-dose THZ1 exerted pronounced anticancer effects in GIST cells both in vitro and in a mouse model. THZ1 also synergized with the RTK inhibitor imatinib to increase its efficacy..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

The Council on Foreign Relation's (CFR) "Deforestation in the Amazon" InfoGuide provides a compelling look at the causes and consequences of deforestation in the Brazilian Amazon and is available online in English and Portuguese. CFR InfoGuides are a multimedia series to promote understanding of complex foreign policy issues.

THIS IMAGE HAS BEEN MADE ON CANVA APP EXPLAINING THE PRINCIPLE BEHIND CHERNOBYL DISASTER ITS EFFECT AND AFTERMATH

This illustration gives you the detailed information on classification of chromatographic methods. Chromatographic methods had 3 main types that is based on stationary, stationary phase format & mobile phase.

In this video we learn with an expert about climate change and its impact on agriculture. Vincent Chaplot is a researcher for L'OCEAN .

In this video we learn with an expert about the climate migration process. François Gemmene is a professor at Science-Po.

CLIM - Climate models In this video clip, a scientific expert tells us about climate models.

CLIM - Climate projections In this video clip, a scientific expert tells us about climate projections.

CLIM - Earth’s climate system In this video clip, a scientific expert tells us about the Earth’s climate system.

In this video clip, a scientific expert tells us more about the relations between the Food system and climate change.

In this video we learn with an expert about climate change and its impact on the forest. Jens Schroeder is a Professor of Forest Ecology.

In this video we learn with an expert about climate change and its impact on indigenous populations.